(102 nodes) Positive regulation of ion transmembrane transport network (Delphinapterus leucas)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	TCAF1	TRPM8 channel-associated factor 1 isoform X1. (1016 aa)
	LRRC26	Leucine-rich repeat-containing protein 26. (417 aa)
	LOC111177285	TRPM8 channel-associated factor 2-like. (919 aa)
	BAK1	Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
	CALM1	Calmodulin-1; Belongs to the calmodulin family. (149 aa)
	SLC17A8	Vesicular glutamate transporter 3. (589 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
	WNK1	Serine/threonine-protein kinase WNK1 isoform X1. (2825 aa)
	PKD2	Polycystin-2 isoform X1. (975 aa)
	KCNH2	Potassium voltage-gated channel subfamily H member 2 isoform X2. (1160 aa)
	LOC111176900	GTPase IMAP family member 5-like isoform X1. (332 aa)
	FAM173B	Protein FAM173B isoform X1. (263 aa)
	LOC111179712	Neuropeptide S receptor-like. (99 aa)
	ABL1	Tyrosine-protein kinase. (1148 aa)
	PDZK1	Na(+)/H(+) exchange regulatory cofactor NHE-RF3 isoform X1. (518 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
	RAB44	Ras-related protein Rab-44 isoform X1. (1086 aa)
	THY1	Thy-1 membrane glycoprotein. (161 aa)
	TRPC6	Short transient receptor potential channel 6 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (932 aa)
	DRD4	D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (521 aa)
	LOC111170125	Myosin light chain 1, skeletal muscle isoform-like isoform X1; Belongs to the calmodulin family. (304 aa)
	STIM1	Stromal interaction molecule 1 isoform X1. (717 aa)
	FLNA	filamin-A isoform X1. (2647 aa)
	LOC111167816	Cytochrome c oxidase copper chaperone. (63 aa)
	STIM2	Stromal interaction molecule 2. (830 aa)
	WNK2	Serine/threonine-protein kinase WNK2 isoform X1. (2245 aa)
	KCNIP2	Kv channel-interacting protein 2 isoform X3. (285 aa)
	STAC3	SH3 and cysteine-rich domain-containing protein 3 isoform X1. (360 aa)
	CACNB3	Voltage-dependent L-type calcium channel subunit beta-3 isoform X1. (484 aa)
	HSPA2	Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (638 aa)
	R3HDM2	R3H domain-containing protein 2 isoform X1. (1048 aa)
	R3HDM1	R3H domain-containing protein 1 isoform X1. (1129 aa)
	AMIGO3	Amphoterin-induced protein 3. (509 aa)
	APOPT1	Apoptogenic protein 1, mitochondrial isoform X2. (233 aa)
	VMP1	Vacuole membrane protein 1. (406 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
	EPHB2	Ephrin type-B receptor 2 isoform X1. (987 aa)
	ACTN2	Alpha-actinin-2. (894 aa)
	AKAP6	A-kinase anchor protein 6 isoform X1. (2322 aa)
	RELN	Reelin isoform X1. (3460 aa)
	STAC	SH3 and cysteine-rich domain-containing protein isoform X1. (402 aa)
	ARC	Activity-regulated cytoskeleton-associated protein. (396 aa)
	CEMIP	Cell migration-inducing and hyaluronan-binding protein. (1431 aa)
	KCNE1	Potassium voltage-gated channel subfamily E member 1. (129 aa)
	RYR2	Ryanodine receptor 2 isoform X1. (4965 aa)
	HTT	Huntingtin isoform X9. (3125 aa)
	F2RL3	Proteinase-activated receptor 4; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	STAC2	SH3 and cysteine-rich domain-containing protein 2 isoform X1. (409 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (399 aa)
	HAP1	LOW QUALITY PROTEIN: huntingtin-associated protein 1. (651 aa)
	CXCR3	C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	KCNE5	Potassium voltage-gated channel subfamily E regulatory beta subunit 5. (145 aa)
	ACE2	Angiotensin-converting enzyme. (804 aa)
	TRDN	Triadin. (283 aa)
	GRM6	Metabotropic glutamate receptor 6. (870 aa)
	CXCL9	C-X-C motif chemokine. (160 aa)
	TESC	Calcineurin B homologous protein 3. (214 aa)
	EDNRA	Endothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	WNK3	Serine/threonine-protein kinase WNK3 isoform X1. (1780 aa)
	CXCL11	C-X-C motif chemokine 11. (100 aa)
	RNF207	RING finger protein 207. (633 aa)
	TRPC3	LOW QUALITY PROTEIN: short transient receptor potential channel 3; Belongs to the transient receptor (TC 1.A.4) family. (920 aa)
	LRRC38	Leucine-rich repeat-containing protein 38. (300 aa)
	CXCL10	C-X-C motif chemokine. (103 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
	F2R	Proteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains protein 3 isoform X1. (1733 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	RAMP3	Receptor activity-modifying protein 3. (151 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	DRD1	D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	ADRB2	Beta-2 adrenergic receptor isoform X1. (400 aa)
	LOC111183908	B-lymphocyte antigen CD20-like. (303 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1006 aa)
	KCNQ1	Potassium voltage-gated channel subfamily KQT member 1 isoform X1; Belongs to the potassium channel family. (673 aa)
	LRRC55	Leucine-rich repeat-containing protein 55. (318 aa)
	GALR2	Galanin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (397 aa)
	CAPN3	Calpain-3 isoform X4; Belongs to the peptidase C2 family. (822 aa)
	EDN1	Endothelin-1. (202 aa)
	CHP2	Calcineurin B homologous protein 2. (198 aa)
	AKAP9	A-kinase anchor protein 9 isoform X1. (3902 aa)
	CHP1	Calcineurin B homologous protein 1. (195 aa)
	SRI	Sorcin. (198 aa)
	CD19	B-lymphocyte antigen CD19 isoform X1. (570 aa)
	TRPC1	Short transient receptor potential channel 1 isoform X2; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
	FXYD1	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
	NDUFA4	Cytochrome c oxidase subunit NDUFA4. (82 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (294 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1482 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	AMIGO1	Amphoterin-induced protein 1. (493 aa)
	LRRC52	Leucine-rich repeat-containing protein 52. (315 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (340 aa)
	GPER1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	ANO6	Anoctamin. (951 aa)
	CRACR2A	EF-hand calcium-binding domain-containing protein 4B isoform X1. (722 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	EPHB2	A0A2Y9NX24	A0A2Y9LFX1	Tyrosine-protein kinase.	Ephrin type-B receptor 2 isoform X1.	0.927
ACE2	CTSS	A0A2Y9M9H3	A0A2Y9MDS1	Angiotensin-converting enzyme.	Cathepsin S; Belongs to the peptidase C1 family.	0.643
ACE2	EDN1	A0A2Y9M9H3	A0A2Y9PHR8	Angiotensin-converting enzyme.	Endothelin-1.	0.495
ACTN2	CASQ1	A0A2Y9LH21	A0A2Y9M2N8	Alpha-actinin-2.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.632
ACTN2	RYR2	A0A2Y9LH21	A0A2Y9LTZ5	Alpha-actinin-2.	Ryanodine receptor 2 isoform X1.	0.565
ACTN2	TRDN	A0A2Y9LH21	A0A2Y9M9P8	Alpha-actinin-2.	Triadin.	0.461
ADRB2	EDN1	A0A2Y9PQW9	A0A2Y9PHR8	Beta-2 adrenergic receptor isoform X1.	Endothelin-1.	0.742
AKAP6	PKD2	A0A2Y9LHV2	A0A2Y9NVD4	A-kinase anchor protein 6 isoform X1.	Polycystin-2 isoform X1.	0.439
AKAP6	RYR2	A0A2Y9LHV2	A0A2Y9LTZ5	A-kinase anchor protein 6 isoform X1.	Ryanodine receptor 2 isoform X1.	0.552
AKAP9	KCNE1	A0A2Y9PEY6	A0A2Y9LTJ4	A-kinase anchor protein 9 isoform X1.	Potassium voltage-gated channel subfamily E member 1.	0.630
AKAP9	KCNE5	A0A2Y9PEY6	A0A2Y9M4Y7	A-kinase anchor protein 9 isoform X1.	Potassium voltage-gated channel subfamily E regulatory beta subunit 5.	0.446
AKAP9	KCNQ1	A0A2Y9PEY6	A0A2Y9PLZ2	A-kinase anchor protein 9 isoform X1.	Potassium voltage-gated channel subfamily KQT member 1 isoform X1; Belongs to the potassium channel family.	0.827
ANO6	ATP1B3	A0A2Y9NFQ2	A0A2Y9P4T3	Anoctamin.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.582
ARC	PSEN1	A0A2Y9LR41	A0A2Y9NSH6	Activity-regulated cytoskeleton-associated protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.400
ATP1B1	ATP1B2	A0A2Y9M1I8	A0A2Y9PXG8	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.955
ATP1B1	ATP1B3	A0A2Y9M1I8	A0A2Y9P4T3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.946
ATP1B1	FXYD1	A0A2Y9M1I8	A0A2Y9P7Y1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.947
ATP1B1	SLC9A1	A0A2Y9M1I8	A0A2Y9LFT1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.417
ATP1B2	ATP1B1	A0A2Y9PXG8	A0A2Y9M1I8	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.955
ATP1B2	ATP1B3	A0A2Y9PXG8	A0A2Y9P4T3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.941