STRINGSTRING
IL1B IL1B MYD88 MYD88 NOD2 NOD2 STAT3 STAT3 APOA2 APOA2 TLR7 TLR7 TLR8 TLR8 ANXA4 ANXA4 PTPRC PTPRC CACTIN CACTIN GDF2 GDF2 SYK SYK ELANE ELANE OTUD7B OTUD7B AFAP1L2 AFAP1L2 TLR3 TLR3 DDIT3 DDIT3 ANXA1 ANXA1 IL17D IL17D WNT5A WNT5A LOC111176754 LOC111176754 HYAL2 HYAL2 IL17F IL17F LOC111177076 LOC111177076 CD58 CD58 PRKD2 PRKD2 BCL10 BCL10 NOD1 NOD1 C5AR2 C5AR2 BCL3 BCL3 CD2 CD2 PYCARD PYCARD RIPK1 RIPK1 PTPN22 PTPN22 ZNF580 ZNF580 LEP LEP MAPKBP1 MAPKBP1 CD74 CD74 FADD FADD CD14 CD14 RELA RELA BPI BPI F3 F3 LBP LBP MAVS MAVS CHI3L1 CHI3L1 RAB1A RAB1A F2RL1 F2RL1 ARRB1 ARRB1 LOC111185989 LOC111185989 F2R F2R PARK7 PARK7 TLR2 TLR2 Ob Ob TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
APOA2Apolipoprotein A-II. (103 aa)
TLR7Toll-like receptor 7 isoform X1. (1086 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1035 aa)
ANXA4Annexin. (319 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
CACTINCactin. (755 aa)
GDF2Growth/differentiation factor 2. (431 aa)
SYKTyrosine-protein kinase. (626 aa)
ELANENeutrophil elastase; Belongs to the peptidase S1 family. (308 aa)
OTUD7BOTU domain-containing protein 7B isoform X1. (874 aa)
AFAP1L2Actin filament-associated protein 1-like 2 isoform X1. (938 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
ANXA1Annexin. (346 aa)
IL17Dinterleukin-17D. (309 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
LOC111176754C-type lectin domain family 7 member A-like isoform X1. (244 aa)
HYAL2Hyaluronidase. (476 aa)
IL17Finterleukin-17F. (165 aa)
LOC111177076Ficolin-2-like isoform X1. (326 aa)
CD58Lymphocyte function-associated antigen 3 isoform X1. (242 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
C5AR2C5a anaphylatoxin chemotactic receptor 2 isoform X1. (343 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
CD2T-cell surface antigen CD2 isoform X1. (340 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
ZNF580Zinc finger protein 580 isoform X1. (182 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
MAPKBP1Mitogen-activated protein kinase-binding protein 1 isoform X1. (1510 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
RELATranscription factor p65 isoform X1. (562 aa)
BPIBactericidal permeability-increasing protein isoform X1. (483 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
LBPLipopolysaccharide-binding protein isoform X1. (537 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (581 aa)
CHI3L1LOW QUALITY PROTEIN: chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (393 aa)
RAB1ARas-related protein Rab-1A. (205 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
ARRB1Beta-arrestin-1 isoform X1. (430 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PARK7Protein DJ-1. (189 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
ObLeptin isoform X1. (167 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.