(40 nodes) Negative regulation of I-kappaB kinase/NF-kappaB signaling network (Delphinapterus leucas)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DAB2IP	Disabled homolog 2-interacting protein isoform X1. (1193 aa)
	PPM1B	Protein phosphatase 1B isoform X1. (479 aa)
	ZC3H12A	Endoribonuclease ZC3H12A. (583 aa)
	HDAC1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
	PPM1M	Protein phosphatase 1M isoform X1. (461 aa)
	TRIM59	Tripartite motif-containing protein 59. (401 aa)
	TANK	TRAF family member-associated NF-kappa-B activator isoform X1. (531 aa)
	LOC111170681	E3 ubiquitin-protein ligase TRIM39. (488 aa)
	PPM1A	Protein phosphatase 1A. (382 aa)
	RHOH	Rho-related GTP-binding protein RhoH. (191 aa)
	OTUD7B	OTU domain-containing protein 7B isoform X1. (874 aa)
	CCDC22	Coiled-coil domain-containing protein 22 isoform X1. (627 aa)
	CASP8	Caspase-8; Belongs to the peptidase C14A family. (486 aa)
	STAT1	Signal transducer and activator of transcription. (749 aa)
	CASP10	Caspase-10; Belongs to the peptidase C14A family. (518 aa)
	NLRP6	LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6. (876 aa)
	ASH1L	Histone-lysine N-methyltransferase ASH1L isoform X1. (2964 aa)
	CACTIN	Cactin. (755 aa)
	LOC111165753	NACHT, LRR and PYD domains-containing protein 12 isoform X2. (1105 aa)
	NLRX1	NLR family member X1 isoform X1. (973 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (785 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (613 aa)
	ZMYND11	Zinc finger MYND domain-containing protein 11 isoform X1. (617 aa)
	NR1H4	Bile acid receptor isoform X1. (486 aa)
	NLRC3	NLR family CARD domain-containing protein 3 isoform X1. (1066 aa)
	TNIP3	TNFAIP3-interacting protein 3 isoform X1. (375 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
	TNIP1	TNFAIP3-interacting protein 1 isoform X1. (634 aa)
	MAPKBP1	Mitogen-activated protein kinase-binding protein 1 isoform X1. (1510 aa)
	PPM1N	Probable protein phosphatase 1N isoform X1. (490 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (687 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD. (195 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (845 aa)
	RIOK3	Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (294 aa)
	ABL1	Tyrosine-protein kinase. (1148 aa)
	LOC111177912	OTU domain-containing protein 7A. (900 aa)
	RORA	Nuclear receptor ROR-alpha isoform X1. (523 aa)
	TLE1	Transducin-like enhancer protein 1 isoform X3. (843 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CACTIN	LOC111170681	A0A2Y9M6L3	A0A2Y9MXG3	Cactin.	E3 ubiquitin-protein ligase TRIM39.	0.628
CASP10	CASP8	A0A2Y9MLF7	A0A2Y9MQ94	Caspase-10; Belongs to the peptidase C14A family.	Caspase-8; Belongs to the peptidase C14A family.	0.974
CASP10	PYCARD	A0A2Y9MLF7	A0A2Y9PAE2	Caspase-10; Belongs to the peptidase C14A family.	Apoptosis-associated speck-like protein containing a CARD.	0.649
CASP10	RIPK1	A0A2Y9MLF7	A0A2Y9PAG9	Caspase-10; Belongs to the peptidase C14A family.	Receptor-interacting serine/threonine-protein kinase 1 isoform X1.	0.888
CASP8	CASP10	A0A2Y9MQ94	A0A2Y9MLF7	Caspase-8; Belongs to the peptidase C14A family.	Caspase-10; Belongs to the peptidase C14A family.	0.974
CASP8	ESR1	A0A2Y9MQ94	A0A2Y9M1Z4	Caspase-8; Belongs to the peptidase C14A family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.518
CASP8	PYCARD	A0A2Y9MQ94	A0A2Y9PAE2	Caspase-8; Belongs to the peptidase C14A family.	Apoptosis-associated speck-like protein containing a CARD.	0.974
CASP8	RIPK1	A0A2Y9MQ94	A0A2Y9PAG9	Caspase-8; Belongs to the peptidase C14A family.	Receptor-interacting serine/threonine-protein kinase 1 isoform X1.	0.998
CASP8	STAT1	A0A2Y9MQ94	A0A2Y9MPV2	Caspase-8; Belongs to the peptidase C14A family.	Signal transducer and activator of transcription.	0.479
ESR1	CASP8	A0A2Y9M1Z4	A0A2Y9MQ94	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Caspase-8; Belongs to the peptidase C14A family.	0.518
ESR1	HDAC1	A0A2Y9M1Z4	A0A2Y9N7S9	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.734
ESR1	SIRT1	A0A2Y9M1Z4	A0A2Y9PKW1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.473
ESR1	STAT1	A0A2Y9M1Z4	A0A2Y9MPV2	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Signal transducer and activator of transcription.	0.604
HDAC1	ESR1	A0A2Y9N7S9	A0A2Y9M1Z4	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.734
HDAC1	SIRT1	A0A2Y9N7S9	A0A2Y9PKW1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.786
HDAC1	STAT1	A0A2Y9N7S9	A0A2Y9MPV2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Signal transducer and activator of transcription.	0.737
HDAC1	TLE1	A0A2Y9N7S9	A0A2Y9NIP4	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Transducin-like enhancer protein 1 isoform X3.	0.878
LOC111165753	NLRP6	A0A2Y9M4W7	A0A2Y9MIX3	NACHT, LRR and PYD domains-containing protein 12 isoform X2.	LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6.	0.438
LOC111165753	PYCARD	A0A2Y9M4W7	A0A2Y9PAE2	NACHT, LRR and PYD domains-containing protein 12 isoform X2.	Apoptosis-associated speck-like protein containing a CARD.	0.638
LOC111170681	CACTIN	A0A2Y9MXG3	A0A2Y9M6L3	E3 ubiquitin-protein ligase TRIM39.	Cactin.	0.628