STRINGSTRING
NEDD4 NEDD4 CDK5 CDK5 SMO SMO DMAP1 DMAP1 EFCAB7 EFCAB7 GAS6 GAS6 IPO5 IPO5 HYAL2 HYAL2 DNAJC27 DNAJC27 SHH SHH IFNG IFNG NRDE2 NRDE2 PRKCD PRKCD ZC3H12A ZC3H12A KHDRBS1 KHDRBS1 XPO4 XPO4 SETD2 SETD2 FRAT1 FRAT1 NF1 NF1 YWHAE YWHAE CAMK1 CAMK1 CABP1 CABP1 SFN SFN MDN1 MDN1 PRKD1 PRKD1 LOC111163806 LOC111163806 FERMT1 FERMT1 JUP JUP SIRT7 SIRT7 CHP2 CHP2 IWS1 IWS1 LEP LEP NUP153 NUP153 RIOK2 RIOK2 LOC111183699 LOC111183699 PTPN14 PTPN14 PKIG PKIG HDAC3 HDAC3 RBM22 RBM22 DHX9 DHX9 TPR TPR MAVS MAVS GLI3 GLI3 TRIM28 TRIM28 UHMK1 UHMK1 APOD APOD BAG3 BAG3 BMP4 BMP4 PPM1A PPM1A ECT2 ECT2 TCF7L2 TCF7L2 CPSF6 CPSF6 RAPGEF3 RAPGEF3 EMD EMD PPP1CC PPP1CC PIK3R1 PIK3R1 ANP32B ANP32B XPO1 XPO1 PTPN11 PTPN11 PARK7 PARK7 Ob Ob FLNA FLNA HCLS1 HCLS1 GSK3B GSK3B ZPR1 ZPR1 AKAP8L AKAP8L PPP1R12A PPP1R12A EPM2A EPM2A SIRT6 SIRT6 PRKACA PRKACA PIK3R2 PIK3R2 LOC111186315 LOC111186315 SUPT6H SUPT6H TARDBP TARDBP PTPN22 PTPN22 CTDSPL2 CTDSPL2 CDH1 CDH1 TGFB1 TGFB1 RAB23 RAB23 UBR5 UBR5 NUP214 NUP214 NSUN2 NSUN2 PSEN1 PSEN1 MDFI MDFI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform X3. (1319 aa)
CDK5Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
DMAP1DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa)
EFCAB7EF-hand calcium-binding domain-containing protein 7 isoform X1. (656 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
IPO5Importin-5. (1097 aa)
HYAL2Hyaluronidase. (476 aa)
DNAJC27dnaJ homolog subfamily C member 27 isoform X1. (273 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
NRDE2Protein NRDE2 homolog isoform X1. (1165 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
KHDRBS1KH domain-containing, RNA-binding, signal transduction-associated protein 1. (443 aa)
XPO4Exportin-4 isoform X1. (1152 aa)
SETD2Histone-lysine N-methyltransferase SETD2 isoform X1. (2570 aa)
FRAT1Proto-oncogene FRAT1. (279 aa)
NF1Neurofibromin isoform X1. (2873 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1; Belongs to the protein kinase superfamily. (370 aa)
CABP1Calcium-binding protein 1 isoform X1. (427 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
MDN1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5597 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
LOC111163806LOW QUALITY PROTEIN: interferon-induced GTP-binding protein Mx2-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (332 aa)
FERMT1Fermitin family homolog 1. (677 aa)
JUPJunction plakoglobin. (744 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7 isoform X1. (400 aa)
CHP2Calcineurin B homologous protein 2. (198 aa)
IWS1Protein IWS1 homolog isoform X1. (821 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
NUP153Nuclear pore complex protein Nup153 isoform X1. (1477 aa)
RIOK2Serine/threonine-protein kinase RIO2. (552 aa)
LOC111183699RNA-binding protein 4 isoform X1. (363 aa)
PTPN14Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1187 aa)
PKIGcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
RBM22pre-mRNA-splicing factor RBM22 isoform X1. (420 aa)
DHX9ATP-dependent RNA helicase A isoform X1. (1253 aa)
TPRNucleoprotein TPR isoform X2. (2438 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (581 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1587 aa)
TRIM28Transcription intermediary factor 1-beta. (837 aa)
UHMK1Serine/threonine-protein kinase Kist. (419 aa)
APODApolipoprotein D. (213 aa)
BAG3BAG family molecular chaperone regulator 3. (577 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
PPM1AProtein phosphatase 1A. (382 aa)
ECT2Protein ECT2 isoform X1. (973 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (668 aa)
CPSF6Cleavage and polyadenylation specificity factor subunit 6 isoform X1. (589 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X2. (958 aa)
EMDEmerin isoform X1. (261 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
ANP32BAcidic leucine-rich nuclear phosphoprotein 32 family member B. (261 aa)
XPO1Exportin-1 isoform X1. (1071 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
PARK7Protein DJ-1. (189 aa)
ObLeptin isoform X1. (167 aa)
FLNAfilamin-A isoform X1. (2647 aa)
HCLS1Hematopoietic lineage cell-specific protein. (481 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
ZPR1Zinc finger protein ZPR1. (459 aa)
AKAP8LA-kinase anchor protein 8-like isoform X1; Belongs to the AKAP95 family. (649 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1030 aa)
EPM2ALaforin isoform X1. (331 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X3. (375 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
LOC111186315Ran GTPase-activating protein 1. (569 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
TARDBPTAR DNA-binding protein 43. (414 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
CTDSPL2CTD small phosphatase-like protein 2 isoform X1. (465 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
RAB23Ras-related protein Rab-23. (237 aa)
UBR5E3 ubiquitin-protein ligase UBR5 isoform X1. (2798 aa)
NUP214Nuclear pore complex protein Nup214 isoform X1. (2100 aa)
NSUN2tRNA (Cytosine(34)-C(5))-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (741 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
MDFImyoD family inhibitor isoform X1. (302 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.