STRINGSTRING
IL12B IL12B F2RL1 F2RL1 FAM49B FAM49B NOD2 NOD2 ISL1 ISL1 LOC111165935 LOC111165935 TYK2 TYK2 RARA RARA CCR7 CCR7 SLAMF6 SLAMF6 IL27RA IL27RA IL12RB1 IL12RB1 LOC111167004 LOC111167004 IL18 IL18 TLR7 TLR7 TLR8 TLR8 CRTAM CRTAM SASH3 SASH3 LOC111168424 LOC111168424 SLAMF1 SLAMF1 PGLYRP2 PGLYRP2 FOXP3 FOXP3 HRAS HRAS IL1B IL1B TNF TNF IL1RL1 IL1RL1 ARID5A ARID5A IL1R1 IL1R1 IL36RN IL36RN NR1H4 NR1H4 LGALS9 LGALS9 IL18R1 IL18R1 PDE4D PDE4D C1QBP C1QBP IL10 IL10 TICAM2 TICAM2 VSIR VSIR CD14 CD14 FADD FADD IL27 IL27 ZP3 ZP3 RASGRP1 RASGRP1 CD226 CD226 PYCARD PYCARD CD2 CD2 SLC7A5 SLC7A5 BCL3 BCL3 PDE4B PDE4B CEBPG CEBPG AXL AXL GATA3 GATA3 IL12RB2 IL12RB2 IL20RB IL20RB IRF8 IRF8 ABL1 ABL1 LOC111176900 LOC111176900 ZFPM1 ZFPM1 LRRC1 LRRC1 LOC111178657 LOC111178657 GAS6 GAS6 IL12A IL12A LOC111176754 LOC111176754 ZC3H12A ZC3H12A CD96 CD96 TLR9 TLR9 WNT5A WNT5A DDIT3 DDIT3 TLR3 TLR3 HSPD1 HSPD1 TNFSF4 TNFSF4 TXK TXK SLC11A1 SLC11A1 FZD5 FZD5 LTA LTA NLRP6 NLRP6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
FAM49BProtein FAM49B isoform X1. (324 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
RARARetinoic acid receptor alpha isoform X5. (584 aa)
CCR7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
SLAMF6SLAM family member 6 isoform X1. (335 aa)
IL27RAInterleukin-27 receptor subunit alpha isoform X1. (656 aa)
IL12RB1Interleukin-12 receptor subunit beta-1 isoform X1. (726 aa)
LOC111167004LOW QUALITY PROTEIN: peptidoglycan recognition protein 3-like. (277 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
TLR7Toll-like receptor 7 isoform X1. (1086 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1035 aa)
CRTAMCytotoxic and regulatory T-cell molecule isoform X1. (391 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
LOC111168424Zinc finger protein RFP. (513 aa)
SLAMF1Signaling lymphocytic activation molecule isoform X1. (378 aa)
PGLYRP2N-acetylmuramoyl-L-alanine amidase isoform X1. (581 aa)
FOXP3Forkhead box protein P3. (431 aa)
HRASGTPase HRas isoform X1. (189 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1RL1Interleukin-1 receptor-like 1 isoform X1. (592 aa)
ARID5AAT-rich interactive domain-containing protein 5A isoform X1. (593 aa)
IL1R1Interleukin-1 receptor type 1 isoform X1. (686 aa)
IL36RNInterleukin-1. (155 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
LGALS9Galectin. (356 aa)
IL18R1Interleukin-18 receptor 1 isoform X1. (539 aa)
PDE4DPhosphodiesterase. (805 aa)
C1QBPComplement component 1 Q subcomponent-binding protein, mitochondrial. (278 aa)
IL10Interleukin-10. (178 aa)
TICAM2TIR domain-containing adapter molecule 2. (235 aa)
VSIRV-type immunoglobulin domain-containing suppressor of T-cell activation. (311 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
IL27Interleukin-27 subunit alpha. (237 aa)
ZP3Zona pellucida sperm-binding protein 3. (421 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (870 aa)
CD226CD226 antigen. (335 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
CD2T-cell surface antigen CD2 isoform X1. (340 aa)
SLC7A5Large neutral amino acids transporter small subunit 1 isoform X1. (505 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
PDE4BPhosphodiesterase. (736 aa)
CEBPGCCAAT/enhancer-binding protein gamma. (149 aa)
AXLLOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO. (887 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
IL12RB2Interleukin-12 receptor subunit beta-2 isoform X1. (861 aa)
IL20RBInterleukin-20 receptor subunit beta isoform X1. (342 aa)
IRF8Interferon regulatory factor 8 isoform X1. (427 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
LOC111176900GTPase IMAP family member 5-like isoform X1. (332 aa)
ZFPM1Zinc finger protein ZFPM1 isoform X1. (1069 aa)
LRRC1Leucine-rich repeat-containing protein 1. (395 aa)
LOC111178657Leucine-rich repeat-containing protein 1-like isoform X1. (174 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
LOC111176754C-type lectin domain family 7 member A-like isoform X1. (244 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
CD96LOW QUALITY PROTEIN: T-cell surface protein tactile. (546 aa)
TLR9LOW QUALITY PROTEIN: toll-like receptor 9. (1323 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
HSPD160 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (573 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (182 aa)
TXKTyrosine-protein kinase. (550 aa)
SLC11A1Natural resistance-associated macrophage protein 1 isoform X1. (546 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
LTALymphotoxin-alpha; Belongs to the tumor necrosis factor family. (205 aa)
NLRP6LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6. (876 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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