STRINGSTRING
RAB5A RAB5A RAMP2 RAMP2 DNM2 DNM2 LRRTM1 LRRTM1 SNAP25 SNAP25 CLTC CLTC GRK3 GRK3 LDLRAP1 LDLRAP1 RAB31 RAB31 CNTN2 CNTN2 CACNG4 CACNG4 LMBRD1 LMBRD1 PICALM PICALM RAMP3 RAMP3 ARRB1 ARRB1 ARRB2 ARRB2 ITGB2 ITGB2 CACNG2 CACNG2 SCYL2 SCYL2 FCER1G FCER1G DNM3 DNM3 EZR EZR ARR3 ARR3 SYK SYK CALCRL CALCRL CAV3 CAV3 CALY CALY ACKR3 ACKR3 RAMP1 RAMP1 SAG SAG TFRC TFRC HTR2B HTR2B DRD3 DRD3 SNX1 SNX1 DNM1 DNM1 NEDD4 NEDD4 ITGB1 ITGB1 CAV1 CAV1 CACNG8 CACNG8 ACHE ACHE CACNG7 CACNG7 HGS HGS CACNG5 CACNG5 CD81 CD81 GRK2 GRK2 GRB2 GRB2 GRIA1 GRIA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
RAMP2Receptor activity-modifying protein 2. (177 aa)
DNM2Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
LRRTM1Leucine-rich repeat transmembrane neuronal protein 1. (522 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
GRK3G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
LDLRAP1LOW QUALITY PROTEIN: low density lipoprotein receptor adapter protein 1. (309 aa)
RAB31Ras-related protein Rab-31 isoform X1. (194 aa)
CNTN2Contactin-2. (1043 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (375 aa)
LMBRD1Probable lysosomal cobalamin transporter. (539 aa)
PICALMPhosphatidylinositol-binding clathrin assembly protein isoform X1. (696 aa)
RAMP3Receptor activity-modifying protein 3. (151 aa)
ARRB1Beta-arrestin-1 isoform X1. (430 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
ITGB2Integrin beta. (769 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
SCYL2SCY1-like protein 2 isoform X1. (929 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
DNM3Dynamin-3 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (873 aa)
EZREzrin. (586 aa)
ARR3arrestin-C. (339 aa)
SYKTyrosine-protein kinase. (626 aa)
CALCRLCalcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family. (462 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
CALYNeuron-specific vesicular protein calcyon isoform X1. (269 aa)
ACKR3Atypical chemokine receptor 3 isoform X1; Belongs to the G-protein coupled receptor 1 family. (417 aa)
RAMP1Receptor activity-modifying protein 1. (148 aa)
SAGS-arrestin. (408 aa)
TFRCTransferrin receptor protein 1 isoform X1. (772 aa)
HTR2B5-hydroxytryptamine receptor 2B. (490 aa)
DRD3D(3) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
SNX1Sorting nexin-1 isoform X1. (522 aa)
DNM1Dynamin-1 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (868 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform X3. (1319 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (496 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (617 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit isoform X1. (275 aa)
CD81Tetraspanin. (236 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
GRIA1Glutamate receptor 1 isoform X1. (906 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: medium (58%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.