STRINGSTRING
RAB7B RAB7B IL1B IL1B TNF TNF Ob Ob TRPV4 TRPV4 TLR2 TLR2 IL1RL2 IL1RL2 ARID5A ARID5A PTPN11 PTPN11 C1QTNF3 C1QTNF3 EREG EREG IL36RN IL36RN NR1H4 NR1H4 CEBPB CEBPB NLRC3 NLRC3 F2R F2R LOC111185989 LOC111185989 ARRB2 ARRB2 ARRB1 ARRB1 MAVS MAVS LBP LBP MAPKAPK2 MAPKAPK2 GHSR GHSR IL10 IL10 TICAM2 TICAM2 DHX9 DHX9 BPI BPI TWIST1 TWIST1 C1QTNF4 C1QTNF4 CD74 CD74 TMEM130 TMEM130 LEP LEP FOXJ1 FOXJ1 SPHK2 SPHK2 PTPN22 PTPN22 PYCARD PYCARD TRAF6 TRAF6 POU2F2 POU2F2 C5AR2 C5AR2 NOD1 NOD1 TREM2 TREM2 BANK1 BANK1 PLCG2 PLCG2 IL17F IL17F LOC111179403 LOC111179403 MAPK13 MAPK13 IL17RA IL17RA CARD9 CARD9 IL17A IL17A GAS6 GAS6 PTPN6 PTPN6 APP APP HYAL2 HYAL2 LOC111176754 LOC111176754 IFNG IFNG ZC3H12A ZC3H12A F2RL1 F2RL1 AKIRIN2 AKIRIN2 SETD4 SETD4 MYD88 MYD88 HGF HGF NOD2 NOD2 ISL1 ISL1 ZBTB20 ZBTB20 TNFAIP3 TNFAIP3 SYT11 SYT11 IL27RA IL27RA CD84 CD84 GBA GBA MBP MBP TLR7 TLR7 TLR8 TLR8 NLRX1 NLRX1 ARHGEF2 ARHGEF2 CUNHXorf40A CUNHXorf40A ADORA2B ADORA2B LOC111165753 LOC111165753 MMP8 MMP8 POU2AF1 POU2AF1 CUNH1orf106 CUNH1orf106 SLAMF1 SLAMF1 LPL LPL NMBR NMBR FOXP3 FOXP3 TMEM106A TMEM106A SYK SYK IL17RC IL17RC AIF1 AIF1 AGER AGER LOC111171320 LOC111171320 TNFSF4 TNFSF4 IFIH1 IFIH1 HSPD1 HSPD1 INPP5D INPP5D AFAP1L2 AFAP1L2 NCKAP1L NCKAP1L TLR3 TLR3 SOCS5 SOCS5 IL17D IL17D WNT5A WNT5A TLR9 TLR9 UCN UCN IRAK3 IRAK3 IL1RAP IL1RAP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB7BRas-related protein Rab-7b isoform X1. (210 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ObLeptin isoform X1. (167 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
IL1RL2Interleukin-1 receptor-like 2 isoform X1. (570 aa)
ARID5AAT-rich interactive domain-containing protein 5A isoform X1. (593 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
C1QTNF3Complement C1q tumor necrosis factor-related protein 3 isoform X1. (319 aa)
EREGProepiregulin. (163 aa)
IL36RNInterleukin-1. (155 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
NLRC3NLR family CARD domain-containing protein 3 isoform X1. (1066 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
ARRB1Beta-arrestin-1 isoform X1. (430 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (581 aa)
LBPLipopolysaccharide-binding protein isoform X1. (537 aa)
MAPKAPK2LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (414 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
IL10Interleukin-10. (178 aa)
TICAM2TIR domain-containing adapter molecule 2. (235 aa)
DHX9ATP-dependent RNA helicase A isoform X1. (1253 aa)
BPIBactericidal permeability-increasing protein isoform X1. (483 aa)
TWIST1Twist-related protein 1. (205 aa)
C1QTNF4Complement C1q tumor necrosis factor-related protein 4 isoform X1. (329 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
TMEM130Transmembrane protein 130 isoform X1. (435 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
FOXJ1Forkhead box protein J1. (422 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
POU2F2POU domain protein. (614 aa)
C5AR2C5a anaphylatoxin chemotactic receptor 2 isoform X1. (343 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
BANK1B-cell scaffold protein with ankyrin repeats isoform X1. (785 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
IL17Finterleukin-17F. (165 aa)
LOC111179403Cytochrome b-245 light chain isoform X1. (202 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
IL17RAInterleukin-17 receptor A isoform X1. (847 aa)
CARD9Caspase recruitment domain-containing protein 9 isoform X1. (539 aa)
IL17Ainterleukin-17A. (155 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
APPAmyloid beta A4 protein isoform X1. (767 aa)
HYAL2Hyaluronidase. (476 aa)
LOC111176754C-type lectin domain family 7 member A-like isoform X1. (244 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
AKIRIN2Akirin-2. (203 aa)
SETD4SET domain-containing protein 4. (440 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20 isoform X1. (741 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
SYT11Synaptotagmin-11 isoform X1. (428 aa)
IL27RAInterleukin-27 receptor subunit alpha isoform X1. (656 aa)
CD84SLAM family member 5 isoform X1. (341 aa)
GBAGlucosylceramidase. (585 aa)
MBPMyelin basic protein isoform X1. (326 aa)
TLR7Toll-like receptor 7 isoform X1. (1086 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1035 aa)
NLRX1NLR family member X1 isoform X1. (973 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (1032 aa)
CUNHXorf40AProtein CXorf40A homolog isoform X1. (158 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
LOC111165753NACHT, LRR and PYD domains-containing protein 12 isoform X2. (1105 aa)
MMP8Neutrophil collagenase isoform X1. (468 aa)
POU2AF1POU domain class 2-associating factor 1. (256 aa)
CUNH1orf106Uncharacterized protein C1orf106 homolog. (540 aa)
SLAMF1Signaling lymphocytic activation molecule isoform X1. (378 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (478 aa)
NMBRLOW QUALITY PROTEIN: neuromedin-B receptor. (394 aa)
FOXP3Forkhead box protein P3. (431 aa)
TMEM106ATransmembrane protein 106A isoform X1. (293 aa)
SYKTyrosine-protein kinase. (626 aa)
IL17RCInterleukin-17 receptor C isoform X1. (713 aa)
AIF1Allograft inflammatory factor 1 isoform X1. (162 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
LOC111171320Mucin-16-like. (855 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (182 aa)
IFIH1Interferon-induced helicase C domain-containing protein 1. (1023 aa)
HSPD160 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (573 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
AFAP1L2Actin filament-associated protein 1-like 2 isoform X1. (938 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1156 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
IL17Dinterleukin-17D. (309 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
TLR9LOW QUALITY PROTEIN: toll-like receptor 9. (1323 aa)
UCNUrocortin. (126 aa)
IRAK3Interleukin-1 receptor-associated kinase 3 isoform X2. (674 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform X2. (685 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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