STRINGSTRING
CLUL1 CLUL1 NOP53 NOP53 SMAD7 SMAD7 PLK1 PLK1 HSPBP1 HSPBP1 LOC111182889 LOC111182889 HAMP HAMP PSMC5 PSMC5 NSF NSF CD81 CD81 RNF14 RNF14 AXIN2 AXIN2 APC APC CSNK1D CSNK1D ECSCR ECSCR PSMC3 PSMC3 GGA3 GGA3 STX5 STX5 SH3RF2 SH3RF2 NDFIP1 NDFIP1 TRIB3 TRIB3 DTL DTL C4BPB C4BPB DDB1 DDB1 PACSIN3 PACSIN3 CBLB CBLB AXIN1 AXIN1 ITCH ITCH DDRGK1 DDRGK1 CSNK2A1 CSNK2A1 SH3RF1 SH3RF1 RILP RILP BBS7 BBS7 SGSM3 SGSM3 LOC111186244 LOC111186244 GGA1 GGA1 PLK2 PLK2 RCHY1 RCHY1 RNFT2 RNFT2 TNFRSF1B TNFRSF1B SH3D19 SH3D19 WNT5A WNT5A TIPARP TIPARP PRICKLE1 PRICKLE1 SOCS5 SOCS5 ADAM8 ADAM8 LRRK2 LRRK2 ADRA2A ADRA2A USP13 USP13 SOCS4 SOCS4 SGTA SGTA TMEM259 TMEM259 PSMC6 PSMC6 DACT1 DACT1 BAG6 BAG6 AMER1 AMER1 FBXL5 FBXL5 ASB9 ASB9 DNAJB2 DNAJB2 DET1 DET1 ASB11 ASB11 UBQLN2 UBQLN2 NDUFA13 NDUFA13 MKRN2 MKRN2 GPLD1 GPLD1 CUL4B CUL4B MARCH2 MARCH2 LDLR LDLR SOX17 SOX17 RAD23A RAD23A SORL1 SORL1 SNX9 SNX9 EZR EZR SIRT6 SIRT6 UBQLN1 UBQLN1 MAPK9 MAPK9 DVL1 DVL1 DAB2 DAB2 RNF180 RNF180 SH3RF3 SH3RF3 FBXW7 FBXW7 FBXW8 FBXW8 TNF TNF IL1B IL1B RNFT1 RNFT1 HERPUD1 HERPUD1 RFWD2 RFWD2 TMTC3 TMTC3 RNF217 RNF217 TRIB1 TRIB1 PSMC2 PSMC2 LOC111170662 LOC111170662 TRIB2 TRIB2 RNF144A RNF144A PSMD10 PSMD10 KCNE2 KCNE2 RHBDD3 RHBDD3 CDC20B CDC20B NUB1 NUB1 TRIM32 TRIM32 RNF19B RNF19B USP5 USP5 ARIH2 ARIH2 NEDD4 NEDD4 OAZ2 OAZ2 PSEN1 PSEN1 CDKN1B CDKN1B LOC111177759 LOC111177759 ARIH1 ARIH1 ZER1 ZER1 SNX33 SNX33 DAB2IP DAB2IP CAV1 CAV1 PIAS1 PIAS1 LPCAT1 LPCAT1 RNF19A RNF19A EGLN2 EGLN2 TREM2 TREM2 FOXO1 FOXO1 ZYG11B ZYG11B PLK3 PLK3 IFNG IFNG ASB5 ASB5 PCSK9 PCSK9 PSMC1 PSMC1 LOC111175787 LOC111175787 ZYG11A ZYG11A RNF41 RNF41 NKD1 NKD1 VPS35 VPS35 VIP VIP BCAP31 BCAP31 RAB7A RAB7A AGPAT4 AGPAT4 MSN MSN GSK3B GSK3B OAZ3 OAZ3 SNF8 SNF8 OSBPL7 OSBPL7 VPS28 VPS28 OAZ1 OAZ1 YJEFN3 YJEFN3 TNFAIP3 TNFAIP3 FZR1 FZR1 GPC3 GPC3 RACK1 RACK1 DDA1 DDA1 GBA GBA FBXW9 FBXW9 NRDC NRDC BAG2 BAG2 CDC20 CDC20 FBXO22 FBXO22 ANKIB1 ANKIB1 PSMC4 PSMC4 RNF144B RNF144B GSK3A GSK3A SIRT2 SIRT2 SEC22B SEC22B CBFA2T3 CBFA2T3 NUPR1 NUPR1 MYLIP MYLIP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CLUL1Clusterin; Belongs to the clusterin family. (477 aa)
NOP53Ribosome biogenesis protein NOP53. (486 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
HSPBP1Hsp70-binding protein 1 isoform X1. (357 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
HAMPHepcidin isoform X2. (108 aa)
PSMC526S proteasome regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
NSFVesicle-fusing ATPase isoform X1. (777 aa)
CD81Tetraspanin. (236 aa)
RNF14RBR-type E3 ubiquitin transferase. (474 aa)
AXIN2Axin-2 isoform X1. (843 aa)
APCAdenomatous polyposis coli protein isoform X1. (2864 aa)
CSNK1DCasein kinase I isoform X4; Belongs to the protein kinase superfamily. (428 aa)
ECSCREndothelial cell-specific chemotaxis regulator isoform X5. (203 aa)
PSMC326S proteasome regulatory subunit 6A isoform X1; Belongs to the AAA ATPase family. (423 aa)
GGA3ADP-ribosylation factor-binding protein GGA3 isoform X1. (758 aa)
STX5Syntaxin-5; Belongs to the syntaxin family. (355 aa)
SH3RF2Putative E3 ubiquitin-protein ligase SH3RF2. (727 aa)
NDFIP1NEDD4 family-interacting protein 1. (221 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (357 aa)
DTLDenticleless protein homolog. (730 aa)
C4BPBC4b-binding protein beta chain isoform X1. (255 aa)
DDB1DNA damage-binding protein 1. (1140 aa)
PACSIN3Protein kinase C and casein kinase substrate in neurons protein 3. (424 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (983 aa)
AXIN1Axin-1 isoform X1. (866 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
DDRGK1DDRGK domain-containing protein 1. (348 aa)
CSNK2A1Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1 isoform X1. (872 aa)
RILPRab-interacting lysosomal protein isoform X1. (447 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
SGSM3Small G protein signaling modulator 3 isoform X1. (775 aa)
LOC111186244Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (416 aa)
GGA1ADP-ribosylation factor-binding protein GGA1 isoform X1. (648 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
RCHY1RING finger and CHY zinc finger domain-containing protein 1 isoform X1. (261 aa)
RNFT2RING finger and transmembrane domain-containing protein 2. (436 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (454 aa)
SH3D19SH3 domain-containing protein 19 isoform X1. (1082 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
TIPARPTCDD-inducible poly [ADP-ribose] polymerase. (657 aa)
PRICKLE1Prickle-like protein 1. (834 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8 isoform X1. (838 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2 isoform X1. (2527 aa)
ADRA2Aalpha-2A adrenergic receptor. (465 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (859 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
SGTASmall glutamine-rich tetratricopeptide repeat-containing protein alpha. (313 aa)
TMEM259Membralin isoform X1. (618 aa)
PSMC626S proteasome regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
DACT1Dapper homolog 1 isoform X1. (844 aa)
BAG6Large proline-rich protein BAG6 isoform X1. (1164 aa)
AMER1APC membrane recruitment protein 1. (1129 aa)
FBXL5F-box/LRR-repeat protein 5 isoform X2. (691 aa)
ASB9Ankyrin repeat and SOCS box protein 9 isoform X1. (294 aa)
DNAJB2dnaJ homolog subfamily B member 2 isoform X1. (325 aa)
DET1DET1 homolog isoform X1. (573 aa)
ASB11Ankyrin repeat and SOCS box protein 11 isoform X1. (323 aa)
UBQLN2LOW QUALITY PROTEIN: ubiquilin-2. (624 aa)
NDUFA13LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (164 aa)
MKRN2Probable E3 ubiquitin-protein ligase makorin-2. (416 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (849 aa)
CUL4Bcullin-4B isoform X1; Belongs to the cullin family. (904 aa)
MARCH2E3 ubiquitin-protein ligase MARCH2. (246 aa)
LDLRLow-density lipoprotein receptor. (857 aa)
SOX17Transcription factor SOX-17. (408 aa)
RAD23AUV excision repair protein RAD23 homolog A isoform X1. (363 aa)
SORL1Sortilin-related receptor isoform X1. (2211 aa)
SNX9Sorting nexin. (594 aa)
EZREzrin. (586 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X3. (375 aa)
UBQLN1Ubiquilin-1 isoform X1. (590 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (700 aa)
DAB2Disabled homolog 2 isoform X1. (769 aa)
RNF180E3 ubiquitin-protein ligase RNF180. (665 aa)
SH3RF3SH3 domain-containing RING finger protein 3. (828 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (707 aa)
FBXW8F-box/WD repeat-containing protein 8. (599 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
RNFT1RING finger and transmembrane domain-containing protein 1 isoform X1. (398 aa)
HERPUD1Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein. (387 aa)
RFWD2E3 ubiquitin-protein ligase RFWD2 isoform X1. (735 aa)
TMTC3Transmembrane and TPR repeat-containing protein 3 isoform X1. (915 aa)
RNF217RBR-type E3 ubiquitin transferase. (540 aa)
TRIB1Tribbles homolog 1. (372 aa)
PSMC226S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)
LOC111170662Heat shock 70 kDa protein 1B; Belongs to the heat shock protein 70 family. (641 aa)
TRIB2Tribbles homolog 2. (343 aa)
RNF144ARBR-type E3 ubiquitin transferase. (326 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
KCNE2Potassium voltage-gated channel subfamily E member 2. (123 aa)
RHBDD3Rhomboid domain-containing protein 3. (386 aa)
CDC20BCell division cycle protein 20 homolog B isoform X1. (549 aa)
NUB1NEDD8 ultimate buster 1 isoform X1. (638 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32 isoform X1. (699 aa)
RNF19BRBR-type E3 ubiquitin transferase. (732 aa)
USP5Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (858 aa)
ARIH2RBR-type E3 ubiquitin transferase. (491 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform X3. (1319 aa)
OAZ2LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 2. (189 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
LOC111177759LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 2-like. (189 aa)
ARIH1RBR-type E3 ubiquitin transferase. (555 aa)
ZER1Protein zer-1 homolog isoform X1. (766 aa)
SNX33Sorting nexin. (574 aa)
DAB2IPDisabled homolog 2-interacting protein isoform X1. (1193 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
PIAS1E3 SUMO-protein ligase PIAS1 isoform X1. (651 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1 isoform X1. (534 aa)
RNF19ARBR-type E3 ubiquitin transferase. (852 aa)
EGLN2Egl nine homolog 2. (402 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
FOXO1Forkhead box protein O1. (663 aa)
ZYG11BProtein zyg-11 homolog B isoform X1. (765 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ASB5Ankyrin repeat and SOCS box protein 5. (329 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9 isoform X1. (692 aa)
PSMC126S proteasome regulatory subunit 4 isoform X1; Belongs to the AAA ATPase family. (440 aa)
LOC111175787LOW QUALITY PROTEIN: cullin-4B-like; Belongs to the cullin family. (891 aa)
ZYG11AProtein zyg-11 homolog A. (756 aa)
RNF41E3 ubiquitin-protein ligase NRDP1 isoform X1. (317 aa)
NKD1Protein naked cuticle homolog 1. (471 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
VIPVIP peptides isoform X1. (170 aa)
BCAP31B-cell receptor-associated protein 31. (245 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
AGPAT41-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1. (835 aa)
MSNMoesin isoform X1. (579 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
OAZ3LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 3. (186 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
OSBPL7Oxysterol-binding protein; Belongs to the OSBP family. (924 aa)
VPS28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (221 aa)
OAZ1LOW QUALITY PROTEIN: ornithine decarboxylase antizyme 1. (227 aa)
YJEFN3yjeF N-terminal domain-containing protein 3 isoform X1. (312 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
FZR1Fizzy-related protein homolog isoform X1. (496 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
RACK1Receptor of activated protein C kinase 1. (317 aa)
DDA1DET1- and DDB1-associated protein 1. (102 aa)
GBAGlucosylceramidase. (585 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (461 aa)
NRDCNardilysin isoform X1. (1228 aa)
BAG2BAG family molecular chaperone regulator 2. (211 aa)
CDC20Cell division cycle protein 20 homolog. (499 aa)
FBXO22F-box only protein 22 isoform X1. (408 aa)
ANKIB1RBR-type E3 ubiquitin transferase. (1131 aa)
PSMC426S proteasome regulatory subunit 6B; Belongs to the AAA ATPase family. (418 aa)
RNF144BRBR-type E3 ubiquitin transferase. (372 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
SEC22BVesicle-trafficking protein SEC22b; Belongs to the synaptobrevin family. (215 aa)
CBFA2T3Protein CBFA2T3 isoform X1. (648 aa)
NUPR1Nuclear protein 1. (82 aa)
MYLIPE3 ubiquitin-protein ligase MYLIP. (445 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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