STRINGSTRING
HRAS HRAS HCLS1 HCLS1 GRIPAP1 GRIPAP1 CTDSPL2 CTDSPL2 PTPN22 PTPN22 GSK3B GSK3B OAZ3 OAZ3 ARHGAP44 ARHGAP44 ZPR1 ZPR1 MIEF2 MIEF2 CUNH11orf65 CUNH11orf65 LOC111165935 LOC111165935 SEC16B SEC16B EPM2A EPM2A SORL1 SORL1 ERBB2 ERBB2 SIRT6 SIRT6 SLC35D3 SLC35D3 FBXW9 FBXW9 PRKACA PRKACA PIK3R2 PIK3R2 FIS1 FIS1 SIRT7 SIRT7 BBC3 BBC3 TOMM7 TOMM7 SAR1B SAR1B SH3TC2 SH3TC2 CHP2 CHP2 SEPT8 SEPT8 LEP LEP SAR1A SAR1A CD81 CD81 TMEM30A TMEM30A PTPN14 PTPN14 PKIG PKIG HDAC3 HDAC3 RBM22 RBM22 ERGIC3 ERGIC3 EDEM2 EDEM2 YOD1 YOD1 TPR TPR RAB29 RAB29 B3GAT3 B3GAT3 DERL2 DERL2 INPP5K INPP5K TM9SF4 TM9SF4 MAVS MAVS GLI3 GLI3 LOC111186315 LOC111186315 CDK5R1 CDK5R1 NDEL1 NDEL1 UBE2G2 UBE2G2 MIEF1 MIEF1 CABP1 CABP1 PINK1 PINK1 SFN SFN UBE2J1 UBE2J1 PRKD1 PRKD1 TARDBP TARDBP ERLEC1 ERLEC1 KCNB1 KCNB1 NF1 NF1 MYO1C MYO1C YWHAE YWHAE PIK3R1 PIK3R1 DERL3 DERL3 ITGB1BP1 ITGB1BP1 FYN FYN SH3TC1 SH3TC1 ZFAND1 ZFAND1 PRR5L PRR5L RIPOR1 RIPOR1 ICE1 ICE1 UBR5 UBR5 PDZK1 PDZK1 SVIP SVIP LOC111177759 LOC111177759 INSIG1 INSIG1 PSEN1 PSEN1 OAZ2 OAZ2 MDFI MDFI C2CD5 C2CD5 RAB23 RAB23 TGFB1 TGFB1 CDK5 CDK5 SMO SMO SLC51B SLC51B DMAP1 DMAP1 EFCAB7 EFCAB7 LOC111177285 LOC111177285 LCP1 LCP1 GAS6 GAS6 IPO5 IPO5 TCAF1 TCAF1 HYAL2 HYAL2 PDCD10 PDCD10 PRKAA1 PRKAA1 ANP32B ANP32B GCC2 GCC2 XPO1 XPO1 FBXW7 FBXW7 PTPN1 PTPN1 PTPN11 PTPN11 PARK7 PARK7 Ob Ob SHH SHH IFNG IFNG PARL PARL PRKCD PRKCD EDEM1 EDEM1 ZC3H12A ZC3H12A SIAH3 SIAH3 XPO4 XPO4 OS9 OS9 FERMT1 FERMT1 LOC111174204 LOC111174204 LRRK2 LRRK2 GRASP GRASP DNAJC27 DNAJC27 UBAC2 UBAC2 FRAT1 FRAT1 RAPGEF3 RAPGEF3 PLK3 PLK3 OAZ1 OAZ1 TCF7L2 TCF7L2 ECT2 ECT2 PCM1 PCM1 MFF MFF JUP JUP CEMIP CEMIP PPM1A PPM1A TMEM30B TMEM30B AKAP5 AKAP5 BMP4 BMP4 BAG3 BAG3 APOD APOD UHMK1 UHMK1 TRIM28 TRIM28 DMTN DMTN CAMK1 CAMK1 CIB1 CIB1 GDI1 GDI1 LOC111170664 LOC111170664 EMD EMD FLNA FLNA BCAP31 BCAP31 GSK3A GSK3A PDCD5 PDCD5 CDH1 CDH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HRASGTPase HRas isoform X1. (189 aa)
HCLS1Hematopoietic lineage cell-specific protein. (481 aa)
GRIPAP1GRIP1-associated protein 1 isoform X1. (842 aa)
CTDSPL2CTD small phosphatase-like protein 2 isoform X1. (465 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
OAZ3LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 3. (186 aa)
ARHGAP44Rho GTPase-activating protein 44 isoform X1. (809 aa)
ZPR1Zinc finger protein ZPR1. (459 aa)
MIEF2Mitochondrial dynamics protein MID49 isoform X1. (460 aa)
CUNH11orf65Uncharacterized protein C11orf65 homolog. (312 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
SEC16BProtein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. (1065 aa)
EPM2ALaforin isoform X1. (331 aa)
SORL1Sortilin-related receptor isoform X1. (2211 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X3. (375 aa)
SLC35D3Solute carrier family 35 member D3. (422 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (461 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7 isoform X1. (400 aa)
BBC3Bcl-2-binding component 3. (193 aa)
TOMM7Mitochondrial import receptor subunit TOM7 homolog isoform X1. (55 aa)
SAR1BGTP-binding protein SAR1b; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
SH3TC2SH3 domain and tetratricopeptide repeat-containing protein 2 isoform X1. (1337 aa)
CHP2Calcineurin B homologous protein 2. (198 aa)
SEPT8Septin-8 isoform X8; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (524 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
SAR1AGTP-binding protein SAR1a; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
CD81Tetraspanin. (236 aa)
TMEM30ACell cycle control protein; Belongs to the CDC50/LEM3 family. (362 aa)
PTPN14Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1187 aa)
PKIGcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
RBM22pre-mRNA-splicing factor RBM22 isoform X1. (420 aa)
ERGIC3Endoplasmic reticulum-Golgi intermediate compartment protein 3. (383 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (578 aa)
YOD1Ubiquitin thioesterase OTU1. (348 aa)
TPRNucleoprotein TPR isoform X2. (2438 aa)
RAB29Ras-related protein Rab-7L1 isoform X1. (203 aa)
B3GAT3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (335 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (476 aa)
TM9SF4Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (642 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (581 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1587 aa)
LOC111186315Ran GTPase-activating protein 1. (569 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
NDEL1Nuclear distribution protein nudE-like 1 isoform X1. (346 aa)
UBE2G2Ubiquitin-conjugating enzyme E2 G2 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
MIEF1Mitochondrial dynamics protein MID51. (463 aa)
CABP1Calcium-binding protein 1 isoform X1. (427 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial isoform X1. (584 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
UBE2J1Ubiquitin-conjugating enzyme E2 J1. (318 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
TARDBPTAR DNA-binding protein 43. (414 aa)
ERLEC1Endoplasmic reticulum lectin 1 isoform X1. (492 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
NF1Neurofibromin isoform X1. (2873 aa)
MYO1CUnconventional myosin-Ic isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (231 aa)
ITGB1BP1Integrin beta-1-binding protein 1 isoform X1. (206 aa)
FYNTyrosine-protein kinase. (537 aa)
SH3TC1SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X1. (1320 aa)
ZFAND1AN1-type zinc finger protein 1 isoform X1. (267 aa)
PRR5LProline-rich protein 5-like isoform X1. (428 aa)
RIPOR1Rho family-interacting cell polarization regulator 1 isoform X1. (1331 aa)
ICE1Little elongation complex subunit 1 isoform X1. (2241 aa)
UBR5E3 ubiquitin-protein ligase UBR5 isoform X1. (2798 aa)
PDZK1Na(+)/H(+) exchange regulatory cofactor NHE-RF3 isoform X1. (518 aa)
SVIPSmall VCP/p97-interacting protein. (77 aa)
LOC111177759LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 2-like. (189 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (294 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
OAZ2LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 2. (189 aa)
MDFImyoD family inhibitor isoform X1. (302 aa)
C2CD5C2 domain-containing protein 5 isoform X1. (1051 aa)
RAB23Ras-related protein Rab-23. (237 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CDK5Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
SLC51BLOW QUALITY PROTEIN: organic solute transporter subunit beta. (130 aa)
DMAP1DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa)
EFCAB7EF-hand calcium-binding domain-containing protein 7 isoform X1. (656 aa)
LOC111177285TRPM8 channel-associated factor 2-like. (919 aa)
LCP1Plastin-2. (627 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
IPO5Importin-5. (1097 aa)
TCAF1TRPM8 channel-associated factor 1 isoform X1. (1016 aa)
HYAL2Hyaluronidase. (476 aa)
PDCD10Programmed cell death protein 10. (212 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
ANP32BAcidic leucine-rich nuclear phosphoprotein 32 family member B. (261 aa)
GCC2GRIP and coiled-coil domain-containing protein 2 isoform X1. (1680 aa)
XPO1Exportin-1 isoform X1. (1071 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (707 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (451 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
PARK7Protein DJ-1. (189 aa)
ObLeptin isoform X1. (167 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PARLPresenilins-associated rhomboid-like protein, mitochondrial isoform X1. (379 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (660 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
SIAH3E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (269 aa)
XPO4Exportin-4 isoform X1. (1152 aa)
OS9Protein OS-9 isoform X1. (668 aa)
FERMT1Fermitin family homolog 1. (677 aa)
LOC111174204Small VCP/p97-interacting protein. (77 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2 isoform X1. (2527 aa)
GRASPLOW QUALITY PROTEIN: general receptor for phosphoinositides 1-associated scaffold protein. (399 aa)
DNAJC27dnaJ homolog subfamily C member 27 isoform X1. (273 aa)
UBAC2LOW QUALITY PROTEIN: ubiquitin-associated domain-containing protein 2. (395 aa)
FRAT1Proto-oncogene FRAT1. (279 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X2. (958 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
OAZ1LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 1. (227 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (668 aa)
ECT2Protein ECT2 isoform X1. (973 aa)
PCM1Pericentriolar material 1 protein isoform X1. (2196 aa)
MFFMitochondrial fission factor isoform X1. (353 aa)
JUPJunction plakoglobin. (744 aa)
CEMIPCell migration-inducing and hyaluronan-binding protein. (1431 aa)
PPM1AProtein phosphatase 1A. (382 aa)
TMEM30BCell cycle control protein; Belongs to the CDC50/LEM3 family. (353 aa)
AKAP5A-kinase anchor protein 5. (428 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
BAG3BAG family molecular chaperone regulator 3. (577 aa)
APODApolipoprotein D. (213 aa)
UHMK1Serine/threonine-protein kinase Kist. (419 aa)
TRIM28Transcription intermediary factor 1-beta. (837 aa)
DMTNDematin isoform X1. (405 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1; Belongs to the protein kinase superfamily. (370 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (447 aa)
LOC111170664Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
EMDEmerin isoform X1. (261 aa)
FLNAfilamin-A isoform X1. (2647 aa)
BCAP31B-cell receptor-associated protein 31. (245 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
PDCD5Programmed cell death protein 5. (125 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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