(65 nodes) Negative regulation of myeloid cell differentiation network (Delphinapterus leucas)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LRRC17	Leucine-rich repeat-containing protein 17 isoform X1. (440 aa)
	CTR9	RNA polymerase-associated protein CTR9 homolog isoform X1. (1214 aa)
	TRIB1	Tribbles homolog 1. (372 aa)
	GPR137B	Integral membrane protein GPR137B. (385 aa)
	SFRP1	Secreted frizzled-related protein 1. (308 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	C1QC	Complement C1q subcomponent subunit C. (245 aa)
	LOC111163731	C-C motif chemokine. (93 aa)
	INPP5D	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
	LOC111174848	Uncharacterized protein LOC111174848 isoform X1. (334 aa)
	GABPA	GA-binding protein alpha chain. (454 aa)
	TCTA	T-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (106 aa)
	ZFP36L1	mRNA decay activator protein ZFP36L1. (338 aa)
	GPR68	Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (314 aa)
	LTF	Lactotransferrin; Belongs to the transferrin family. (710 aa)
	ITPKB	Kinase; Belongs to the inositol phosphokinase (IPK) family. (941 aa)
	LEO1	RNA polymerase-associated protein LEO1 isoform X1. (672 aa)
	LOC111174846	Transmembrane protein 178A-like isoform X1. (177 aa)
	WDR61	WD repeat-containing protein 61 isoform X2. (305 aa)
	CUL4A	cullin-4A; Belongs to the cullin family. (761 aa)
	CLDN18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
	ZFPM1	Zinc finger protein ZFPM1 isoform X1. (1069 aa)
	LOC111177621	RNA polymerase-associated protein LEO1-like. (292 aa)
	RBM15	Putative RNA-binding protein 15. (962 aa)
	FBN1	Fibrillin-1 isoform X1. (2871 aa)
	MAFB	Transcription factor MafB. (323 aa)
	GPR137	Integral membrane protein GPR137 isoform X1. (395 aa)
	ZBTB46	Zinc finger and BTB domain-containing protein 46. (590 aa)
	PTK2B	Protein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
	MEIS1	Homeobox protein Meis1 isoform X1. (465 aa)
	NF1	Neurofibromin isoform X1. (2873 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	TOB2	Protein Tob2. (343 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
	FBXW7	F-box/WD repeat-containing protein 7 isoform X1. (707 aa)
	CDC73	Parafibromin. (531 aa)
	GPR171	Probable G-protein coupled receptor 171; Belongs to the G-protein coupled receptor 1 family. (319 aa)
	ZFP36	mRNA decay activator protein ZFP36. (325 aa)
	CDK6	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa)
	PRMT1	Protein arginine N-methyltransferase 1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
	HOXA9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
	HOXA5	Homeobox protein Hox-A5. (381 aa)
	PAF1	RNA polymerase II-associated factor 1 homolog isoform X1. (533 aa)
	MEIS2	Homeobox protein Meis2 isoform X1. (477 aa)
	PIAS3	E3 SUMO-protein ligase PIAS3 isoform X1. (628 aa)
	HOXA7	Homeobox protein Hox-A7. (233 aa)
	HSPA9	Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. (679 aa)
	RARA	Retinoic acid receptor alpha isoform X5. (584 aa)
	STAT5A	Signal transducer and activator of transcription. (818 aa)
	LOC111166483	Signal transducer and activator of transcription. (787 aa)
	APCS	LOW QUALITY PROTEIN: serum amyloid P-component. (139 aa)
	LYN	Tyrosine-protein kinase. (518 aa)
	FBXW9	F-box/WD repeat-containing protein 9 isoform X1. (461 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
	UBASH3B	Ubiquitin-associated and SH3 domain-containing protein B isoform X1. (649 aa)
	ZBTB16	Zinc finger and BTB domain-containing protein 16. (673 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (799 aa)
	FSTL3	Follistatin-related protein 3. (262 aa)
	CIB1	Calcium and integrin-binding protein 1. (191 aa)
	GPR55	G-protein coupled receptor 55 isoform X1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
	TNFAIP6	Tumor necrosis factor-inducible gene 6 protein isoform X1. (284 aa)
	LDB1	LIM domain-binding protein 1 isoform X3. (436 aa)
	HOXB8	Homeobox protein Hox-B8. (243 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APCS	C1QC	A0A2Y9LZA8	A0A2Y9LFX6	LOW QUALITY PROTEIN: serum amyloid P-component.	Complement C1q subcomponent subunit C.	0.413
C1QC	APCS	A0A2Y9LFX6	A0A2Y9LZA8	Complement C1q subcomponent subunit C.	LOW QUALITY PROTEIN: serum amyloid P-component.	0.413
CDC73	CTNNB1	A0A2Y9NYU2	A0A2Y9MAY9	Parafibromin.	Catenin beta-1.	0.780
CDC73	CTR9	A0A2Y9NYU2	A0A2Y9LRZ2	Parafibromin.	RNA polymerase-associated protein CTR9 homolog isoform X1.	0.999
CDC73	LEO1	A0A2Y9NYU2	A0A2Y9NJJ2	Parafibromin.	RNA polymerase-associated protein LEO1 isoform X1.	0.998
CDC73	LOC111177621	A0A2Y9NYU2	A0A2Y9NVL0	Parafibromin.	RNA polymerase-associated protein LEO1-like.	0.998
CDC73	PAF1	A0A2Y9NYU2	A0A2Y9P5P1	Parafibromin.	RNA polymerase II-associated factor 1 homolog isoform X1.	0.998
CDC73	WDR61	A0A2Y9NYU2	A0A2Y9NL84	Parafibromin.	WD repeat-containing protein 61 isoform X2.	0.998
CDK6	CTNNB1	A0A2Y9P3B0	A0A2Y9MAY9	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	Catenin beta-1.	0.542
CDK6	MYC	A0A2Y9P3B0	A0A2Y9LJB2	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.418
CTNNB1	CDC73	A0A2Y9MAY9	A0A2Y9NYU2	Catenin beta-1.	Parafibromin.	0.780
CTNNB1	CDK6	A0A2Y9MAY9	A0A2Y9P3B0	Catenin beta-1.	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	0.542
CTNNB1	DLL1	A0A2Y9MAY9	A0A2Y9MDM3	Catenin beta-1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.464
CTNNB1	FBXW7	A0A2Y9MAY9	A0A2Y9QCY1	Catenin beta-1.	F-box/WD repeat-containing protein 7 isoform X1.	0.475
CTNNB1	LEO1	A0A2Y9MAY9	A0A2Y9NJJ2	Catenin beta-1.	RNA polymerase-associated protein LEO1 isoform X1.	0.630
CTNNB1	LOC111177621	A0A2Y9MAY9	A0A2Y9NVL0	Catenin beta-1.	RNA polymerase-associated protein LEO1-like.	0.630
CTNNB1	MYC	A0A2Y9MAY9	A0A2Y9LJB2	Catenin beta-1.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.723
CTNNB1	PIK3R1	A0A2Y9MAY9	A0A2Y9Q8T5	Catenin beta-1.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.504
CTNNB1	SFRP1	A0A2Y9MAY9	A0A2Y9MX43	Catenin beta-1.	Secreted frizzled-related protein 1.	0.684
CTR9	CDC73	A0A2Y9LRZ2	A0A2Y9NYU2	RNA polymerase-associated protein CTR9 homolog isoform X1.	Parafibromin.	0.999