STRINGSTRING
PRKCD PRKCD IFNG IFNG SHH SHH HYAL2 HYAL2 IPO5 IPO5 GAS6 GAS6 EFCAB7 EFCAB7 DMAP1 DMAP1 SMO SMO NEDD4 NEDD4 MAVS MAVS PSEN1 PSEN1 UBR5 UBR5 TGFB1 TGFB1 CDH1 CDH1 CTDSPL2 CTDSPL2 PTPN22 PTPN22 CHP2 CHP2 Ob Ob ANP32B ANP32B PIK3R1 PIK3R1 YWHAE YWHAE TARDBP TARDBP GLI3 GLI3 TPR TPR DHX9 DHX9 RBM22 RBM22 HDAC3 HDAC3 RIOK2 RIOK2 LEP LEP SFN SFN PRKD1 PRKD1 JUP JUP PIK3R2 PIK3R2 PRKACA PRKACA SIRT6 SIRT6 ZPR1 ZPR1 GSK3B GSK3B HCLS1 HCLS1 FLNA FLNA EMD EMD CAMK1 CAMK1 TRIM28 TRIM28 BAG3 BAG3 PPM1A PPM1A ECT2 ECT2 TCF7L2 TCF7L2 CPSF6 CPSF6 RAPGEF3 RAPGEF3 XPO4 XPO4 KHDRBS1 KHDRBS1 ZC3H12A ZC3H12A NRDE2 NRDE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (733 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
HYAL2Hyaluronidase. (476 aa)
IPO5Importin-5. (1097 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
EFCAB7EF-hand calcium-binding domain-containing protein 7 isoform X1. (656 aa)
DMAP1DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
NEDD4E3 ubiquitin-protein ligase NEDD4 isoform X3. (1319 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (581 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
UBR5E3 ubiquitin-protein ligase UBR5 isoform X1. (2798 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
CTDSPL2CTD small phosphatase-like protein 2 isoform X1. (465 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
CHP2Calcineurin B homologous protein 2. (198 aa)
ObLeptin isoform X1. (167 aa)
ANP32BAcidic leucine-rich nuclear phosphoprotein 32 family member B. (261 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
TARDBPTAR DNA-binding protein 43. (414 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1587 aa)
TPRNucleoprotein TPR isoform X2. (2438 aa)
DHX9ATP-dependent RNA helicase A isoform X1. (1253 aa)
RBM22pre-mRNA-splicing factor RBM22 isoform X1. (420 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
RIOK2Serine/threonine-protein kinase RIO2. (552 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
JUPJunction plakoglobin. (744 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform X3. (375 aa)
ZPR1Zinc finger protein ZPR1. (459 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
HCLS1Hematopoietic lineage cell-specific protein. (481 aa)
FLNAfilamin-A isoform X1. (2647 aa)
EMDEmerin isoform X1. (261 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1; Belongs to the protein kinase superfamily. (370 aa)
TRIM28Transcription intermediary factor 1-beta. (837 aa)
BAG3BAG family molecular chaperone regulator 3. (577 aa)
PPM1AProtein phosphatase 1A. (382 aa)
ECT2Protein ECT2 isoform X1. (973 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (668 aa)
CPSF6Cleavage and polyadenylation specificity factor subunit 6 isoform X1. (589 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3 isoform X2. (958 aa)
XPO4Exportin-4 isoform X1. (1152 aa)
KHDRBS1KH domain-containing, RNA-binding, signal transduction-associated protein 1. (443 aa)
ZC3H12AEndoribonuclease ZC3H12A. (583 aa)
NRDE2Protein NRDE2 homolog isoform X1. (1165 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.