STRINGSTRING
TMEM106A TMEM106A SYK SYK AZU1 AZU1 IL12B IL12B NFKBIL1 NFKBIL1 AGER AGER FZD5 FZD5 IFIH1 IFIH1 TLR3 TLR3 TREX1 TREX1 ARG2 ARG2 TWIST1 TWIST1 CD14 CD14 FADD FADD C1QTNF4 C1QTNF4 THBS1 THBS1 FRMD8 FRMD8 LEP LEP HSPB1 HSPB1 SPHK2 SPHK2 RASGRP1 RASGRP1 PTPN22 PTPN22 RIPK1 RIPK1 PYCARD PYCARD CD2 CD2 BCL3 BCL3 C5AR2 C5AR2 NOD1 NOD1 ZFP36 ZFP36 TREM2 TREM2 AXL AXL PLCG2 PLCG2 LOC111179403 LOC111179403 PSEN1 PSEN1 CARD9 CARD9 IL17A IL17A GPR18 GPR18 GAS6 GAS6 CHRNA7 CHRNA7 PTPN6 PTPN6 APP APP FOXP1 FOXP1 DICER1 DICER1 LOC111176754 LOC111176754 LTF LTF ZC3H12A ZC3H12A GHSR GHSR IRAK3 IRAK3 TLR9 TLR9 WNT5A WNT5A Ob Ob BPI BPI VSIR VSIR DHX9 DHX9 MAPKAPK2 MAPKAPK2 LBP LBP MAVS MAVS LY96 LY96 ARRB2 ARRB2 NLRC3 NLRC3 LOC111186676 LOC111186676 PIK3R1 PIK3R1 NR1H4 NR1H4 TNFRSF8 TNFRSF8 ARFGEF2 ARFGEF2 IGF1 IGF1 PTPN11 PTPN11 CCL19 CCL19 LOC111163731 LOC111163731 EPHB2 EPHB2 UBE2J1 UBE2J1 SETD4 SETD4 CIDEA CIDEA MYD88 MYD88 NOD2 NOD2 ISL1 ISL1 TIRAP TIRAP NFATC4 NFATC4 ZBTB20 ZBTB20 ARID5A ARID5A RARA RARA STAT3 STAT3 TNFAIP3 TNFAIP3 SYT11 SYT11 IL27RA IL27RA CD84 CD84 ARHGEF2 ARHGEF2 MMP8 MMP8 SASH3 SASH3 PTPRC PTPRC CACTIN CACTIN LOC111168424 LOC111168424 SLAMF1 SLAMF1 LPL LPL CX3CR1 CX3CR1 FOXP3 FOXP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMEM106ATransmembrane protein 106A isoform X1. (293 aa)
SYKTyrosine-protein kinase. (626 aa)
AZU1Azurocidin. (252 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
NFKBIL1NF-kappa-B inhibitor-like protein 1 isoform X1. (380 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
IFIH1Interferon-induced helicase C domain-containing protein 1. (1023 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
TREX1Three-prime repair exonuclease 1. (314 aa)
ARG2Arginase. (354 aa)
TWIST1Twist-related protein 1. (205 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
C1QTNF4Complement C1q tumor necrosis factor-related protein 4 isoform X1. (329 aa)
THBS1Thrombospondin-1. (1170 aa)
FRMD8FERM domain-containing protein 8 isoform X1. (465 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (870 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
CD2T-cell surface antigen CD2 isoform X1. (340 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
C5AR2C5a anaphylatoxin chemotactic receptor 2 isoform X1. (343 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
ZFP36mRNA decay activator protein ZFP36. (325 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
AXLLOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO. (887 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
LOC111179403Cytochrome b-245 light chain isoform X1. (202 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
CARD9Caspase recruitment domain-containing protein 9 isoform X1. (539 aa)
IL17Ainterleukin-17A. (155 aa)
GPR18N-arachidonyl glycine receptor; Belongs to the G-protein coupled receptor 1 family. (338 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7 isoform X2. (499 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
APPAmyloid beta A4 protein isoform X1. (767 aa)
FOXP1Forkhead box protein P1 isoform X1. (673 aa)
DICER1Endoribonuclease Dicer; Belongs to the helicase family. Dicer subfamily. (1921 aa)
LOC111176754C-type lectin domain family 7 member A-like isoform X1. (244 aa)
LTFLactotransferrin; Belongs to the transferrin family. (710 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
IRAK3Interleukin-1 receptor-associated kinase 3 isoform X2. (674 aa)
TLR9LOW QUALITY PROTEIN: toll-like receptor 9. (1323 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
ObLeptin isoform X1. (167 aa)
BPIBactericidal permeability-increasing protein isoform X1. (483 aa)
VSIRV-type immunoglobulin domain-containing suppressor of T-cell activation. (311 aa)
DHX9ATP-dependent RNA helicase A isoform X1. (1253 aa)
MAPKAPK2LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (414 aa)
LBPLipopolysaccharide-binding protein isoform X1. (537 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (581 aa)
LY96Lymphocyte antigen 96. (160 aa)
ARRB2Beta-arrestin-2 isoform X1. (409 aa)
NLRC3NLR family CARD domain-containing protein 3 isoform X1. (1066 aa)
LOC111186676Uncharacterized protein C6orf106. (290 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
TNFRSF8Tumor necrosis factor receptor superfamily member 8. (598 aa)
ARFGEF2Brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1. (1785 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
CCL19C-C motif chemokine. (159 aa)
LOC111163731C-C motif chemokine. (93 aa)
EPHB2Ephrin type-B receptor 2 isoform X1. (987 aa)
UBE2J1Ubiquitin-conjugating enzyme E2 J1. (318 aa)
SETD4SET domain-containing protein 4. (440 aa)
CIDEACell death activator CIDE-A. (219 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (226 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20 isoform X1. (741 aa)
ARID5AAT-rich interactive domain-containing protein 5A isoform X1. (593 aa)
RARARetinoic acid receptor alpha isoform X5. (584 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
SYT11Synaptotagmin-11 isoform X1. (428 aa)
IL27RAInterleukin-27 receptor subunit alpha isoform X1. (656 aa)
CD84SLAM family member 5 isoform X1. (341 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (1032 aa)
MMP8Neutrophil collagenase isoform X1. (468 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
CACTINCactin. (755 aa)
LOC111168424Zinc finger protein RFP. (513 aa)
SLAMF1Signaling lymphocytic activation molecule isoform X1. (378 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (478 aa)
CX3CR1CX3C chemokine receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
FOXP3Forkhead box protein P3. (431 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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