STRINGSTRING
ABL1 ABL1 DAB2IP DAB2IP TERF2IP TERF2IP CUNH18orf32 CUNH18orf32 UNC5CL UNC5CL TREM2 TREM2 NFKBIB NFKBIB BCL10 BCL10 CTH CTH NOD1 NOD1 DHX36 DHX36 RIOK3 RIOK3 TRADD TRADD USP10 USP10 TRAF6 TRAF6 PYCARD PYCARD RIPK1 RIPK1 NUP62 NUP62 SPHK2 SPHK2 HSPB1 HSPB1 PPM1N PPM1N PRKCB PRKCB CAPN3 CAPN3 MAPKBP1 MAPKBP1 CD74 CD74 TNIP1 TNIP1 SIRT1 SIRT1 MAP3K3 MAP3K3 FADD FADD LOC111182532 LOC111182532 RELA RELA DDX21 DDX21 RBCK1 RBCK1 TNIP3 TNIP3 ALPK1 ALPK1 TRAF5 TRAF5 IKBKE IKBKE JMJD8 JMJD8 F2R F2R NLRC3 NLRC3 PDPK1 PDPK1 S100B S100B TRAF4 TRAF4 NR1H4 NR1H4 TIFA TIFA REL REL PELI1 PELI1 ANKRD17 ANKRD17 TNF TNF IL1B IL1B CCL19 CCL19 PINK1 PINK1 F2RL1 F2RL1 CCL21 CCL21 TRIM25 TRIM25 UFL1 UFL1 LITAF LITAF PRKD1 PRKD1 AJUBA AJUBA MAP3K7 MAP3K7 MYD88 MYD88 TRAF3IP2 TRAF3IP2 FYN FYN TNIP2 TNIP2 NOD2 NOD2 TIRAP TIRAP ZMYND11 ZMYND11 MID2 MID2 RNF31 RNF31 NR1D1 NR1D1 TNFAIP3 TNFAIP3 DDX1 DDX1 WDR83 WDR83 TAB2 TAB2 BTNL9 BTNL9 NKIRAS2 NKIRAS2 ZFAND6 ZFAND6 S100A13 S100A13 SHARPIN SHARPIN S100A4 S100A4 ESR1 ESR1 NLRX1 NLRX1 LOC111165753 LOC111165753 CACTIN CACTIN ATP2C1 ATP2C1 CUNH1orf106 CUNH1orf106 TAB3 TAB3 LOC111168424 LOC111168424 S100A12 S100A12 ASH1L ASH1L AKAP13 AKAP13 TRIM38 TRIM38 CTNNB1 CTNNB1 TRIM68 TRIM68 LOC111169218 LOC111169218 SQSTM1 SQSTM1 EDA2R EDA2R TMEM101 TMEM101 FASLG FASLG CD40 CD40 MAP3K14 MAP3K14 TMEM106A TMEM106A AGPAT4 AGPAT4 IRAK1 IRAK1 TRIM21 TRIM21 EDA EDA NLRP6 NLRP6 CARD11 CARD11 DHX15 DHX15 CFLAR CFLAR CASP10 CASP10 STAT1 STAT1 CASP8 CASP8 LOC111171742 LOC111171742 CCDC22 CCDC22 OTUD7B OTUD7B TRIM8 TRIM8 IKBKG IKBKG BTRC BTRC PIDD1 PIDD1 RHOH RHOH PPM1A PPM1A LOC111170681 LOC111170681 TRIML2 TRIML2 CHUK CHUK TLR3 TLR3 TNFSF10 TNFSF10 IKBKB IKBKB TANK TANK TRIM59 TRIM59 HTR2B HTR2B IRAK4 IRAK4 PRKCE PRKCE WNT5A WNT5A TNFRSF19 TNFRSF19 PPM1M PPM1M TRIML1 TRIML1 TNFSF11 TNFSF11 HDAC1 HDAC1 LURAP1L LURAP1L ZC3H12A ZC3H12A PPM1B PPM1B RHOA RHOA TRIM13 TRIM13 TRAF3 TRAF3 LTF LTF TBK1 TBK1 LTBR LTBR LOC111176754 LOC111176754 TRIM32 TRIM32 TLE1 TLE1 RORA RORA TRAF2 TRAF2 TRIM62 TRIM62 LPAR1 LPAR1 LOC111177912 LOC111177912 LURAP1 LURAP1 CARD9 CARD9 ROR1 ROR1 OPTN OPTN TRAF1 TRAF1 TNFRSF1A TNFRSF1A GAPDH GAPDH PLCG2 PLCG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABL1Tyrosine-protein kinase. (1148 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1193 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1. (398 aa)
CUNH18orf32UPF0729 protein C18orf32 homolog. (76 aa)
UNC5CLUNC5C-like protein isoform X1. (518 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
NFKBIBNF-kappa-B inhibitor beta. (353 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
CTHCystathionine gamma-lyase isoform X1. (438 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (953 aa)
DHX36ATP-dependent RNA helicase DHX36 isoform X1. (1020 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (315 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (845 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa)
NUP62Nuclear pore glycoprotein p62. (516 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
PPM1NProbable protein phosphatase 1N isoform X1. (490 aa)
PRKCBProtein kinase C. (689 aa)
CAPN3Calpain-3 isoform X4; Belongs to the peptidase C2 family. (822 aa)
MAPKBP1Mitogen-activated protein kinase-binding protein 1 isoform X1. (1510 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
TNIP1TNFAIP3-interacting protein 1 isoform X1. (634 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3 isoform X1. (657 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
LOC111182532Ankyrin repeat and KH domain-containing protein 1 isoform X1. (2642 aa)
RELATranscription factor p65 isoform X1. (562 aa)
DDX21Nucleolar RNA helicase 2. (785 aa)
RBCK1ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1. (550 aa)
TNIP3TNFAIP3-interacting protein 3 isoform X1. (375 aa)
ALPK1Alpha-protein kinase 1 isoform X1. (1244 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (616 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (807 aa)
JMJD8jmjC domain-containing protein 8 isoform X1. (280 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NLRC3NLR family CARD domain-containing protein 3 isoform X1. (1066 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
TRAF4TNF receptor-associated factor. (470 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
TIFATRAF-interacting protein with FHA domain-containing protein A. (185 aa)
RELProto-oncogene c-Rel. (594 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
ANKRD17Ankyrin repeat domain-containing protein 17 isoform X1. (2618 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
CCL19C-C motif chemokine. (159 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial isoform X1. (584 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
CCL21C-C motif chemokine 21 isoform X1. (131 aa)
TRIM25E3 ubiquitin/ISG15 ligase TRIM25 isoform X1. (634 aa)
UFL1E3 UFM1-protein ligase 1. (791 aa)
LITAFLipopolysaccharide-induced tumor necrosis factor-alpha factor isoform X1. (176 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
AJUBALIM domain-containing protein ajuba isoform X1. (557 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (564 aa)
FYNTyrosine-protein kinase. (537 aa)
TNIP2TNFAIP3-interacting protein 2 isoform X1. (434 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (226 aa)
ZMYND11Zinc finger MYND domain-containing protein 11 isoform X1. (617 aa)
MID2Probable E3 ubiquitin-protein ligase MID2 isoform X4. (770 aa)
RNF31E3 ubiquitin-protein ligase RNF31 isoform X1. (1094 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
DDX1ATP-dependent RNA helicase DDX1. (740 aa)
WDR83WD repeat domain-containing protein 83. (315 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1. (693 aa)
BTNL9Butyrophilin-like protein 9. (540 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1. (191 aa)
ZFAND6AN1-type zinc finger protein 6. (208 aa)
S100A13Protein S100-A13; Belongs to the S-100 family. (98 aa)
SHARPINSharpin isoform X1. (484 aa)
S100A4Protein S100; Belongs to the S-100 family. (101 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
NLRX1NLR family member X1 isoform X1. (973 aa)
LOC111165753NACHT, LRR and PYD domains-containing protein 12 isoform X2. (1105 aa)
CACTINCactin. (755 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1027 aa)
CUNH1orf106Uncharacterized protein C1orf106 homolog. (540 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (717 aa)
LOC111168424Zinc finger protein RFP. (513 aa)
S100A12LOW QUALITY PROTEIN: protein S100-A12; Belongs to the S-100 family. (136 aa)
ASH1LHistone-lysine N-methyltransferase ASH1L isoform X1. (2964 aa)
AKAP13A-kinase anchor protein 13 isoform X5. (1430 aa)
TRIM38E3 ubiquitin-protein ligase TRIM38. (461 aa)
CTNNB1Catenin beta-1. (781 aa)
TRIM68E3 ubiquitin-protein ligase TRIM68 isoform X1. (533 aa)
LOC111169218Tripartite motif-containing protein 6-like. (487 aa)
SQSTM1Sequestosome-1. (440 aa)
EDA2RTumor necrosis factor receptor superfamily member 27 isoform X1. (364 aa)
TMEM101Transmembrane protein 101. (257 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (284 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14 isoform X1. (961 aa)
TMEM106ATransmembrane protein 106A isoform X1. (293 aa)
AGPAT41-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1. (835 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (725 aa)
TRIM21E3 ubiquitin-protein ligase TRIM21. (469 aa)
EDAectodysplasin-A isoform X1; Belongs to the tumor necrosis factor family. (391 aa)
NLRP6LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6. (876 aa)
CARD11Caspase recruitment domain-containing protein 11 isoform X1. (1154 aa)
DHX15pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15. (795 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (547 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (518 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (486 aa)
LOC111171742Ubiquitin-conjugating enzyme E2 variant 1. (147 aa)
CCDC22Coiled-coil domain-containing protein 22 isoform X1. (627 aa)
OTUD7BOTU domain-containing protein 7B isoform X1. (874 aa)
TRIM8Probable E3 ubiquitin-protein ligase TRIM8. (510 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (412 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (607 aa)
PIDD1P53-induced death domain-containing protein 1 isoform X1. (971 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
PPM1AProtein phosphatase 1A. (382 aa)
LOC111170681E3 ubiquitin-protein ligase TRIM39. (488 aa)
TRIML2Probable E3 ubiquitin-protein ligase TRIML2. (438 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (288 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (882 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X1. (531 aa)
TRIM59Tripartite motif-containing protein 59. (401 aa)
HTR2B5-hydroxytryptamine receptor 2B. (490 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
PRKCEProtein kinase C. (746 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
TNFRSF19Tumor necrosis factor receptor superfamily member 19 isoform X1. (425 aa)
PPM1MProtein phosphatase 1M isoform X1. (461 aa)
TRIML1Probable E3 ubiquitin-protein ligase TRIML1. (468 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
LURAP1LLeucine rich adaptor protein 1-like. (226 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
PPM1BProtein phosphatase 1B isoform X1. (479 aa)
RHOATransforming protein RhoA. (193 aa)
TRIM13E3 ubiquitin-protein ligase TRIM13. (407 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
LTFLactotransferrin; Belongs to the transferrin family. (710 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
LTBRTumor necrosis factor receptor superfamily member 3. (421 aa)
LOC111176754C-type lectin domain family 7 member A-like isoform X1. (244 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32 isoform X1. (699 aa)
TLE1Transducin-like enhancer protein 1 isoform X3. (843 aa)
RORANuclear receptor ROR-alpha isoform X1. (523 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
TRIM62E3 ubiquitin-protein ligase TRIM62 isoform X1. (475 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
LOC111177912OTU domain-containing protein 7A. (900 aa)
LURAP1Leucine rich adaptor protein 1. (239 aa)
CARD9Caspase recruitment domain-containing protein 9 isoform X1. (539 aa)
ROR1Inactive tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
OPTNOptineurin isoform X1. (567 aa)
TRAF1TNF receptor-associated factor. (415 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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