STRINGSTRING
OPRD1 OPRD1 OSM OSM PRKD1 PRKD1 RET RET IFNE IFNE LOC111163130 LOC111163130 CSF3 CSF3 NTRK2 NTRK2 LATS1 LATS1 HAX1 HAX1 SH2D3A SH2D3A NTRK3 NTRK3 LOC111169218 LOC111169218 HDAC6 HDAC6 WNT3A WNT3A HCLS1 HCLS1 CAMK1 CAMK1 RAF1 RAF1 CNOT9 CNOT9 LOC111171121 LOC111171121 GCG GCG MTCP1 MTCP1 LOC111171122 LOC111171122 PIK3CA PIK3CA RAPGEF3 RAPGEF3 IFNB1 IFNB1 WNT5A WNT5A UCN UCN EIF4G1 EIF4G1 TCL1A TCL1A IFNG IFNG NTF3 NTF3 TCL1B TCL1B CREBL2 CREBL2 PDCD10 PDCD10 APP APP MAPKAP1 MAPKAP1 GAS6 GAS6 SPRY2 SPRY2 SH2D3C SH2D3C BRAF BRAF DOCK7 DOCK7 FNIP2 FNIP2 SMYD3 SMYD3 TERF2IP TERF2IP CAV1 CAV1 PRKD2 PRKD2 PFN2 PFN2 TGFB1 TGFB1 GSK3A GSK3A CD44 CD44 IL11 IL11 BCL2 BCL2 NGF NGF FNIP1 FNIP1 NTF4 NTF4 AKAP9 AKAP9 RPTOR RPTOR STOX1 STOX1 TNKS1BP1 TNKS1BP1 AVP AVP ATP2B4 ATP2B4 PAK1 PAK1 STK4 STK4 AXIN1 AXIN1 RAMP3 RAMP3 EGFR EGFR PTGS2 PTGS2 MAD2L2 MAD2L2 NOS1 NOS1 PARK7 PARK7 SFRP2 SFRP2 TNF TNF LOC111163131 LOC111163131 LIF LIF PINK1 PINK1 BCAR3 BCAR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OPRD1Delta-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (368 aa)
OSMoncostatin-M. (246 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
IFNEInterferon epsilon. (193 aa)
LOC111163130Interferon alpha-1-like. (226 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
LATS1Serine/threonine-protein kinase LATS1. (1128 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (276 aa)
SH2D3ASH2 domain-containing protein 3A isoform X1. (601 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
LOC111169218Tripartite motif-containing protein 6-like. (487 aa)
HDAC6Histone deacetylase 6 isoform X1. (1149 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
HCLS1Hematopoietic lineage cell-specific protein. (481 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1; Belongs to the protein kinase superfamily. (370 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (299 aa)
LOC111171121Interferon alpha-1-like. (133 aa)
GCGGlucagon isoform X1. (180 aa)
MTCP1Protein p13 MTCP-1. (107 aa)
LOC111171122Interferon alpha-1-like isoform X1. (195 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X2. (958 aa)
IFNB1Interferon beta. (185 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
UCNUrocortin. (126 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1 isoform X1. (1608 aa)
TCL1AT-cell leukemia/lymphoma protein 1A. (115 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (265 aa)
TCL1BT-cell leukemia/lymphoma protein 1B. (168 aa)
CREBL2cAMP-responsive element-binding protein-like 2 isoform X1. (147 aa)
PDCD10Programmed cell death protein 10. (212 aa)
APPAmyloid beta A4 protein isoform X1. (767 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform X1. (522 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
SH2D3CSH2 domain-containing protein 3C isoform X1. (861 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
DOCK7Dedicator of cytokinesis protein 7 isoform X1; Belongs to the DOCK family. (2131 aa)
FNIP2Folliculin-interacting protein 2 isoform X1. (1083 aa)
SMYD3Histone-lysine N-methyltransferase SMYD3. (428 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1. (398 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
PFN2Profilin; Belongs to the profilin family. (197 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
CD44CD44 antigen isoform X1. (742 aa)
IL11Interleukin-11. (199 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
FNIP1Folliculin-interacting protein 1 isoform X1. (1165 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (247 aa)
AKAP9A-kinase anchor protein 9 isoform X1. (3902 aa)
RPTORRegulatory-associated protein of mTOR isoform X7. (1335 aa)
STOX1Storkhead-box protein 1 isoform X1. (990 aa)
TNKS1BP1182 kDa tankyrase-1-binding protein isoform X1. (1717 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (166 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
STK4Serine/threonine-protein kinase 4 isoform X1. (487 aa)
AXIN1Axin-1 isoform X1. (866 aa)
RAMP3Receptor activity-modifying protein 3. (151 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
NOS1Nitric oxide synthase, brain isoform X1. (1461 aa)
PARK7Protein DJ-1. (189 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
LOC111163131Interferon alpha-13-like. (170 aa)
LIFLeukemia inhibitory factor. (202 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial isoform X1. (584 aa)
BCAR3Breast cancer anti-estrogen resistance protein 3 isoform X1. (832 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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