33 items (Delphinapterus leucas) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRKCD	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
	JUP	Junction plakoglobin. (744 aa)
	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
	ZPR1	Zinc finger protein ZPR1. (459 aa)
	HCLS1	Hematopoietic lineage cell-specific protein. (481 aa)
	FLNA	filamin-A isoform X1. (2647 aa)
	TRIM28	Transcription intermediary factor 1-beta. (837 aa)
	BAG3	BAG family molecular chaperone regulator 3. (577 aa)
	ECT2	Protein ECT2 isoform X1. (973 aa)
	ZC3H12A	Endoribonuclease ZC3H12A. (583 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
	HYAL2	Hyaluronidase. (476 aa)
	IPO5	Importin-5. (1097 aa)
	EFCAB7	EF-hand calcium-binding domain-containing protein 7 isoform X1. (656 aa)
	DMAP1	DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa)
	SMO	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
	UBR5	E3 ubiquitin-protein ligase UBR5 isoform X1. (2798 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	CDH1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
	PTPN22	Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
	CHP2	Calcineurin B homologous protein 2. (198 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
	HDAC3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
	RBM22	pre-mRNA-splicing factor RBM22 isoform X1. (420 aa)
	TPR	Nucleoprotein TPR isoform X2. (2438 aa)
	MAVS	Mitochondrial antiviral-signaling protein isoform X1. (581 aa)
	GLI3	Transcriptional activator GLI3 isoform X1. (1587 aa)
	TARDBP	TAR DNA-binding protein 43. (414 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	Ob	Leptin isoform X1. (167 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH1	HCLS1	A0A2Y9P9K7	A0A2Y9MEZ4	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Hematopoietic lineage cell-specific protein.	0.527
CDH1	IFNG	A0A2Y9P9K7	A0A2Y9NDI2	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.435
CDH1	JUP	A0A2Y9P9K7	A0A2Y9LWI5	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Junction plakoglobin.	0.984
CDH1	PSEN1	A0A2Y9P9K7	A0A2Y9NSH6	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.548
CDH1	SHH	A0A2Y9P9K7	A0A2Y9NDZ2	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.439
CDH1	TGFB1	A0A2Y9P9K7	A0A2Y9P5D5	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.705
FLNA	HCLS1	A0A2Y9MHB6	A0A2Y9MEZ4	filamin-A isoform X1.	Hematopoietic lineage cell-specific protein.	0.490
GLI3	PIK3R1	A0A2Y9Q038	A0A2Y9Q8T5	Transcriptional activator GLI3 isoform X1.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.631
GLI3	SHH	A0A2Y9Q038	A0A2Y9NDZ2	Transcriptional activator GLI3 isoform X1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.751
GLI3	SMO	A0A2Y9Q038	A0A2Y9NPM0	Transcriptional activator GLI3 isoform X1.	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.	0.860
HCLS1	CDH1	A0A2Y9MEZ4	A0A2Y9P9K7	Hematopoietic lineage cell-specific protein.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	0.527
HCLS1	FLNA	A0A2Y9MEZ4	A0A2Y9MHB6	Hematopoietic lineage cell-specific protein.	filamin-A isoform X1.	0.490
HDAC3	JUP	A0A2Y9PRW8	A0A2Y9LWI5	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Junction plakoglobin.	0.480
HYAL2	IFNG	A0A2Y9NHI0	A0A2Y9NDI2	Hyaluronidase.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.437
IFNG	CDH1	A0A2Y9NDI2	A0A2Y9P9K7	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	0.435
IFNG	HYAL2	A0A2Y9NDI2	A0A2Y9NHI0	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Hyaluronidase.	0.437
IFNG	LEP	A0A2Y9NDI2	A0A2Y9PHF5	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.438
IFNG	MAVS	A0A2Y9NDI2	A0A2Y9PZ49	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Mitochondrial antiviral-signaling protein isoform X1.	0.508
IFNG	Ob	A0A2Y9NDI2	G8DLG4	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Leptin isoform X1.	0.438
IFNG	TGFB1	A0A2Y9NDI2	A0A2Y9P5D5	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.650