(25 nodes) Regulation of osteoblast proliferation network (Delphinapterus leucas)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	SOX8	Transcription factor SOX-8. (463 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1622 aa)
	NPR3	Atrial natriuretic peptide receptor 3. (536 aa)
	HPSE	Heparanase isoform X1. (542 aa)
	TMEM119	Transmembrane protein 119. (282 aa)
	NF2	Merlin isoform X3. (619 aa)
	MN1	Transcriptional activator MN1. (1314 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	TNN	tenascin-N. (1296 aa)
	GATA1	Erythroid transcription factor isoform X1. (426 aa)
	ITGAV	Integrin alpha-V isoform X2; Belongs to the integrin alpha chain family. (1048 aa)
	SFRP1	Secreted frizzled-related protein 1. (308 aa)
	PLXNB1	plexin-B1 isoform X1. (2182 aa)
	EIF2AK2	Interferon-induced, double-stranded RNA-activated protein kinase isoform X1. (539 aa)
	RHOA	Transforming protein RhoA. (193 aa)
	LTF	Lactotransferrin; Belongs to the transferrin family. (710 aa)
	ATRAID	All-trans retinoic acid-induced differentiation factor. (229 aa)
	CYR61	Protein CYR61. (382 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	ABL1	Tyrosine-protein kinase. (1148 aa)
	CTHRC1	Collagen triple helix repeat-containing protein 1. (285 aa)
	BCL2	Apoptosis regulator Bcl-2. (233 aa)
	GREM1	Gremlin. (184 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (789 aa)
	AXIN2	Axin-2 isoform X1. (843 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	LRP5	A0A2Y9PJS0	A0A2Y9PUA1	Axin-2 isoform X1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.855
AXIN2	SFRP1	A0A2Y9PJS0	A0A2Y9MX43	Axin-2 isoform X1.	Secreted frizzled-related protein 1.	0.624
BCL2	RHOA	A0A2Y9P9P5	A0A2Y9NBP6	Apoptosis regulator Bcl-2.	Transforming protein RhoA.	0.565
BCL2	SMAD3	A0A2Y9P9P5	A0A2Y9NWL7	Apoptosis regulator Bcl-2.	Mothers against decapentaplegic homolog.	0.450
BMP2	GREM1	A0A2Y9LYV6	A0A2Y9P9X1	Bone morphogenetic protein 2.	Gremlin.	0.947
BMP2	SMAD3	A0A2Y9LYV6	A0A2Y9NWL7	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.591
CYR61	NF2	A0A2Y9NUK7	A0A2Y9LH85	Protein CYR61.	Merlin isoform X3.	0.436
GREM1	BMP2	A0A2Y9P9X1	A0A2Y9LYV6	Gremlin.	Bone morphogenetic protein 2.	0.947
ITGAV	ITGB3	A0A2Y9MPN9	A0A2Y9PCY7	Integrin alpha-V isoform X2; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.999
ITGAV	RHOA	A0A2Y9MPN9	A0A2Y9NBP6	Integrin alpha-V isoform X2; Belongs to the integrin alpha chain family.	Transforming protein RhoA.	0.490
ITGAV	TNN	A0A2Y9MPN9	A0A2Y9M4K9	Integrin alpha-V isoform X2; Belongs to the integrin alpha chain family.	tenascin-N.	0.939
ITGB3	ITGAV	A0A2Y9PCY7	A0A2Y9MPN9	Integrin beta; Belongs to the integrin beta chain family.	Integrin alpha-V isoform X2; Belongs to the integrin alpha chain family.	0.999
ITGB3	RHOA	A0A2Y9PCY7	A0A2Y9NBP6	Integrin beta; Belongs to the integrin beta chain family.	Transforming protein RhoA.	0.630
ITGB3	TNN	A0A2Y9PCY7	A0A2Y9M4K9	Integrin beta; Belongs to the integrin beta chain family.	tenascin-N.	0.943
LRP5	AXIN2	A0A2Y9PUA1	A0A2Y9PJS0	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Axin-2 isoform X1.	0.855
LRP5	LTF	A0A2Y9PUA1	A0A2Y9NC95	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Lactotransferrin; Belongs to the transferrin family.	0.538
LRP5	SFRP1	A0A2Y9PUA1	A0A2Y9MX43	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Secreted frizzled-related protein 1.	0.626
LTF	LRP5	A0A2Y9NC95	A0A2Y9PUA1	Lactotransferrin; Belongs to the transferrin family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.538
NF2	CYR61	A0A2Y9LH85	A0A2Y9NUK7	Merlin isoform X3.	Protein CYR61.	0.436
NF2	RHOA	A0A2Y9LH85	A0A2Y9NBP6	Merlin isoform X3.	Transforming protein RhoA.	0.443