STRINGSTRING
CCL19 CCL19 AGT AGT AJUBA AJUBA MAP3K7 MAP3K7 TRIB2 TRIB2 NOD2 NOD2 CBS CBS TPD52L1 TPD52L1 TRIB1 TRIB1 PIK3CG PIK3CG INSR INSR LOC111165935 LOC111165935 CDK5RAP3 CDK5RAP3 LOC111166741 LOC111166741 BMP2 BMP2 GBA GBA LYN LYN ERBB2 ERBB2 SORL1 SORL1 TGFA TGFA PTPRC PTPRC MAP3K5 MAP3K5 CDK12 CDK12 NTRK3 NTRK3 PDGFA PDGFA KIT KIT SMPD1 SMPD1 DRD4 DRD4 CD40 CD40 MAP3K4 MAP3K4 PDGFD PDGFD SYK SYK HRAS HRAS IRAK1 IRAK1 SPRY3 SPRY3 AGER AGER LOC111171273 LOC111171273 RGS14 RGS14 FZD5 FZD5 CAV3 CAV3 MAP3K13 MAP3K13 BMP4 BMP4 SFRP1 SFRP1 MAP3K12 MAP3K12 ADRA2A ADRA2A DUSP19 DUSP19 LRRK2 LRRK2 EPHA4 EPHA4 HTR2B HTR2B DUSP7 DUSP7 ADAM8 ADAM8 WNT5A WNT5A SOS1 SOS1 FGFR1 FGFR1 TNFSF11 TNFSF11 IRAK3 IRAK3 FLT1 FLT1 PRKCD PRKCD DVL3 DVL3 ADAM9 ADAM9 PDCD10 PDCD10 HYAL2 HYAL2 MST1R MST1R PTPN6 PTPN6 TRAF2 TRAF2 SPRY2 SPRY2 DUSP16 DUSP16 PDGFC PDGFC PSEN1 PSEN1 EZH2 EZH2 DAB2IP DAB2IP ROBO1 ROBO1 DUSP10 DUSP10 CAV1 CAV1 TSG101 TSG101 IL34 IL34 FGD2 FGD2 TNFRSF11A TNFRSF11A TGFB1 TGFB1 TRAF6 TRAF6 ERN2 ERN2 NUP62 NUP62 RASGRP1 RASGRP1 ERN1 ERN1 MAP3K10 MAP3K10 DTNBP1 DTNBP1 EDN1 EDN1 LOC111182867 LOC111182867 MAP2K6 MAP2K6 HGS HGS TMEM130 TMEM130 THBS1 THBS1 MAP4K2 MAP4K2 SPRY4 SPRY4 FGF1 FGF1 LAX1 LAX1 RPS3 RPS3 TRIB3 TRIB3 MAP3K11 MAP3K11 PAK1 PAK1 NOX4 NOX4 KSR1 KSR1 FZD4 FZD4 AXIN1 AXIN1 INPP5K INPP5K HMGCR HMGCR PDGFB PDGFB EGFR EGFR P2RX7 P2RX7 SPRY1 SPRY1 SH2B3 SH2B3 DUSP1 DUSP1 FGF18 FGF18 DVL2 DVL2 NF1 NF1 TAOK3 TAOK3 FZD10 FZD10 PIK3R5 PIK3R5 PIK3R6 PIK3R6 EPGN EPGN BMP7 BMP7 PTPN1 PTPN1 PAQR3 PAQR3 SFRP2 SFRP2 TNF TNF IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCL19C-C motif chemokine. (159 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
AJUBALIM domain-containing protein ajuba isoform X1. (557 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TRIB2Tribbles homolog 2. (343 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (562 aa)
TPD52L1Tumor protein D53 isoform X1. (209 aa)
TRIB1Tribbles homolog 1. (372 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1102 aa)
INSRTyrosine-protein kinase receptor. (1392 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
CDK5RAP3CDK5 regulatory subunit-associated protein 3 isoform X1. (544 aa)
LOC111166741SAM and SH3 domain-containing protein 1 isoform X1. (1513 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GBAGlucosylceramidase. (585 aa)
LYNTyrosine-protein kinase. (518 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
SORL1Sortilin-related receptor isoform X1. (2211 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5 isoform X1. (1366 aa)
CDK12Cyclin-dependent kinase 12 isoform X1. (1490 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (623 aa)
DRD4D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (521 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (284 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4 isoform X1. (1601 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (402 aa)
SYKTyrosine-protein kinase. (626 aa)
HRASGTPase HRas isoform X1. (189 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (725 aa)
SPRY3Protein sprouty homolog 3. (288 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
LOC111171273tenascin-X-like. (151 aa)
RGS14Regulator of G-protein signaling 14 isoform X1. (604 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (929 aa)
ADRA2Aalpha-2A adrenergic receptor. (465 aa)
DUSP19Dual specificity protein phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (226 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2 isoform X1. (2527 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
HTR2B5-hydroxytryptamine receptor 2B. (490 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8 isoform X1. (838 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
IRAK3Interleukin-1 receptor-associated kinase 3 isoform X2. (674 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X3. (731 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9 isoform X1. (841 aa)
PDCD10Programmed cell death protein 10. (212 aa)
HYAL2Hyaluronidase. (476 aa)
MST1RMacrophage-stimulating protein receptor isoform X1. (1406 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
SPRY2Protein sprouty homolog 2. (315 aa)
DUSP16Dual specificity protein phosphatase 16. (660 aa)
PDGFCPlatelet-derived growth factor C isoform X2. (380 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (747 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1193 aa)
ROBO1Roundabout homolog 1 isoform X1. (1685 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
TSG101Tumor susceptibility gene 101 protein isoform X1. (429 aa)
IL34Interleukin-34. (235 aa)
FGD2FYVE, RhoGEF and PH domain-containing protein 2 isoform X1. (732 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A isoform X1. (551 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
ERN2Serine/threonine-protein kinase/endoribonuclease IRE2. (927 aa)
NUP62Nuclear pore glycoprotein p62. (516 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (870 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (975 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (948 aa)
DTNBP1Dysbindin isoform X1. (341 aa)
EDN1Endothelin-1. (202 aa)
LOC111182867CMRF35-like molecule 8 isoform X1. (313 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6 isoform X1; Belongs to the protein kinase superfamily. (368 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
TMEM130Transmembrane protein 130 isoform X1. (435 aa)
THBS1Thrombospondin-1. (1170 aa)
MAP4K2Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa)
SPRY4Protein sprouty homolog 4. (299 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
LAX1LOW QUALITY PROTEIN: lymphocyte transmembrane adapter 1. (430 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (357 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (858 aa)
PAK1Non-specific serine/threonine protein kinase. (543 aa)
NOX4NADPH oxidase 4. (530 aa)
KSR1Kinase suppressor of Ras 1 isoform X1. (905 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
AXIN1Axin-1 isoform X1. (866 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (476 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
SPRY1Protein sprouty homolog 1. (319 aa)
SH2B3SH2B adapter protein 3 isoform X1. (618 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (736 aa)
NF1Neurofibromin isoform X1. (2873 aa)
TAOK3Serine/threonine-protein kinase TAO3. (898 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (871 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6 isoform X1. (881 aa)
EPGNEpigen. (153 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (451 aa)
PAQR3Progestin and adipoQ receptor family member 3 isoform X1. (311 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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