STRINGSTRING
PLIN5 PLIN5 IL1B IL1B TNF TNF STOML2 STOML2 PLA2G6 PLA2G6 MTOR MTOR DISP3 DISP3 NR1H4 NR1H4 SCARB1 SCARB1 PTK2B PTK2B EEF1A2 EEF1A2 CTDNEP1 CTDNEP1 PPARA PPARA LPGAT1 LPGAT1 PTGS2 PTGS2 PDGFB PDGFB F2 F2 TWIST1 TWIST1 DGKZ DGKZ SLC45A3 SLC45A3 FGF1 FGF1 NR1H3 NR1H3 STARD4 STARD4 MLXIPL MLXIPL AMBRA1 AMBRA1 CD74 CD74 PDGFRB PDGFRB KAT5 KAT5 DAGLB DAGLB CD81 CD81 SPHK2 SPHK2 AKT2 AKT2 CD19 CD19 BMP6 BMP6 TGFB1 TGFB1 NR1H2 NR1H2 VAV3 VAV3 ADGRF5 ADGRF5 ELOVL5 ELOVL5 MLYCD MLYCD CYR61 CYR61 PPARD PPARD ANGPTL3 ANGPTL3 SCAP SCAP CREBL2 CREBL2 HTR2A HTR2A VAV2 VAV2 IFNG IFNG IRS2 IRS2 AKT1 AKT1 PODN PODN PRKCD PRKCD ATG14 ATG14 MFSD2A MFSD2A FLT1 FLT1 PRKCE PRKCE ABHD6 ABHD6 ANXA1 ANXA1 HTR2B HTR2B ACSL3 ACSL3 ABCD2 ABCD2 CREB1 CREB1 IRS1 IRS1 ABCD1 ABCD1 SCT SCT PNPLA2 PNPLA2 PDGFRA PDGFRA APOA5 APOA5 SREBF1 SREBF1 SLC27A1 SLC27A1 CGA CGA GPLD1 GPLD1 APOA4 APOA4 PIK3R4 PIK3R4 LDLR LDLR ABCG4 ABCG4 RETN RETN LYN LYN PLA2G3 PLA2G3 CCL19 CCL19 FGR FGR EPHA8 EPHA8 CCL21 CCL21 SIRT4 SIRT4 CNEP1R1 CNEP1R1 NOD2 NOD2 TEK TEK MID1IP1 MID1IP1 ZBTB20 ZBTB20 APOA2 APOA2 APOA1 APOA1 NR1D1 NR1D1 ABHD5 ABHD5 HTR2C HTR2C FGFR3 FGFR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLIN5Perilipin; Belongs to the perilipin family. (454 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
STOML2Stomatin-like protein 2, mitochondrial. (356 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2 isoform X2. (835 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
DISP3Protein dispatched homolog 3 isoform X1. (1395 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
SCARB1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (511 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
CTDNEP1CTD nuclear envelope phosphatase 1 isoform X1. (244 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
LPGAT1acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1. (420 aa)
PTGS2Prostaglandin G/H synthase 2. (604 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
TWIST1Twist-related protein 1. (205 aa)
DGKZDiacylglycerol kinase. (1210 aa)
SLC45A3Solute carrier family 45 member 3. (553 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
NR1H3Oxysterols receptor LXR-alpha isoform X1. (447 aa)
STARD4stAR-related lipid transfer protein 4 isoform X1. (241 aa)
MLXIPLCarbohydrate-responsive element-binding protein isoform X1. (929 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1295 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
DAGLBSn1-specific diacylglycerol lipase beta isoform X1. (669 aa)
CD81Tetraspanin. (236 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CD19B-lymphocyte antigen CD19 isoform X1. (570 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
NR1H2Oxysterols receptor LXR-beta isoform X1. (450 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
ADGRF5Adhesion G protein-coupled receptor F5 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1408 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (295 aa)
MLYCDmalonyl-CoA decarboxylase, mitochondrial isoform X1. (528 aa)
CYR61Protein CYR61. (382 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
ANGPTL3Angiopoietin-related protein 3. (460 aa)
SCAPSterol regulatory element-binding protein cleavage-activating protein isoform X1. (1280 aa)
CREBL2cAMP-responsive element-binding protein-like 2 isoform X1. (147 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (879 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PODNPodocan. (607 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
ATG14Beclin 1-associated autophagy-related key regulator. (492 aa)
MFSD2ASodium-dependent lysophosphatidylcholine symporter 1 isoform X1. (565 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
PRKCEProtein kinase C. (746 aa)
ABHD6Monoacylglycerol lipase ABHD6. (337 aa)
ANXA1Annexin. (346 aa)
HTR2B5-hydroxytryptamine receptor 2B. (490 aa)
ACSL3long-chain-fatty-acid--CoA ligase 3. (720 aa)
ABCD2ATP-binding cassette sub-family D member 2. (741 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
ABCD1ATP-binding cassette sub-family D member 1 isoform X1. (774 aa)
SCTSecretin. (134 aa)
PNPLA2Patatin-like phospholipase domain-containing protein 2 isoform X1. (489 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
APOA5Apolipoprotein A-V isoform X1. (390 aa)
SREBF1Sterol regulatory element-binding protein 1 isoform X1. (1213 aa)
SLC27A1Long-chain fatty acid transport protein 1 isoform X1. (675 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (849 aa)
APOA4Apolipoprotein A-IV isoform X1. (380 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
LDLRLow-density lipoprotein receptor. (857 aa)
ABCG4ATP-binding cassette sub-family G member 4 isoform X1. (646 aa)
RETNResistin isoform X2. (158 aa)
LYNTyrosine-protein kinase. (518 aa)
PLA2G3Group 3 secretory phospholipase A2 isoform X1. (516 aa)
CCL19C-C motif chemokine. (159 aa)
FGRTyrosine-protein kinase. (526 aa)
EPHA8Ephrin type-A receptor 8. (1005 aa)
CCL21C-C motif chemokine 21 isoform X1. (131 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
CNEP1R1Nuclear envelope phosphatase-regulatory subunit 1 isoform X1. (125 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
TEKAngiopoietin-1 receptor. (1125 aa)
MID1IP1Mid1-interacting protein 1. (183 aa)
ZBTB20Zinc finger and BTB domain-containing protein 20 isoform X1. (741 aa)
APOA2Apolipoprotein A-II. (103 aa)
APOA1Apolipoprotein A-I. (265 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
ABHD51-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X1. (389 aa)
HTR2C5-hydroxytryptamine receptor 2C. (456 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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