STRINGSTRING
EPHA2 EPHA2 FGR FGR UMOD UMOD AKIRIN2 AKIRIN2 IL22RA1 IL22RA1 LOC111164047 LOC111164047 COCH COCH PRKD1 PRKD1 MYD88 MYD88 GSDMC GSDMC MPO MPO NOD2 NOD2 PLA2G1B PLA2G1B GSDMD GSDMD IFNE IFNE LPO LPO LOC111165710 LOC111165710 GBP6 GBP6 PENK PENK RNF31 RNF31 FCER1G FCER1G S100A14 S100A14 IL27RA IL27RA SHC1 SHC1 APOA2 APOA2 LOC111167004 LOC111167004 ADGRB1 ADGRB1 SHARPIN SHARPIN IL18 IL18 LOC111167555 LOC111167555 MARCH2 MARCH2 CUNH10orf99 CUNH10orf99 PGLYRP2 PGLYRP2 LYPD8 LYPD8 WFDC2 WFDC2 SYK SYK AZU1 AZU1 ELANE ELANE DROSHA DROSHA IL12B IL12B LOC111170141 LOC111170141 NLRP6 NLRP6 DHX15 DHX15 LTA LTA LOC111169915 LOC111169915 SLC11A1 SLC11A1 WFDC3 WFDC3 DEFB1 DEFB1 LOC111173353 LOC111173353 LYZ LYZ LOC111173594 LOC111173594 LOC111171039 LOC111171039 STAB1 STAB1 ADAMTS5 ADAMTS5 NLRC4 NLRC4 TMF1 TMF1 CHGA CHGA PRKCD PRKCD TUSC2 TUSC2 CAMP CAMP LTF LTF TBK1 TBK1 LOC111176919 LOC111176919 IL12A IL12A RARRES2 RARRES2 TLR5 TLR5 AICDA AICDA TLR4 TLR4 LOC111176721 LOC111176721 IL17A IL17A MORN5 MORN5 CARD9 CARD9 RAB14 RAB14 TNFRSF1A TNFRSF1A IL17F IL17F IRF8 IRF8 LCN2 LCN2 TNFSF8 TNFSF8 TF TF LOC111177936 LOC111177936 TREM2 TREM2 NOD1 NOD1 C5AR1 C5AR1 LOC111179199 LOC111179199 BCL3 BCL3 COLEC12 COLEC12 LOC111179563 LOC111179563 RNASE13 RNASE13 AQP1 AQP1 RAG2 RAG2 PYCARD PYCARD NOTCH2 NOTCH2 RNASE6 RNASE6 LEAP2 LEAP2 PGLYRP1 PGLYRP1 RNASE4 RNASE4 SPN SPN LGALS4 LGALS4 HAMP HAMP RNASE2 RNASE2 LOC111183561 LOC111183561 LYZL6 LYZL6 LOC111181594 LOC111181594 RNASE12 RNASE12 ANG ANG ZG16 ZG16 ROMO1 ROMO1 SCNN1B SCNN1B BPIFA1 BPIFA1 DEFB125 DEFB125 DEFB129 DEFB129 LOC111182532 LOC111182532 MPEG1 MPEG1 BPI BPI LOC111184435 LOC111184435 BPIFA2 BPIFA2 DEFB128 DEFB128 F2 F2 LBP LBP HMGB2 HMGB2 DEFB124 DEFB124 RBCK1 RBCK1 MAVS MAVS PI3 PI3 LOC111185785 LOC111185785 RAB1A RAB1A LOC111185989 LOC111185989 P2RX7 P2RX7 CST11 CST11 DEFB136 DEFB136 ZNFX1 ZNFX1 CEBPB CEBPB IL7R IL7R JCHAIN JCHAIN FGB FGB NR1H4 NR1H4 PLA2G6 PLA2G6 ANXA3 ANXA3 ANKRD17 ANKRD17 STAB2 STAB2 LOC111187154 LOC111187154 CXCL13 CXCL13 PLAC8 PLAC8 TLR2 TLR2 TNF TNF IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHA2Ephrin type-A receptor 2. (975 aa)
FGRTyrosine-protein kinase. (526 aa)
UMODUromodulin. (643 aa)
AKIRIN2Akirin-2. (203 aa)
IL22RA1Interleukin-22 receptor subunit alpha-1. (581 aa)
LOC111164047Guanylate-binding protein 4-like isoform X1. (638 aa)
COCHCochlin. (551 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
GSDMCLOW QUALITY PROTEIN: gasdermin-C. (266 aa)
MPOMyeloperoxidase. (719 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
PLA2G1BPhospholipase A(2). (160 aa)
GSDMDgasdermin-D isoform X1. (487 aa)
IFNEInterferon epsilon. (193 aa)
LPOLactoperoxidase isoform X2. (712 aa)
LOC111165710LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein; Belongs to the MHC class I family. (254 aa)
GBP6Guanylate-binding protein 6. (629 aa)
PENKproenkephalin-A. (263 aa)
RNF31E3 ubiquitin-protein ligase RNF31 isoform X1. (1094 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
S100A14Protein S100-A14; Belongs to the S-100 family. (104 aa)
IL27RAInterleukin-27 receptor subunit alpha isoform X1. (656 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
APOA2Apolipoprotein A-II. (103 aa)
LOC111167004LOW QUALITY PROTEIN: peptidoglycan recognition protein 3-like. (277 aa)
ADGRB1Brain-specific angiogenesis inhibitor 1 isoform X1. (888 aa)
SHARPINSharpin isoform X1. (484 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
LOC111167555Caspase-13 isoform X1; Belongs to the peptidase C14A family. (377 aa)
MARCH2E3 ubiquitin-protein ligase MARCH2. (246 aa)
CUNH10orf99Secreted protein C10orf99 homolog. (81 aa)
PGLYRP2N-acetylmuramoyl-L-alanine amidase isoform X1. (581 aa)
LYPD8ly6/PLAUR domain-containing protein 8. (329 aa)
WFDC2WAP four-disulfide core domain protein 2. (123 aa)
SYKTyrosine-protein kinase. (626 aa)
AZU1Azurocidin. (252 aa)
ELANENeutrophil elastase; Belongs to the peptidase S1 family. (308 aa)
DROSHARibonuclease 3 isoform X1. (1414 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
LOC111170141WAP four-disulfide core domain protein 2-like. (103 aa)
NLRP6LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6. (876 aa)
DHX15pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15. (795 aa)
LTALymphotoxin-alpha; Belongs to the tumor necrosis factor family. (205 aa)
LOC11116991560S ribosomal protein L30-like. (115 aa)
SLC11A1Natural resistance-associated macrophage protein 1 isoform X1. (546 aa)
WFDC3WAP four-disulfide core domain protein 3 isoform X1. (137 aa)
DEFB1Beta-defensin 1 isoform X1. (108 aa)
LOC111173353Beta-defensin 103A-like. (67 aa)
LYZLysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family. (168 aa)
LOC111173594Beta-defensin 130-like. (79 aa)
LOC111171039Protegrin-2-like isoform X1. (218 aa)
STAB1Stabilin-1 isoform X1. (2596 aa)
ADAMTS5A disintegrin and metalloproteinase with thrombospondin motifs 5. (931 aa)
NLRC4NLR family CARD domain-containing protein 4 isoform X1. (1024 aa)
TMF1TATA element modulatory factor isoform X1. (1093 aa)
CHGAchromogranin-A isoform X1. (445 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
TUSC2Tumor suppressor candidate 2. (110 aa)
CAMPCathelicidin antimicrobial peptide isoform X1. (162 aa)
LTFLactotransferrin; Belongs to the transferrin family. (710 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
LOC11117691960S ribosomal protein L30-like. (115 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
RARRES2Retinoic acid receptor responder protein 2. (166 aa)
TLR5Toll-like receptor 5; Belongs to the Toll-like receptor family. (858 aa)
AICDASingle-stranded DNA cytosine deaminase. (208 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
LOC111176721C-type lectin domain family 4 member E-like. (212 aa)
IL17Ainterleukin-17A. (155 aa)
MORN5MORN repeat-containing protein 5 isoform X1. (172 aa)
CARD9Caspase recruitment domain-containing protein 9 isoform X1. (539 aa)
RAB14Ras-related protein Rab-14. (215 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
IL17Finterleukin-17F. (165 aa)
IRF8Interferon regulatory factor 8 isoform X1. (427 aa)
LCN2Neutrophil gelatinase-associated lipocalin; Belongs to the calycin superfamily. Lipocalin family. (199 aa)
TNFSF8Tumor necrosis factor ligand superfamily member 8 isoform X1; Belongs to the tumor necrosis factor family. (234 aa)
TFSerotransferrin; Belongs to the transferrin family. (702 aa)
LOC11117793660S ribosomal protein L30-like. (122 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (424 aa)
LOC111179199Serotransferrin-like; Belongs to the transferrin family. (706 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
COLEC12Collectin-12. (742 aa)
LOC111179563Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. (345 aa)
RNASE13Probable inactive ribonuclease-like protein 13; Belongs to the pancreatic ribonuclease family. (187 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
RAG2V(D)J recombination-activating protein 2. (527 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
RNASE6Ribonuclease K6; Belongs to the pancreatic ribonuclease family. (154 aa)
LEAP2Liver-expressed antimicrobial peptide 2. (77 aa)
PGLYRP1LOW QUALITY PROTEIN: peptidoglycan recognition protein 1. (185 aa)
RNASE4Ribonuclease 4; Belongs to the pancreatic ribonuclease family. (147 aa)
SPNLeukosialin. (411 aa)
LGALS4Galectin. (323 aa)
HAMPHepcidin isoform X2. (108 aa)
RNASE2Non-secretory ribonuclease; Belongs to the pancreatic ribonuclease family. (158 aa)
LOC111183561Mannose-binding protein A-like isoform X1. (265 aa)
LYZL6Lysozyme-like protein 6; Belongs to the glycosyl hydrolase 22 family. (126 aa)
LOC111181594Ribonuclease 7-like; Belongs to the pancreatic ribonuclease family. (156 aa)
RNASE12Probable inactive ribonuclease-like protein 12; Belongs to the pancreatic ribonuclease family. (198 aa)
ANGAngiogenin isoform X1; Belongs to the pancreatic ribonuclease family. (225 aa)
ZG16Zymogen granule membrane protein 16 isoform X1. (189 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
SCNN1BAmiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (641 aa)
BPIFA1BPI fold-containing family A member 1. (263 aa)
DEFB125Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (123 aa)
DEFB129Beta-defensin 129. (167 aa)
LOC111182532Ankyrin repeat and KH domain-containing protein 1 isoform X1. (2642 aa)
MPEG1Macrophage-expressed gene 1 protein. (717 aa)
BPIBactericidal permeability-increasing protein isoform X1. (483 aa)
LOC111184435Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
BPIFA2LOW QUALITY PROTEIN: BPI fold-containing family A member 2. (243 aa)
DEFB128Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (94 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
LBPLipopolysaccharide-binding protein isoform X1. (537 aa)
HMGB2High mobility group protein B2. (210 aa)
DEFB124Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (70 aa)
RBCK1ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1. (550 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (581 aa)
PI3Elafin. (115 aa)
LOC111185785Baculoviral IAP repeat-containing protein 1 isoform X1. (1759 aa)
RAB1ARas-related protein Rab-1A. (205 aa)
LOC111185989Nitric oxide synthase; Produces nitric oxide (NO). (1146 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
CST11Cystatin-11. (137 aa)
DEFB136Beta-defensin 136. (75 aa)
ZNFX1NFX1-type zinc finger-containing protein 1. (1918 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
IL7RInterleukin-7 receptor subunit alpha isoform X1. (459 aa)
JCHAINImmunoglobulin J chain. (158 aa)
FGBFibrinogen beta chain isoform X1. (495 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2 isoform X2. (835 aa)
ANXA3Annexin. (323 aa)
ANKRD17Ankyrin repeat domain-containing protein 17 isoform X1. (2618 aa)
STAB2Stabilin-2 isoform X1. (2663 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
CXCL13C-X-C motif chemokine 13. (109 aa)
PLAC8Placenta-specific gene 8 protein. (113 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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