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SH2B1 SH2B1 GRB2 GRB2 SHC4 SHC4 SH2B2 SH2B2 PLCG1 PLCG1 ANGPT4 ANGPT4 PTPN14 PTPN14 LOC111183874 LOC111183874 PITPNM1 PITPNM1 CRK CRK PITPNM3 PITPNM3 LRP4 LRP4 CBLB CBLB LOC111186752 LOC111186752 GAB2 GAB2 SH2B3 SH2B3 PITPNM2 PITPNM2 PIK3R1 PIK3R1 ARHGEF16 ARHGEF16 GDNF GDNF GFRAL GFRAL DOCK4 DOCK4 NCK1 NCK1 GAS6 GAS6 HYAL2 HYAL2 ANGPT2 ANGPT2 RNF41 RNF41 SOCS5 SOCS5 MST1 MST1 FNTA FNTA DAZAP2 DAZAP2 FRS2 FRS2 GRB14 GRB14 SHC2 SHC2 ELMO2 ELMO2 ALKAL2 ALKAL2 ZPR1 ZPR1 DOK2 DOK2 NRTN NRTN PSPN PSPN SHC3 SHC3 ALKAL1 ALKAL1 TOB1 TOB1 CBL CBL MYOC MYOC SHC1 SHC1 RACK1 RACK1 PIK3R2 PIK3R2 PCNA PCNA CPNE3 CPNE3 PTPN2 PTPN2 MAP3K7 MAP3K7 CRKL CRKL PTPN11 PTPN11 PTPN1 PTPN1 NCK2 NCK2 FLT3LG FLT3LG FRS3 FRS3 ANGPT1 ANGPT1 CADM4 CADM4 TRADD TRADD FIZ1 FIZ1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SH2B1SH2B adapter protein 1 isoform X1. (795 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
SHC4SHC-transforming protein 4. (630 aa)
SH2B2SH2B adapter protein 2 isoform X1. (703 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
ANGPT4Angiopoietin-4. (498 aa)
PTPN14Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1187 aa)
LOC111183874Protein Tob1-like. (205 aa)
PITPNM1Membrane-associated phosphatidylinositol transfer protein 1. (1244 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
PITPNM3Membrane-associated phosphatidylinositol transfer protein 3 isoform X1. (1178 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1905 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (983 aa)
LOC111186752T-cell receptor-associated transmembrane adapter 1. (185 aa)
GAB2GRB2-associated-binding protein 2 isoform X1. (678 aa)
SH2B3SH2B adapter protein 3 isoform X1. (618 aa)
PITPNM2Membrane-associated phosphatidylinositol transfer protein 2. (1273 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16 isoform X1. (708 aa)
GDNFGlial cell line-derived neurotrophic factor. (185 aa)
GFRALLOW QUALITY PROTEIN: GDNF family receptor alpha-like. (397 aa)
DOCK4Dedicator of cytokinesis protein 4 isoform X1; Belongs to the DOCK family. (1971 aa)
NCK1Cytoplasmic protein. (377 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
HYAL2Hyaluronidase. (476 aa)
ANGPT2Angiopoietin-2 isoform X1. (496 aa)
RNF41E3 ubiquitin-protein ligase NRDP1 isoform X1. (317 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
MST1Hepatocyte growth factor-like protein isoform X1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
FNTAProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha isoform X1. (371 aa)
DAZAP2DAZ-associated protein 2 isoform X2. (207 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
GRB14Growth factor receptor-bound protein 14 isoform X1. (540 aa)
SHC2SHC-transforming protein 2 isoform X1. (588 aa)
ELMO2Engulfment and cell motility protein 2 isoform X1. (720 aa)
ALKAL2ALK and LTK ligand 2 isoform X1. (152 aa)
ZPR1Zinc finger protein ZPR1. (459 aa)
DOK2Docking protein 2. (411 aa)
NRTNNeurturin. (197 aa)
PSPNPersephin. (153 aa)
SHC3SHC-transforming protein 3. (588 aa)
ALKAL1ALK and LTK ligand 1. (121 aa)
TOB1Protein Tob1. (344 aa)
CBLE3 ubiquitin-protein ligase CBL isoform X1. (910 aa)
MYOCMyocilin. (476 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
RACK1Receptor of activated protein C kinase 1. (317 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CPNE3Copine-3. (533 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CRKLCrk-like protein. (303 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (451 aa)
NCK2Cytoplasmic protein. (376 aa)
FLT3LGFms-related tyrosine kinase 3 ligand isoform X1. (328 aa)
FRS3Fibroblast growth factor receptor substrate 3. (495 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
CADM4Cell adhesion molecule 4. (388 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa)
FIZ1Flt3-interacting zinc finger protein 1 isoform X1. (631 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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