(46 nodes) Regulation of glial cell differentiation network (Delphinapterus leucas)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	DLX1	Homeobox protein DLX-1 isoform X1. (255 aa)
	LIF	Leukemia inhibitory factor. (202 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	OLIG2	Oligodendrocyte transcription factor 2. (323 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1 isoform X1. (385 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (613 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	ZNF365	Protein ZNF365. (408 aa)
	LDLR	Low-density lipoprotein receptor. (857 aa)
	RNF112	RING finger protein 112. (618 aa)
	GPR37L1	Prosaposin receptor GPR37L1. (464 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	GSX2	GS homeobox 2. (304 aa)
	EGR2	E3 SUMO-protein ligase EGR2 isoform X1. (422 aa)
	SERPINE2	Glia-derived nexin isoform X2; Belongs to the serpin family. (397 aa)
	ZNF488	Zinc finger protein 488. (324 aa)
	NKX6-2	Homeobox protein Nkx-6.2. (277 aa)
	OPALIN	Opalin isoform X1. (150 aa)
	DLX2	Homeobox protein DLX-2 isoform X1. (333 aa)
	HES1	Transcription factor HES-1. (280 aa)
	EPHA4	Ephrin type-A receptor 4 isoform X1. (986 aa)
	HDAC1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (393 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
	PTN	Pleiotrophin isoform X1. (168 aa)
	NOTCH1	Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
	DAAM2	Disheveled-associated activator of morphogenesis 2 isoform X1. (1097 aa)
	IL34	Interleukin-34. (235 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (294 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	TNFRSF21	Tumor necrosis factor receptor superfamily member 21 isoform X3. (701 aa)
	CLCF1	Cardiotrophin-like cytokine factor 1 isoform X1. (281 aa)
	SLC45A3	Solute carrier family 45 member 3. (553 aa)
	CNTN2	Contactin-2. (1043 aa)
	TENM4	Teneurin-4 isoform X1. (2864 aa)
	BIN1	Myc box-dependent-interacting protein 1 isoform X1. (594 aa)
	NKX2-2	Homeobox protein Nkx-2.2 isoform X1. (273 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
	DUSP15	Dual specificity protein phosphatase 15; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (235 aa)
	ASPA	Aspartoacylase. (313 aa)
	HES5	Transcription factor HES-5 isoform X1. (205 aa)
	IL6ST	Interleukin-6 receptor subunit beta. (918 aa)
	NF1	Neurofibromin isoform X1. (2873 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B. (454 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
	NKX6-1	Homeobox protein Nkx-6.1. (365 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPA	OLIG2	A0A2Y9Q0X9	A0A2Y9LG69	Aspartoacylase.	Oligodendrocyte transcription factor 2.	0.611
BMP2	CTNNB1	A0A2Y9LYV6	A0A2Y9MAY9	Bone morphogenetic protein 2.	Catenin beta-1.	0.524
BMP2	NOG	A0A2Y9LYV6	A0A2Y9LFG3	Bone morphogenetic protein 2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.991
BMP2	TGFB1	A0A2Y9LYV6	A0A2Y9P5D5	Bone morphogenetic protein 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.438
CLCF1	IL6ST	A0A2Y9PMM2	A0A2Y9Q671	Cardiotrophin-like cytokine factor 1 isoform X1.	Interleukin-6 receptor subunit beta.	0.937
CTNNB1	BMP2	A0A2Y9MAY9	A0A2Y9LYV6	Catenin beta-1.	Bone morphogenetic protein 2.	0.524
CTNNB1	DAAM2	A0A2Y9MAY9	A0A2Y9NX91	Catenin beta-1.	Disheveled-associated activator of morphogenesis 2 isoform X1.	0.469
CTNNB1	HDAC1	A0A2Y9MAY9	A0A2Y9N7S9	Catenin beta-1.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.739
CTNNB1	NOG	A0A2Y9MAY9	A0A2Y9LFG3	Catenin beta-1.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.515
CTNNB1	NOTCH1	A0A2Y9MAY9	A0A2Y9NWE7	Catenin beta-1.	Neurogenic locus notch homolog protein 1 isoform X1.	0.729
CTNNB1	SHH	A0A2Y9MAY9	A0A2Y9NDZ2	Catenin beta-1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.612
CTNNB1	TGFB1	A0A2Y9MAY9	A0A2Y9P5D5	Catenin beta-1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.692
DAAM2	CTNNB1	A0A2Y9NX91	A0A2Y9MAY9	Disheveled-associated activator of morphogenesis 2 isoform X1.	Catenin beta-1.	0.469
DLX1	DLX2	A0A2Y9N9G8	A0A2Y9MYA4	Homeobox protein DLX-1 isoform X1.	Homeobox protein DLX-2 isoform X1.	0.748
DLX1	HES5	A0A2Y9N9G8	A0A2Y9Q5N8	Homeobox protein DLX-1 isoform X1.	Transcription factor HES-5 isoform X1.	0.438
DLX2	DLX1	A0A2Y9MYA4	A0A2Y9N9G8	Homeobox protein DLX-2 isoform X1.	Homeobox protein DLX-1 isoform X1.	0.748
DLX2	HES5	A0A2Y9MYA4	A0A2Y9Q5N8	Homeobox protein DLX-2 isoform X1.	Transcription factor HES-5 isoform X1.	0.514
DLX2	OLIG2	A0A2Y9MYA4	A0A2Y9LG69	Homeobox protein DLX-2 isoform X1.	Oligodendrocyte transcription factor 2.	0.521
DLX2	SHH	A0A2Y9MYA4	A0A2Y9NDZ2	Homeobox protein DLX-2 isoform X1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.495
F2	SERPINE2	A0A2Y9PXE8	A0A2Y9MNF5	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Glia-derived nexin isoform X2; Belongs to the serpin family.	0.945