STRINGSTRING
PIK3IP1 PIK3IP1 CCL19 CCL19 FGR FGR EPHA8 EPHA8 SOCS1 SOCS1 SOCS2 SOCS2 CCL21 CCL21 RBL2 RBL2 NOD2 NOD2 TEK TEK FGFR3 FGFR3 PIP4K2B PIP4K2B PIK3R2 PIK3R2 LYN LYN SOCS7 SOCS7 NRBF2 NRBF2 PIK3R4 PIK3R4 PDGFRA PDGFRA SOCS4 SOCS4 RUBCN RUBCN SOCS5 SOCS5 FLT1 FLT1 ATG14 ATG14 PIK3R3 PIK3R3 LOC111175110 LOC111175110 CISH CISH PIP4K2C PIP4K2C VAV2 VAV2 PIP4K2A PIP4K2A DAB2IP DAB2IP WDR91 WDR91 VAV3 VAV3 TGFB1 TGFB1 CD19 CD19 SOCS6 SOCS6 CD81 CD81 SOCS3 SOCS3 PDGFRB PDGFRB AMBRA1 AMBRA1 PPP2R5A PPP2R5A DGKZ DGKZ RBL1 RBL1 F2 F2 SLA2 SLA2 PDGFB PDGFB EEF1A2 EEF1A2 PTK2B PTK2B WDR81 WDR81 PIK3R1 PIK3R1 PIK3R5 PIK3R5 PIK3R6 PIK3R6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3IP1Phosphoinositide-3-kinase-interacting protein 1 isoform X1. (264 aa)
CCL19C-C motif chemokine. (159 aa)
FGRTyrosine-protein kinase. (526 aa)
EPHA8Ephrin type-A receptor 8. (1005 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
CCL21C-C motif chemokine 21 isoform X1. (131 aa)
RBL2Retinoblastoma-like protein 2. (1083 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
LYNTyrosine-protein kinase. (518 aa)
SOCS7Suppressor of cytokine signaling 7 isoform X1. (641 aa)
NRBF2Nuclear receptor-binding factor 2 isoform X1. (288 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
RUBCNRun domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1. (1007 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
ATG14Beclin 1-associated autophagy-related key regulator. (492 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (461 aa)
LOC111175110Nuclear receptor-binding factor 2-like. (226 aa)
CISHCytokine-inducible SH2-containing protein isoform X1. (254 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (421 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1. (461 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1193 aa)
WDR91WD repeat-containing protein 91 isoform X1. (746 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CD19B-lymphocyte antigen CD19 isoform X1. (570 aa)
SOCS6Suppressor of cytokine signaling 6. (535 aa)
CD81Tetraspanin. (236 aa)
SOCS3Suppressor of cytokine signaling 3. (237 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1295 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (487 aa)
DGKZDiacylglycerol kinase. (1210 aa)
RBL1Retinoblastoma-like protein 1 isoform X2. (1073 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
SLA2Src-like-adapter 2 isoform X1. (276 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
WDR81WD repeat-containing protein 81. (1944 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5 isoform X1. (871 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6 isoform X1. (881 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.