STRINGSTRING
SFN SFN KDF1 KDF1 GRHL1 GRHL1 HEY2 HEY2 KRT36 KRT36 MED1 MED1 PTCH1 PTCH1 KEAP1 KEAP1 DLL1 DLL1 NCOA3 NCOA3 ETV4 ETV4 KLF7 KLF7 NUMA1 NUMA1 BMP4 BMP4 SGPP1 SGPP1 HES1 HES1 VDR VDR TP63 TP63 MYCL MYCL ZFP36L1 ZFP36L1 PRKCH PRKCH PTCH2 PTCH2 ZBED2 ZBED2 LOC111177240 LOC111177240 NOTCH1 NOTCH1 EZH2 EZH2 ATOH1 ATOH1 ZFP36 ZFP36 ROCK1 ROCK1 LOC111182462 LOC111182462 HOXA7 HOXA7 LOC111183465 LOC111183465 MAFG MAFG SRSF6 SRSF6 CD109 CD109 SFRP4 SFRP4 LOC111185769 LOC111185769 HES5 HES5 ERRFI1 ERRFI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
GRHL1Grainyhead-like protein 1 homolog. (630 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
KRT36Keratin, type I cuticular Ha6; Belongs to the intermediate filament family. (459 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
PTCH1Protein patched homolog 1 isoform X1. (1447 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (799 aa)
NCOA3Nuclear receptor coactivator. (1406 aa)
ETV4ETS translocation variant 4 isoform X2. (482 aa)
KLF7Krueppel-like factor 7 isoform X1. (303 aa)
NUMA1Nuclear mitotic apparatus protein 1 isoform X1. (2125 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (445 aa)
HES1Transcription factor HES-1. (280 aa)
VDRVitamin D3 receptor isoform X1. (503 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
MYCLProtein L-Myc. (394 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
PTCH2Protein patched homolog 2 isoform X1. (1234 aa)
ZBED2Zinc finger BED domain-containing protein 2. (201 aa)
LOC111177240LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 6-like. (346 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (747 aa)
ATOH1Protein atonal homolog 1. (352 aa)
ZFP36mRNA decay activator protein ZFP36. (325 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
LOC111182462Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
HOXA7Homeobox protein Hox-A7. (233 aa)
LOC111183465Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
MAFGTranscription factor MafG. (162 aa)
SRSF6Serine/arginine-rich splicing factor 6 isoform X1. (345 aa)
CD109CD109 antigen isoform X1. (1440 aa)
SFRP4Secreted frizzled-related protein 4. (346 aa)
LOC111185769Arachidonate 15-lipoxygenase B-like. (677 aa)
HES5Transcription factor HES-5 isoform X1. (205 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (459 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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