43 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LIF	Leukemia inhibitory factor. (202 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	PLA2G1B	Phospholipase A(2). (160 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	LOC111165935	Ras-like protein isoform X1. (285 aa)
	NGFR	Tumor necrosis factor receptor superfamily member 16. (427 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	PDGFA	Platelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (196 aa)
	WAPL	Wings apart-like protein homolog isoform X1. (1196 aa)
	DDR2	Discoidin domain-containing receptor 2. (565 aa)
	LOC111169254	Discoidin domain-containing receptor 2-like. (323 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	HRAS	GTPase HRas isoform X1. (189 aa)
	BRK1	Protein BRICK1. (75 aa)
	FNDC3B	Fibronectin type III domain-containing protein 3B isoform X1. (1215 aa)
	FN1	Fibronectin isoform X5. (2478 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
	JUN	Transcription factor AP-1; Belongs to the bZIP family. (343 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	FOSL2	Fos-related antigen 2 isoform X1. (327 aa)
	GAS6	Growth arrest-specific protein 6. (671 aa)
	BMI1	Polycomb complex protein BMI-1. (326 aa)
	LIG4	DNA ligase. (911 aa)
	PML	Protein PML isoform X1. (861 aa)
	PDGFC	Platelet-derived growth factor C isoform X2. (380 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (164 aa)
	CDK6	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	AQP1	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	FBRS	Probable fibrosin-1. (985 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (789 aa)
	SPHK1	Sphingosine kinase 1 isoform X2. (484 aa)
	CD74	HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
	ZMIZ1	Zinc finger MIZ domain-containing protein 1 isoform X1. (1071 aa)
	DHX9	ATP-dependent RNA helicase A isoform X1. (1253 aa)
	CD248	Endosialin. (764 aa)
	E2F1	Transcription factor E2F1. (437 aa)
	PDGFB	Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
	CTC1	CST complex subunit CTC1 isoform X1. (1210 aa)
	EREG	Proepiregulin. (163 aa)
	NDUFS4	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial. (175 aa)
	IGF1	Insulin-like growth factor I isoform X1. (186 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMI1	E2F1	A0A2Y9NM47	A0A2Y9PYG0	Polycomb complex protein BMI-1.	Transcription factor E2F1.	0.459
BMI1	MYC	A0A2Y9NM47	A0A2Y9LJB2	Polycomb complex protein BMI-1.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.470
CDK6	CDKN1A	A0A2Y9P3B0	A0A2Y9NTU9	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1.	0.996
CDK6	E2F1	A0A2Y9P3B0	A0A2Y9PYG0	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	Transcription factor E2F1.	0.746
CDK6	ESR1	A0A2Y9P3B0	A0A2Y9M1Z4	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.496
CDK6	FBRS	A0A2Y9P3B0	A0A2Y9PAL4	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	Probable fibrosin-1.	0.477
CDK6	MYC	A0A2Y9P3B0	A0A2Y9LJB2	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.418
CDK6	WAPL	A0A2Y9P3B0	A0A2Y9MAV7	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	Wings apart-like protein homolog isoform X1.	0.408
CDKN1A	CDK6	A0A2Y9NTU9	A0A2Y9P3B0	Cyclin-dependent kinase inhibitor 1.	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	0.996
CDKN1A	E2F1	A0A2Y9NTU9	A0A2Y9PYG0	Cyclin-dependent kinase inhibitor 1.	Transcription factor E2F1.	0.637
CDKN1A	ESR1	A0A2Y9NTU9	A0A2Y9M1Z4	Cyclin-dependent kinase inhibitor 1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.582
CDKN1A	JUN	A0A2Y9NTU9	A0A2Y9NBA9	Cyclin-dependent kinase inhibitor 1.	Transcription factor AP-1; Belongs to the bZIP family.	0.514
CDKN1A	MYC	A0A2Y9NTU9	A0A2Y9LJB2	Cyclin-dependent kinase inhibitor 1.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.509
DDR2	LOC111169254	A0A2Y9MB91	A0A2Y9MBA1	Discoidin domain-containing receptor 2.	Discoidin domain-containing receptor 2-like.	0.895
E2F1	BMI1	A0A2Y9PYG0	A0A2Y9NM47	Transcription factor E2F1.	Polycomb complex protein BMI-1.	0.459
E2F1	CDK6	A0A2Y9PYG0	A0A2Y9P3B0	Transcription factor E2F1.	Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily.	0.746
E2F1	CDKN1A	A0A2Y9PYG0	A0A2Y9NTU9	Transcription factor E2F1.	Cyclin-dependent kinase inhibitor 1.	0.637
E2F1	ESR1	A0A2Y9PYG0	A0A2Y9M1Z4	Transcription factor E2F1.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.535
E2F1	JUN	A0A2Y9PYG0	A0A2Y9NBA9	Transcription factor E2F1.	Transcription factor AP-1; Belongs to the bZIP family.	0.513
E2F1	MYC	A0A2Y9PYG0	A0A2Y9LJB2	Transcription factor E2F1.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.659