35 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ARRB1	Beta-arrestin-1 isoform X1. (430 aa)
	ARRB2	Beta-arrestin-2 isoform X1. (409 aa)
	IL10	Interleukin-10. (178 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (785 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
	SYT11	Synaptotagmin-11 isoform X1. (428 aa)
	IL27RA	Interleukin-27 receptor subunit alpha isoform X1. (656 aa)
	NLRC3	NLR family CARD domain-containing protein 3 isoform X1. (1066 aa)
	GBA	Glucosylceramidase. (585 aa)
	NR1H4	Bile acid receptor isoform X1. (486 aa)
	IL36RN	Interleukin-1. (155 aa)
	C1QTNF3	Complement C1q tumor necrosis factor-related protein 3 isoform X1. (319 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
	CD84	SLAM family member 5 isoform X1. (341 aa)
	NLRX1	NLR family member X1 isoform X1. (973 aa)
	LOC111165753	NACHT, LRR and PYD domains-containing protein 12 isoform X2. (1105 aa)
	SLAMF1	Signaling lymphocytic activation molecule isoform X1. (378 aa)
	NMBR	LOW QUALITY PROTEIN: neuromedin-B receptor. (394 aa)
	FOXP3	Forkhead box protein P3. (431 aa)
	LOC111171320	Mucin-16-like. (855 aa)
	INPP5D	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
	NCKAP1L	Nck-associated protein 1-like isoform X1. (1156 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	TLR9	LOW QUALITY PROTEIN: toll-like receptor 9. (1323 aa)
	IRAK3	Interleukin-1 receptor-associated kinase 3 isoform X2. (674 aa)
	GHSR	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	ZC3H12A	Endoribonuclease ZC3H12A. (583 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	GAS6	Growth arrest-specific protein 6. (671 aa)
	BANK1	B-cell scaffold protein with ankyrin repeats isoform X1. (785 aa)
	C5AR2	C5a anaphylatoxin chemotactic receptor 2 isoform X1. (343 aa)
	PTPN22	Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
	FOXJ1	Forkhead box protein J1. (422 aa)
	TMEM130	Transmembrane protein 130 isoform X1. (435 aa)
	BPI	Bactericidal permeability-increasing protein isoform X1. (483 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB1	ARRB2	A0A2Y9Q1W6	A0A2Y9Q297	Beta-arrestin-1 isoform X1.	Beta-arrestin-2 isoform X1.	0.935
ARRB2	ARRB1	A0A2Y9Q297	A0A2Y9Q1W6	Beta-arrestin-2 isoform X1.	Beta-arrestin-1 isoform X1.	0.935
ARRB2	C5AR2	A0A2Y9Q297	A0A2Y9P499	Beta-arrestin-2 isoform X1.	C5a anaphylatoxin chemotactic receptor 2 isoform X1.	0.417
ARRB2	NMBR	A0A2Y9Q297	A0A2Y9MC48	Beta-arrestin-2 isoform X1.	LOW QUALITY PROTEIN: neuromedin-B receptor.	0.591
BANK1	PTPN22	A0A2Y9NYV9	A0A2Y9PBC1	B-cell scaffold protein with ankyrin repeats isoform X1.	Tyrosine-protein phosphatase non-receptor type 22 isoform X1.	0.452
C5AR2	ARRB2	A0A2Y9P499	A0A2Y9Q297	C5a anaphylatoxin chemotactic receptor 2 isoform X1.	Beta-arrestin-2 isoform X1.	0.417
FOXP3	IL10	A0A2Y9MEL9	A0A2Y9PUU1	Forkhead box protein P3.	Interleukin-10.	0.810
FOXP3	TLR9	A0A2Y9MEL9	A0A2Y9N6G5	Forkhead box protein P3.	LOW QUALITY PROTEIN: toll-like receptor 9.	0.438
FOXP3	TNF	A0A2Y9MEL9	Q8WNR1	Forkhead box protein P3.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.680
GBA	INPP5D	A0A2Y9LZW6	A0A2Y9MYB1	Glucosylceramidase.	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1.	0.836
HGF	IL10	A0A2Y9LK73	A0A2Y9PUU1	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Interleukin-10.	0.628
HGF	TNF	A0A2Y9LK73	Q8WNR1	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.507
IL10	FOXP3	A0A2Y9PUU1	A0A2Y9MEL9	Interleukin-10.	Forkhead box protein P3.	0.810
IL10	HGF	A0A2Y9PUU1	A0A2Y9LK73	Interleukin-10.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.628
IL10	IL27RA	A0A2Y9PUU1	A0A2Y9LZI4	Interleukin-10.	Interleukin-27 receptor subunit alpha isoform X1.	0.714
IL10	IL36RN	A0A2Y9PUU1	A0A2Y9QBN1	Interleukin-10.	Interleukin-1.	0.516
IL10	TLR9	A0A2Y9PUU1	A0A2Y9N6G5	Interleukin-10.	LOW QUALITY PROTEIN: toll-like receptor 9.	0.622
IL10	TNF	A0A2Y9PUU1	Q8WNR1	Interleukin-10.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.901
IL27RA	IL10	A0A2Y9LZI4	A0A2Y9PUU1	Interleukin-27 receptor subunit alpha isoform X1.	Interleukin-10.	0.714
IL36RN	IL10	A0A2Y9QBN1	A0A2Y9PUU1	Interleukin-1.	Interleukin-10.	0.516