(43 nodes) Regulation of glucose import network (Delphinapterus leucas)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	GRB10	Growth factor receptor-bound protein 10 isoform X1. (588 aa)
	Ob	Leptin isoform X1. (167 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
	POU4F2	POU domain protein. (407 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
	APPL2	DCC-interacting protein 13-beta isoform X2. (661 aa)
	IGF1	Insulin-like growth factor I isoform X1. (186 aa)
	MEF2A	Myocyte-specific enhancer factor 2A isoform X1. (501 aa)
	LOC111187339	LOW QUALITY PROTEIN: growth factor receptor-bound protein 10-like. (665 aa)
	C1QTNF12	Adipolin. (299 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	RNASEL	2-5A-dependent ribonuclease isoform X1. (665 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	ASPSCR1	Tether containing UBX domain for GLUT4 isoform X1. (575 aa)
	STXBP3	Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
	GSK3A	Glycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	RTN2	Reticulon. (471 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1203 aa)
	SLC1A2	Amino acid transporter. (574 aa)
	OPN3	LOW QUALITY PROTEIN: opsin-3. (515 aa)
	CREBL2	cAMP-responsive element-binding protein-like 2 isoform X1. (147 aa)
	RLN1	Prorelaxin H1. (183 aa)
	IRS2	Insulin receptor substrate 2. (1347 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	NFE2L2	Nuclear factor erythroid 2-related factor 2 isoform X1. (622 aa)
	RHOQ	Rho-related GTP-binding protein RhoQ. (169 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (707 aa)
	CAPN10	Calpain-10 isoform X1; Belongs to the peptidase C2 family. (704 aa)
	APPL1	DCC-interacting protein 13-alpha isoform X1. (708 aa)
	OSTN	Osteocrin. (132 aa)
	PID1	PTB-containing, cubilin and LRP1-interacting protein isoform X1. (268 aa)
	ERFE	Erythroferrone isoform X1. (367 aa)
	IRS1	Insulin receptor substrate 1. (1248 aa)
	HK2	Hexokinase-2. (917 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1. (925 aa)
	PEA15	Astrocytic phosphoprotein PEA-15. (130 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (889 aa)
	GPC3	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
	INSR	Tyrosine-protein kinase receptor. (1392 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	A0A2Y9NBQ2	A0A2Y9PDM4	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT1	APPL1	A0A2Y9NBQ2	A0A2Y9N2T5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	DCC-interacting protein 13-alpha isoform X1.	0.793
AKT1	APPL2	A0A2Y9NBQ2	A0A2Y9QDV1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	DCC-interacting protein 13-beta isoform X2.	0.783
AKT1	GSK3A	A0A2Y9NBQ2	A0A2Y9P7P1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily.	0.951
AKT1	IGF1	A0A2Y9NBQ2	A0A2Y9QDF3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin-like growth factor I isoform X1.	0.467
AKT1	INS	A0A2Y9NBQ2	A0A2Y9PTW5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.556
AKT1	IRS1	A0A2Y9NBQ2	A0A2Y9MMM9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.529
AKT1	IRS2	A0A2Y9NBQ2	A0A2Y9NC55	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 2.	0.446
AKT1	NFE2L2	A0A2Y9NBQ2	A0A2Y9N981	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor erythroid 2-related factor 2 isoform X1.	0.567
AKT1	PIK3R1	A0A2Y9NBQ2	A0A2Y9Q8T5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.964
AKT1	TNF	A0A2Y9NBQ2	Q8WNR1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.434
AKT2	AKT1	A0A2Y9PDM4	A0A2Y9NBQ2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.900
AKT2	APPL1	A0A2Y9PDM4	A0A2Y9N2T5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	DCC-interacting protein 13-alpha isoform X1.	0.793
AKT2	APPL2	A0A2Y9PDM4	A0A2Y9QDV1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	DCC-interacting protein 13-beta isoform X2.	0.783
AKT2	GSK3A	A0A2Y9PDM4	A0A2Y9P7P1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily.	0.951
AKT2	IGF1	A0A2Y9PDM4	A0A2Y9QDF3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin-like growth factor I isoform X1.	0.467
AKT2	INS	A0A2Y9PDM4	A0A2Y9PTW5	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.556
AKT2	IRS1	A0A2Y9PDM4	A0A2Y9MMM9	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 1.	0.529
AKT2	IRS2	A0A2Y9PDM4	A0A2Y9NC55	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin receptor substrate 2.	0.446
AKT2	NFE2L2	A0A2Y9PDM4	A0A2Y9N981	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor erythroid 2-related factor 2 isoform X1.	0.567