6 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
	CASP8	Caspase-8; Belongs to the peptidase C14A family. (486 aa)
	CASP10	Caspase-10; Belongs to the peptidase C14A family. (518 aa)
	LOC111185436	Tumor necrosis factor receptor superfamily member 10B-like isoform X1. (456 aa)
	LOC111185435	Tumor necrosis factor receptor superfamily member 10A-like isoform X1. (454 aa)
	LOC111184077	Tumor necrosis factor receptor superfamily member 26-like. (308 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP10	CASP8	A0A2Y9MLF7	A0A2Y9MQ94	Caspase-10; Belongs to the peptidase C14A family.	Caspase-8; Belongs to the peptidase C14A family.	0.974
CASP10	FADD	A0A2Y9MLF7	A0A2Y9PNL8	Caspase-10; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.995
CASP10	LOC111184077	A0A2Y9MLF7	A0A2Y9PXW8	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 26-like.	0.499
CASP10	LOC111185435	A0A2Y9MLF7	A0A2Y9Q5N6	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 10A-like isoform X1.	0.658
CASP10	LOC111185436	A0A2Y9MLF7	A0A2Y9Q5P0	Caspase-10; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 10B-like isoform X1.	0.658
CASP8	CASP10	A0A2Y9MQ94	A0A2Y9MLF7	Caspase-8; Belongs to the peptidase C14A family.	Caspase-10; Belongs to the peptidase C14A family.	0.974
CASP8	FADD	A0A2Y9MQ94	A0A2Y9PNL8	Caspase-8; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	LOC111184077	A0A2Y9MQ94	A0A2Y9PXW8	Caspase-8; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 26-like.	0.520
CASP8	LOC111185435	A0A2Y9MQ94	A0A2Y9Q5N6	Caspase-8; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 10A-like isoform X1.	0.658
CASP8	LOC111185436	A0A2Y9MQ94	A0A2Y9Q5P0	Caspase-8; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily member 10B-like isoform X1.	0.658
FADD	CASP10	A0A2Y9PNL8	A0A2Y9MLF7	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase-10; Belongs to the peptidase C14A family.	0.995
FADD	CASP8	A0A2Y9PNL8	A0A2Y9MQ94	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase-8; Belongs to the peptidase C14A family.	0.999
FADD	LOC111184077	A0A2Y9PNL8	A0A2Y9PXW8	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Tumor necrosis factor receptor superfamily member 26-like.	0.639
FADD	LOC111185435	A0A2Y9PNL8	A0A2Y9Q5N6	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Tumor necrosis factor receptor superfamily member 10A-like isoform X1.	0.981
FADD	LOC111185436	A0A2Y9PNL8	A0A2Y9Q5P0	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Tumor necrosis factor receptor superfamily member 10B-like isoform X1.	0.981
LOC111184077	CASP10	A0A2Y9PXW8	A0A2Y9MLF7	Tumor necrosis factor receptor superfamily member 26-like.	Caspase-10; Belongs to the peptidase C14A family.	0.499
LOC111184077	CASP8	A0A2Y9PXW8	A0A2Y9MQ94	Tumor necrosis factor receptor superfamily member 26-like.	Caspase-8; Belongs to the peptidase C14A family.	0.520
LOC111184077	FADD	A0A2Y9PXW8	A0A2Y9PNL8	Tumor necrosis factor receptor superfamily member 26-like.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.639
LOC111184077	LOC111185435	A0A2Y9PXW8	A0A2Y9Q5N6	Tumor necrosis factor receptor superfamily member 26-like.	Tumor necrosis factor receptor superfamily member 10A-like isoform X1.	0.651
LOC111184077	LOC111185436	A0A2Y9PXW8	A0A2Y9Q5P0	Tumor necrosis factor receptor superfamily member 26-like.	Tumor necrosis factor receptor superfamily member 10B-like isoform X1.	0.651