(95 nodes) Regulation of gene expression, epigenetic network (Delphinapterus leucas)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	PPM1D	Protein phosphatase 1D isoform X1. (605 aa)
	MORC2	MORC family CW-type zinc finger protein 2 isoform X1. (1064 aa)
	BEND3	BEN domain-containing protein 3. (828 aa)
	EZH1	Histone-lysine N-methyltransferase EZH1 isoform X1. (749 aa)
	KLF2	Krueppel-like factor 2. (355 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1866 aa)
	LMNA	Lamin; Belongs to the intermediate filament family. (664 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1654 aa)
	SIRT6	NAD-dependent protein deacetylase sirtuin-6 isoform X3. (375 aa)
	BMI1	Polycomb complex protein BMI-1. (326 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U isoform X1. (825 aa)
	EPC1	Enhancer of polycomb homolog. (842 aa)
	POLE3	DNA polymerase epsilon subunit 3. (147 aa)
	RLIM	E3 ubiquitin-protein ligase RLIM isoform X1. (637 aa)
	CGGBP1	CGG triplet repeat-binding protein 1. (167 aa)
	PRMT7	Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (695 aa)
	EZH2	Histone-lysine N-methyltransferase EZH2 isoform X1. (747 aa)
	LHX2	LIM/homeobox protein Lhx2. (406 aa)
	LRIF1	Ligand-dependent nuclear receptor-interacting factor 1 isoform X1. (762 aa)
	RBM15	Putative RNA-binding protein 15. (962 aa)
	CTCF	Transcriptional repressor CTCF isoform X1. (727 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
	JARID2	Protein Jumonji isoform X1. (1235 aa)
	EXOSC10	Exosome component 10. (887 aa)
	PADI2	Protein-arginine deiminase type-2. (665 aa)
	CTCFL	Transcriptional repressor CTCFL isoform X2. (615 aa)
	SMARCA5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (1052 aa)
	FAM47E	Protein FAM47E. (442 aa)
	ZNFX1	NFX1-type zinc finger-containing protein 1. (1918 aa)
	EP300	Histone acetyltransferase p300. (2420 aa)
	TFAP2C	Transcription factor AP-2 gamma. (450 aa)
	PRDM14	PR domain zinc finger protein 14. (571 aa)
	MORC1	MORC family CW-type zinc finger protein 1. (940 aa)
	ASIP	Agouti-signaling protein isoform X1. (175 aa)
	AXIN1	Axin-1 isoform X1. (866 aa)
	SUZ12	Polycomb protein SUZ12 isoform X1. (739 aa)
	CREBZF	CREB/ATF bZIP transcription factor isoform X1. (357 aa)
	FAM172A	Protein FAM172A isoform X1. (416 aa)
	LOC111182816	Histone H3; Belongs to the histone H3 family. (136 aa)
	KCNQ1	Potassium voltage-gated channel subfamily KQT member 1 isoform X1; Belongs to the potassium channel family. (673 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
	WBP2	WW domain-binding protein 2 isoform X1. (261 aa)
	LOC111183465	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	CDYL	Chromodomain Y-like protein. (544 aa)
	LOC111182462	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
	SPHK2	Sphingosine kinase 2 isoform X1. (655 aa)
	BAHD1	Bromo adjacent homology domain-containing 1 protein isoform X1. (792 aa)
	LMNB1	lamin-B1; Belongs to the intermediate filament family. (586 aa)
	SPTY2D1	LOW QUALITY PROTEIN: protein SPT2 homolog. (722 aa)
	MBD2	methyl-CpG-binding domain protein 2. (409 aa)
	METTL3	N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family. (580 aa)
	GSK3A	Glycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
	SMYD5	SET and MYND domain-containing protein 5 isoform X1. (423 aa)
	MBD3L1	LOW QUALITY PROTEIN: methyl-CpG-binding domain protein 3-like 1. (191 aa)
	YTHDC1	YTH domain-containing protein 1 isoform X1. (738 aa)
	MBD3	methyl-CpG-binding domain protein 3 isoform X1. (289 aa)
	ZFP57	Zinc finger protein 57 homolog. (590 aa)
	LOC111168424	Zinc finger protein RFP. (513 aa)
	HDAC6	Histone deacetylase 6 isoform X1. (1149 aa)
	LOC111168978	Histone H1oo. (319 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (482 aa)
	CHEK1	Serine/threonine-protein kinase Chk1 isoform X1. (540 aa)
	VPS72	Vacuolar protein sorting-associated protein 72 homolog. (364 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1123 aa)
	PHF2	Lysine-specific demethylase PHF2 isoform X1. (1100 aa)
	ZNF335	Zinc finger protein 335 isoform X1. (1346 aa)
	LOC111167944	Histone H3.3-like. (136 aa)
	LOC111171203	Centromere protein V-like. (216 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
	LOC111169588	LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RLIM-like. (657 aa)
	LOC111169704	Histone H3.3-like. (136 aa)
	NRM	Nurim isoform X1. (262 aa)
	TNP1	Spermatid nuclear transition protein 1. (55 aa)
	SUV39H1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (419 aa)
	NDN	Necdin. (325 aa)
	LMNB2	lamin-B2 isoform X1; Belongs to the intermediate filament family. (627 aa)
	ZDBF2	DBF4-type zinc finger-containing protein 2. (2435 aa)
	HAT1	Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
	BAZ2A	Bromodomain adjacent to zinc finger domain protein 2A isoform X1. (1924 aa)
	HELLS	Lymphoid-specific helicase. (837 aa)
	PCGF5	Polycomb group RING finger protein 5 isoform X1. (256 aa)
	RIF1	Telomere-associated protein RIF1 isoform X1. (2467 aa)
	PPHLN1	Periphilin-1 isoform X1. (387 aa)
	LOC111173290	LOW QUALITY PROTEIN: polycomb group RING finger protein 5-like. (257 aa)
	FAM208A	Protein TASOR isoform X5. (1624 aa)
	DNMT3A	DNA (Cytosine-5)-methyltransferase 3A isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (910 aa)
	HMGA2	High mobility group protein HMGI-C. (109 aa)
	HDAC1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
	SMARCD1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1. (515 aa)
	ARID4A	AT-rich interactive domain-containing protein 4A isoform X2. (1279 aa)
	SMCHD1	Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (2000 aa)
	LOC111164170	Histone H3.3-like. (182 aa)
	GLMN	Glomulin. (592 aa)
	PCGF3	Polycomb group RING finger protein 3 isoform X1. (270 aa)
	CTBP1	C-terminal-binding protein 1 isoform X1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (441 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	EPC1	A0A2Y9NAB1	A0A2Y9NMK4	AT-rich interactive domain-containing protein 4A isoform X2.	Enhancer of polycomb homolog.	0.624
ARID4A	EZH1	A0A2Y9NAB1	A0A2Y9LVK7	AT-rich interactive domain-containing protein 4A isoform X2.	Histone-lysine N-methyltransferase EZH1 isoform X1.	0.409
ARID4A	EZH2	A0A2Y9NAB1	A0A2Y9NXL9	AT-rich interactive domain-containing protein 4A isoform X2.	Histone-lysine N-methyltransferase EZH2 isoform X1.	0.409
ARID4A	HDAC1	A0A2Y9NAB1	A0A2Y9N7S9	AT-rich interactive domain-containing protein 4A isoform X2.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.884
ARID4A	HDAC5	A0A2Y9NAB1	A0A2Y9MFY5	AT-rich interactive domain-containing protein 4A isoform X2.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.797
ARID4A	HDAC6	A0A2Y9NAB1	A0A2Y9MBF1	AT-rich interactive domain-containing protein 4A isoform X2.	Histone deacetylase 6 isoform X1.	0.797
ARID4A	HELLS	A0A2Y9NAB1	A0A2Y9N0V4	AT-rich interactive domain-containing protein 4A isoform X2.	Lymphoid-specific helicase.	0.611
ARID4A	LOC111164170	A0A2Y9NAB1	A0A2Y9LI27	AT-rich interactive domain-containing protein 4A isoform X2.	Histone H3.3-like.	0.718
ARID4A	LOC111167944	A0A2Y9NAB1	A0A2Y9MIQ1	AT-rich interactive domain-containing protein 4A isoform X2.	Histone H3.3-like.	0.718
ARID4A	LOC111169704	A0A2Y9NAB1	A0A2Y9ML89	AT-rich interactive domain-containing protein 4A isoform X2.	Histone H3.3-like.	0.718
ARID4A	LOC111182462	A0A2Y9NAB1	A0A2Y9PFA0	AT-rich interactive domain-containing protein 4A isoform X2.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.424
ARID4A	LOC111182816	A0A2Y9NAB1	A0A2Y9PQZ8	AT-rich interactive domain-containing protein 4A isoform X2.	Histone H3; Belongs to the histone H3 family.	0.718
ARID4A	LOC111183465	A0A2Y9NAB1	A0A2Y9PHR7	AT-rich interactive domain-containing protein 4A isoform X2.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.424
ARID4A	MBD2	A0A2Y9NAB1	A0A2Y9PA38	AT-rich interactive domain-containing protein 4A isoform X2.	methyl-CpG-binding domain protein 2.	0.573
ARID4A	MBD3	A0A2Y9NAB1	A0A2Y9M632	AT-rich interactive domain-containing protein 4A isoform X2.	methyl-CpG-binding domain protein 3 isoform X1.	0.573
ARID4A	MBD3L1	A0A2Y9NAB1	A0A2Y9M5K3	AT-rich interactive domain-containing protein 4A isoform X2.	LOW QUALITY PROTEIN: methyl-CpG-binding domain protein 3-like 1.	0.573
ARID4A	MECP2	A0A2Y9NAB1	A0A2Y9MKJ4	AT-rich interactive domain-containing protein 4A isoform X2.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.573
ARID4A	METTL3	A0A2Y9NAB1	A0A2Y9P8M4	AT-rich interactive domain-containing protein 4A isoform X2.	N6-adenosine-methyltransferase 70 kDa subunit; Belongs to the MT-A70-like family.	0.410
ARID4A	SMARCA5	A0A2Y9NAB1	A0A2Y9QCQ9	AT-rich interactive domain-containing protein 4A isoform X2.	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5.	0.611
ARID4A	SMARCD1	A0A2Y9NAB1	A0A2Y9N8Z2	AT-rich interactive domain-containing protein 4A isoform X2.	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1.	0.652