STRINGSTRING
KDR KDR FGF1 FGF1 ANGPT4 ANGPT4 CCL24 CCL24 SIRT1 SIRT1 THBS1 THBS1 ITGB8 ITGB8 SPHK1 SPHK1 PRKCA PRKCA HSPB6 HSPB6 PRKCB PRKCB PAK4 PAK4 HSPB1 HSPB1 GATA6 GATA6 GREM1 GREM1 CCBE1 CCBE1 AQP1 AQP1 RRAS RRAS EMC10 EMC10 C5AR1 C5AR1 JAK1 JAK1 APELA APELA CDH5 CDH5 PRKD2 PRKD2 FUT1 FUT1 ABL1 ABL1 BMPER BMPER PDCD6 PDCD6 EPHA1 EPHA1 PARP6 PARP6 HIPK2 HIPK2 VEGFA VEGFA C3AR1 C3AR1 ANGPTL3 ANGPTL3 C5 C5 JCAD JCAD CHRNA7 CHRNA7 EMILIN1 EMILIN1 AKT3 AKT3 ENG ENG NOS3 NOS3 ACVRL1 ACVRL1 LOC111174870 LOC111174870 PGF PGF TIE1 TIE1 ZC3H12A ZC3H12A FLT1 FLT1 HYAL1 HYAL1 WNT5A WNT5A SP1 SP1 CCR3 CCR3 AAMP AAMP TLR3 TLR3 RAPGEF3 RAPGEF3 VEGFC VEGFC HIF1A HIF1A ZNF304 ZNF304 LOC111170002 LOC111170002 VEGFD VEGFD CD40 CD40 GDF2 GDF2 ECM1 ECM1 DLL1 DLL1 S100A1 S100A1 SMOC2 SMOC2 HK2 HK2 CX3CR1 CX3CR1 MYDGF MYDGF TNN TNN CXCR3 CXCR3 SIRT6 SIRT6 TMIGD2 TMIGD2 LOC111165909 LOC111165909 RAMP2 RAMP2 LOC111166741 LOC111166741 BRCA1 BRCA1 STAT3 STAT3 VASH2 VASH2 VEGFB VEGFB APLNR APLNR AGGF1 AGGF1 CHI3L1 CHI3L1 LOC111185794 LOC111185794 PTGIS PTGIS JMJD8 JMJD8 PDPK1 PDPK1 PTK2B PTK2B FGF18 FGF18 IL1A IL1A PIK3R6 PIK3R6 ANXA3 ANXA3 SMAD1 SMAD1 GAB1 GAB1 PDCL3 PDCL3 SFRP2 SFRP2 HMOX1 HMOX1 IL1B IL1B JUP JUP LRG1 LRG1 EMP2 EMP2 NR2E1 NR2E1 ETS1 ETS1 ISL1 ISL1 TEK TEK AGO2 AGO2 CTSH CTSH PRKD1 PRKD1 XBP1 XBP1 F3 F3 BTG1 BTG1 EMILIN2 EMILIN2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
ANGPT4Angiopoietin-4. (498 aa)
CCL24C-C motif chemokine 24. (119 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
THBS1Thrombospondin-1. (1170 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
SPHK1Sphingosine kinase 1 isoform X2. (484 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
HSPB6Heat shock protein beta-6 isoform X1; Belongs to the small heat shock protein (HSP20) family. (175 aa)
PRKCBProtein kinase C. (689 aa)
PAK4Non-specific serine/threonine protein kinase. (594 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
GATA6Transcription factor GATA-6. (592 aa)
GREM1Gremlin. (184 aa)
CCBE1Collagen and calcium-binding EGF domain-containing protein 1 isoform X1. (407 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
RRASRas-related protein R-Ras isoform X1. (251 aa)
EMC10ER membrane protein complex subunit 10 isoform X1. (260 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (424 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (536 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
BMPERBMP-binding endothelial regulator protein isoform X1. (685 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
EPHA1Ephrin type-A receptor 1 isoform X1. (981 aa)
PARP6Poly [ADP-ribose] polymerase. (640 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1248 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
C3AR1C3a anaphylatoxin chemotactic receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (498 aa)
ANGPTL3Angiopoietin-related protein 3. (460 aa)
C5Complement C5 isoform X1. (1677 aa)
JCADJunctional protein associated with coronary artery disease. (1281 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7 isoform X2. (499 aa)
EMILIN1EMILIN-1. (1015 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
ENGEndoglin. (652 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
LOC111174870Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (543 aa)
PGFPlacenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (170 aa)
TIE1Tyrosine-protein kinase receptor Tie-1 isoform X1. (1139 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
HYAL1Hyaluronidase. (448 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
SP1Transcription factor Sp1. (786 aa)
CCR3C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (358 aa)
AAMPAngio-associated migratory cell protein isoform X1. (435 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X2. (958 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
ZNF304Zinc finger protein 304. (661 aa)
LOC111170002Zinc finger protein 304-like. (660 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (284 aa)
GDF2Growth/differentiation factor 2. (431 aa)
ECM1Extracellular matrix protein 1 isoform X1. (544 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (799 aa)
S100A1Protein S100; Belongs to the S-100 family. (94 aa)
SMOC2SPARC-related modular calcium-binding protein 2 isoform X1. (456 aa)
HK2Hexokinase-2. (917 aa)
CX3CR1CX3C chemokine receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
MYDGFMyeloid-derived growth factor isoform X1. (175 aa)
TNNtenascin-N. (1296 aa)
CXCR3C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X3. (375 aa)
TMIGD2Transmembrane and immunoglobulin domain-containing protein 2. (231 aa)
LOC111165909LOW QUALITY PROTEIN: phosducin-like protein 3. (237 aa)
RAMP2Receptor activity-modifying protein 2. (177 aa)
LOC111166741SAM and SH3 domain-containing protein 1 isoform X1. (1513 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1866 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
VASH2Vasohibin-2 isoform X1. (355 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (209 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
AGGF1Angiogenic factor with G patch and FHA domains 1. (714 aa)
CHI3L1LOW QUALITY PROTEIN: chitinase-3-like protein 1; Belongs to the glycosyl hydrolase 18 family. (393 aa)
LOC111185794C-C motif chemokine. (97 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
JMJD8jmjC domain-containing protein 8 isoform X1. (280 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6 isoform X1. (881 aa)
ANXA3Annexin. (323 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (757 aa)
PDCL3Phosducin-like protein 3. (240 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
JUPJunction plakoglobin. (744 aa)
LRG1Leucine-rich alpha-2-glycoprotein isoform X1. (354 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1 isoform X1. (385 aa)
ETS1Protein C-ets-1 isoform X1. (486 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (902 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (335 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (392 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
BTG1Protein BTG1. (171 aa)
EMILIN2EMILIN-2. (1070 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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