STRINGSTRING
SUPT6H SUPT6H NELFCD NELFCD ZMYND11 ZMYND11 ELL ELL BRD4 BRD4 GTF2F1 GTF2F1 NELFA NELFA SUPT4H1 SUPT4H1 EAF1 EAF1 CDK12 CDK12 CTNNB1 CTNNB1 EAF2 EAF2 NELFE NELFE PWWP2B PWWP2B RNF168 RNF168 PWWP2A PWWP2A LDB1 LDB1 EAPP EAPP CCNT1 CCNT1 WDR43 WDR43 MED8 MED8 CCNK CCNK SHH SHH NELFB NELFB LEO1 LEO1 CDK9 CDK9 HNRNPU HNRNPU LOC111177621 LOC111177621 EZH2 EZH2 CDC73 CDC73 RNF8 RNF8 USP10 USP10 ELL3 ELL3 SUPT16H SUPT16H CDK13 CDK13 BTBD18 BTBD18 RECQL5 RECQL5 ELL2 ELL2 AXIN1 AXIN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
NELFCDNegative elongation factor C/D isoform X1. (616 aa)
ZMYND11Zinc finger MYND domain-containing protein 11 isoform X1. (617 aa)
ELLRNA polymerase II elongation factor ELL isoform X1. (626 aa)
BRD4Bromodomain-containing protein 4 isoform X1. (1445 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (518 aa)
NELFANegative elongation factor A. (534 aa)
SUPT4H1Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (117 aa)
EAF1ELL-associated factor 1. (380 aa)
CDK12Cyclin-dependent kinase 12 isoform X1. (1490 aa)
CTNNB1Catenin beta-1. (781 aa)
EAF2ELL-associated factor 2. (264 aa)
NELFENegative elongation factor E isoform X2. (372 aa)
PWWP2BPWWP domain-containing protein 2B. (559 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (592 aa)
PWWP2APWWP domain-containing protein 2A isoform X1. (757 aa)
LDB1LIM domain-binding protein 1 isoform X3. (436 aa)
EAPPE2F-associated phosphoprotein. (286 aa)
CCNT1cyclin-T1; Belongs to the cyclin family. (727 aa)
WDR43WD repeat-containing protein 43. (678 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (271 aa)
CCNKcyclin-K; Belongs to the cyclin family. (582 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
NELFBNegative elongation factor B isoform X2. (580 aa)
LEO1RNA polymerase-associated protein LEO1 isoform X1. (672 aa)
CDK9Cyclin-dependent kinase 9 isoform X2; Belongs to the protein kinase superfamily. (488 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
LOC111177621RNA polymerase-associated protein LEO1-like. (292 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (747 aa)
CDC73Parafibromin. (531 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (845 aa)
ELL3RNA polymerase II elongation factor ELL3 isoform X2. (397 aa)
SUPT16HFACT complex subunit SPT16. (1047 aa)
CDK13Cyclin-dependent kinase 13 isoform X1. (1517 aa)
BTBD18BTB/POZ domain-containing protein 18. (711 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa)
ELL2RNA polymerase II elongation factor ELL2 isoform X1. (640 aa)
AXIN1Axin-1 isoform X1. (866 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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