STRINGSTRING
SIK1 SIK1 ID2 ID2 FBXL6 FBXL6 PDE6B PDE6B FBXL12 FBXL12 USP2 USP2 CRTC1 CRTC1 NR2F6 NR2F6 PER2 PER2 BHLHE40 BHLHE40 PPP1CB PPP1CB FBXL22 FBXL22 FBXL3 FBXL3 OPN5 OPN5 PML PML FBXL8 FBXL8 ATOH7 ATOH7 PPP1CA PPP1CA LOC111182465 LOC111182465 LOC111182472 LOC111182472 LOC111183699 LOC111183699 CRY2 CRY2 LOC111183698 LOC111183698 FBXL17 FBXL17 PER1 PER1 PPP1CC PPP1CC PER3 PER3 CRY1 CRY1 TP53 TP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIK1Serine/threonine-protein kinase SIK1. (784 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
FBXL6F-box/LRR-repeat protein 6 isoform X1. (541 aa)
PDE6BPhosphodiesterase. (856 aa)
FBXL12F-box/LRR-repeat protein 12 isoform X1. (326 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (603 aa)
CRTC1CREB-regulated transcription coactivator 1 isoform X1. (655 aa)
NR2F6Nuclear receptor subfamily 2 group F member 6. (413 aa)
PER2Period circadian protein homolog 2. (1294 aa)
BHLHE40Class E basic helix-loop-helix protein 40. (412 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
FBXL22F-box and leucine-rich protein 22. (226 aa)
FBXL3F-box/LRR-repeat protein 3. (429 aa)
OPN5Opsin-5; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PMLProtein PML isoform X1. (861 aa)
FBXL8F-box/LRR-repeat protein 8 isoform X1. (374 aa)
ATOH7Protein atonal homolog 7. (152 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LOC111182465F-box/LRR-repeat protein 21-like. (461 aa)
LOC111182472F-box/LRR-repeat protein 21. (462 aa)
LOC111183699RNA-binding protein 4 isoform X1. (363 aa)
CRY2Cryptochrome-2. (588 aa)
LOC111183698RNA-binding protein 4B isoform X1. (369 aa)
FBXL17F-box/LRR-repeat protein 17 isoform X1. (701 aa)
PER1Period circadian protein homolog 1 isoform X1. (1267 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PER3Period circadian protein homolog 3 isoform X1. (1151 aa)
CRY1Cryptochrome-1 isoform X1. (587 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (387 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.