STRINGSTRING
LDB1 LDB1 NIPBL NIPBL SALL4 SALL4 LRP5 LRP5 MED7 MED7 ASCL2 ASCL2 FGF4 FGF4 LOC111182889 LOC111182889 KLF10 KLF10 MED27 MED27 LOC111176553 LOC111176553 BRAF BRAF MED21 MED21 LIG4 LIG4 CUL4A CUL4A ZFP36L2 ZFP36L2 LOC111176725 LOC111176725 SIX2 SIX2 CDX2 CDX2 RIF1 RIF1 HES1 HES1 LDB2 LDB2 MED28 MED28 SFRP1 SFRP1 SMC1A SMC1A RAF1 RAF1 YAP1 YAP1 LOC111169240 LOC111169240 MED12 MED12 VPS72 VPS72 BCL9L BCL9L LOC111169295 LOC111169295 BMPR1A BMPR1A MED17 MED17 MED14 MED14 MED30 MED30 STAT3 STAT3 ZHX2 ZHX2 NR2E1 NR2E1 FGF10 FGF10 NOG NOG LIF LIF MED15 MED15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LDB1LIM domain-binding protein 1 isoform X3. (436 aa)
NIPBLNipped-B protein. (2803 aa)
SALL4Sal-like protein 4 isoform X1. (1055 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1622 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (233 aa)
ASCL2Achaete-scute homolog 2. (191 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
KLF10Krueppel-like factor 10 isoform X2. (494 aa)
MED27Mediator of RNA polymerase II transcription subunit 27 isoform X1. (311 aa)
LOC111176553Homeobox protein NANOG-like. (306 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (152 aa)
LIG4DNA ligase. (911 aa)
CUL4Acullin-4A; Belongs to the cullin family. (761 aa)
ZFP36L2mRNA decay activator protein ZFP36L2. (493 aa)
LOC111176725Homeobox protein NANOG-like. (245 aa)
SIX2Homeobox protein SIX2. (296 aa)
CDX2Homeobox protein CDX-2. (303 aa)
RIF1Telomere-associated protein RIF1 isoform X1. (2467 aa)
HES1Transcription factor HES-1. (280 aa)
LDB2LIM domain-binding protein 2 isoform X1. (373 aa)
MED28LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 28. (203 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (511 aa)
LOC111169240RE1-silencing transcription factor-like isoform X2. (976 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (2177 aa)
VPS72Vacuolar protein sorting-associated protein 72 homolog. (364 aa)
BCL9LB-cell CLL/lymphoma 9-like protein isoform X2. (1493 aa)
LOC111169295RE1-silencing transcription factor-like isoform X1. (981 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (651 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1453 aa)
MED30Mediator of RNA polymerase II transcription subunit 30. (178 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ZHX2Zinc fingers and homeoboxes protein 2. (838 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1 isoform X1. (385 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LIFLeukemia inhibitory factor. (202 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (742 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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