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FGF8 FGF8 PRKCI PRKCI ADAM8 ADAM8 ERBB3 ERBB3 SIX1 SIX1 PIK3CA PIK3CA FAIM2 FAIM2 HIF1A HIF1A MAP3K12 MAP3K12 BOK BOK NR4A2 NR4A2 CITED1 CITED1 SIX4 SIX4 GRN GRN SEMA3E SEMA3E PPARGC1A PPARGC1A KDR KDR FGF20 FGF20 NTF3 NTF3 AGAP2 AGAP2 EN2 EN2 KRAS KRAS CHL1 CHL1 STXBP1 STXBP1 POU4F1 POU4F1 SLC30A10 SLC30A10 BARHL1 BARHL1 MSH2 MSH2 LGMN LGMN MECP2 MECP2 BHLHB9 BHLHB9 HRAS HRAS AGPAT4 AGPAT4 SNCB SNCB CX3CR1 CX3CR1 ZPR1 ZPR1 PLXND1 PLXND1 CRLF1 CRLF1 HYOU1 HYOU1 NES NES NTRK1 NTRK1 TOX3 TOX3 GBA GBA HDGF HDGF IL27RA IL27RA LOC111165935 LOC111165935 NRBP2 NRBP2 NFATC4 NFATC4 ISL1 ISL1 GRIK2 GRIK2 PINK1 PINK1 PLA2G3 PLA2G3 LIG4 LIG4 PTPRZ1 PTPRZ1 HIPK2 HIPK2 BRAF BRAF TFAP2B TFAP2B XRCC2 XRCC2 FOXB1 FOXB1 THAP11 THAP11 SYNGAP1 SYNGAP1 AARS AARS GFRAL GFRAL RETREG1 RETREG1 AXL AXL PRKCG PRKCG WFS1 WFS1 TFAP2D TFAP2D MAG MAG TYRO3 TYRO3 BCL2 BCL2 ROCK1 ROCK1 NGF NGF FZD9 FZD9 OXR1 OXR1 NTF4 NTF4 TMBIM7P TMBIM7P FOXQ1 FOXQ1 HDGFL1 HDGFL1 BIRC5 BIRC5 CNTF CNTF UNC5B UNC5B CLN3 CLN3 AMBRA1 AMBRA1 CLCF1 CLCF1 CORO1A CORO1A CCND1 CCND1 MEF2C MEF2C RASA1 RASA1 EN1 EN1 VSTM2L VSTM2L MAP2K4 MAP2K4 NDNF NDNF GABRB2 GABRB2 NEFL NEFL LOC111185731 LOC111185731 F2R F2R IL6ST IL6ST GABRA5 GABRA5 DNAJC5B DNAJC5B CEBPB CEBPB GDNF GDNF VPS54 VPS54 DNAJC5 DNAJC5 ADNP ADNP KDM2B KDM2B PARK7 PARK7 DRAXIN DRAXIN RHOA RHOA JUN JUN ALKBH1 ALKBH1 DLX1 DLX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8 isoform X1. (838 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
SIX1Homeobox protein SIX1. (284 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FAIM2Protein lifeguard 2; Belongs to the BI1 family. (316 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (929 aa)
BOKBcl-2-related ovarian killer protein. (213 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2 isoform X1. (598 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X1. (359 aa)
SIX4Homeobox protein SIX4 isoform X1. (790 aa)
GRNGranulins isoform X1. (587 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (265 aa)
AGAP2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1. (1192 aa)
EN2Homeobox protein engrailed-like. (328 aa)
KRASGTPase KRas. (188 aa)
CHL1Neural cell adhesion molecule L1-like protein isoform X1. (1225 aa)
STXBP1Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
POU4F1POU domain protein. (422 aa)
SLC30A10Zinc transporter 10. (485 aa)
BARHL1barH-like 1 homeobox protein. (327 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
LGMNLegumain. (433 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
BHLHB9Protein BHLHb9. (564 aa)
HRASGTPase HRas isoform X1. (189 aa)
AGPAT41-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1. (835 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (134 aa)
CX3CR1CX3C chemokine receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
ZPR1Zinc finger protein ZPR1. (459 aa)
PLXND1plexin-D1. (1927 aa)
CRLF1Cytokine receptor-like factor 1. (446 aa)
HYOU1Hypoxia up-regulated protein 1 isoform X1. (998 aa)
NESNestin; Belongs to the intermediate filament family. (1570 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
TOX3TOX high mobility group box family member 3 isoform X1. (570 aa)
GBAGlucosylceramidase. (585 aa)
HDGFHepatoma-derived growth factor. (237 aa)
IL27RAInterleukin-27 receptor subunit alpha isoform X1. (656 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
NRBP2Nuclear receptor-binding protein 2 isoform X1. (572 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
GRIK2Glutamate receptor ionotropic, kainate 2 isoform X2. (908 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial isoform X1. (584 aa)
PLA2G3Group 3 secretory phospholipase A2 isoform X1. (516 aa)
LIG4DNA ligase. (911 aa)
PTPRZ1Receptor-type tyrosine-protein phosphatase zeta isoform X1. (2321 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1248 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
TFAP2BTranscription factor AP-2-beta isoform X1. (467 aa)
XRCC2DNA repair protein XRCC2. (280 aa)
FOXB1Forkhead box protein B1. (325 aa)
THAP11THAP domain-containing protein 11. (309 aa)
SYNGAP1ras/Rap GTPase-activating protein SynGAP isoform X1. (1345 aa)
AARSalanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
GFRALLOW QUALITY PROTEIN: GDNF family receptor alpha-like. (397 aa)
RETREG1Reticulophagy regulator 1 isoform X1. (500 aa)
AXLLOW QUALITY PROTEIN: tyrosine-protein kinase receptor UFO. (887 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
WFS1Wolframin. (889 aa)
TFAP2DTranscription factor AP-2-delta. (452 aa)
MAGMyelin-associated glycoprotein isoform X1. (850 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3 isoform X3. (896 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa)
OXR1Oxidation resistance protein 1 isoform X3. (873 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (247 aa)
TMBIM7PLOW QUALITY PROTEIN: protein lifeguard 2; Belongs to the BI1 family. (310 aa)
FOXQ1LOW QUALITY PROTEIN: forkhead box protein Q1. (375 aa)
HDGFL1Hepatoma-derived growth factor-like protein 1. (233 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
CNTFCiliary neurotrophic factor. (200 aa)
UNC5BNetrin receptor UNC5B isoform X1. (945 aa)
CLN3Battenin. (436 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1295 aa)
CLCF1Cardiotrophin-like cytokine factor 1 isoform X1. (281 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X6. (483 aa)
RASA1Ras GTPase-activating protein 1 isoform X1. (1040 aa)
EN1Homeobox protein engrailed-like. (406 aa)
VSTM2LV-set and transmembrane domain-containing protein 2-like protein. (205 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X4; Belongs to the protein kinase superfamily. (410 aa)
NDNFProtein NDNF. (568 aa)
GABRB2Gamma-aminobutyric acid receptor subunit beta-2 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
NEFLNeurofilament light polypeptide; Belongs to the intermediate filament family. (554 aa)
LOC111185731C-C motif chemokine. (99 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
GABRA5Gamma-aminobutyric acid receptor subunit alpha-5 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (576 aa)
DNAJC5BdnaJ homolog subfamily C member 5B. (199 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
GDNFGlial cell line-derived neurotrophic factor. (185 aa)
VPS54Vacuolar protein sorting-associated protein 54 isoform X1. (1001 aa)
DNAJC5dnaJ homolog subfamily C member 5. (198 aa)
ADNPActivity-dependent neuroprotector homeobox protein. (1101 aa)
KDM2BLysine-specific demethylase 2B isoform X1. (1324 aa)
PARK7Protein DJ-1. (189 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (350 aa)
RHOATransforming protein RhoA. (193 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
ALKBH1Nucleic acid dioxygenase ALKBH1. (381 aa)
DLX1Homeobox protein DLX-1 isoform X1. (255 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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