(14 nodes) Response to leptin network (Delphinapterus leucas)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	INHBB	Inhibin beta B chain. (407 aa)
	LRP2	Low-density lipoprotein receptor-related protein 2. (4838 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (721 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (613 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	EBI3	Interleukin-27 subunit beta isoform X1. (258 aa)
	PID1	PTB-containing, cubilin and LRP1-interacting protein isoform X1. (268 aa)
	Ob	Leptin isoform X1. (167 aa)
	CCND1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
	LEPR	Leptin receptor isoform X1. (917 aa)
	UGCG	Ceramide glucosyltransferase. (394 aa)
	BBS4	Bardet-Biedl syndrome 4 protein isoform X1. (528 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BBS2	BBS4	A0A2Y9LQL9	A0A2Y9NKP2	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 4 protein isoform X1.	0.997
BBS4	BBS2	A0A2Y9NKP2	A0A2Y9LQL9	Bardet-Biedl syndrome 4 protein isoform X1.	Bardet-Biedl syndrome 2 protein homolog.	0.997
CCND1	LEP	A0A2Y9PNM2	A0A2Y9PHF5	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.438
CCND1	Ob	A0A2Y9PNM2	G8DLG4	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Leptin isoform X1.	0.438
CCND1	SIRT1	A0A2Y9PNM2	A0A2Y9PKW1	G1/S-specific cyclin-D1; Belongs to the cyclin family.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.606
CCND1	STAT3	A0A2Y9PNM2	A0A2Y9LX05	G1/S-specific cyclin-D1; Belongs to the cyclin family.	Signal transducer and activator of transcription.	0.829
LEP	CCND1	A0A2Y9PHF5	A0A2Y9PNM2	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.438
LEP	LEPR	A0A2Y9PHF5	A0A2Y9NSA2	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Leptin receptor isoform X1.	0.896
LEP	SIRT1	A0A2Y9PHF5	A0A2Y9PKW1	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.435
LEP	STAT3	A0A2Y9PHF5	A0A2Y9LX05	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	Signal transducer and activator of transcription.	0.728
LEPR	LEP	A0A2Y9NSA2	A0A2Y9PHF5	Leptin receptor isoform X1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.896
LEPR	Ob	A0A2Y9NSA2	G8DLG4	Leptin receptor isoform X1.	Leptin isoform X1.	0.989
LEPR	STAT3	A0A2Y9NSA2	A0A2Y9LX05	Leptin receptor isoform X1.	Signal transducer and activator of transcription.	0.662
Ob	CCND1	G8DLG4	A0A2Y9PNM2	Leptin isoform X1.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.438
Ob	LEPR	G8DLG4	A0A2Y9NSA2	Leptin isoform X1.	Leptin receptor isoform X1.	0.989
Ob	SIRT1	G8DLG4	A0A2Y9PKW1	Leptin isoform X1.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.435
Ob	STAT3	G8DLG4	A0A2Y9LX05	Leptin isoform X1.	Signal transducer and activator of transcription.	0.728
SIRT1	CCND1	A0A2Y9PKW1	A0A2Y9PNM2	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.606
SIRT1	LEP	A0A2Y9PKW1	A0A2Y9PHF5	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.435
SIRT1	Ob	A0A2Y9PKW1	G8DLG4	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	Leptin isoform X1.	0.435