STRINGSTRING
SHISA9 SHISA9 GRIN2A GRIN2A MAPK1 MAPK1 NOG NOG EPHB2 EPHB2 GRIK2 GRIK2 JPH4 JPH4 ADCY8 ADCY8 RELN RELN NFATC4 NFATC4 SNAP25 SNAP25 ARC ARC NR2E1 NR2E1 LRRTM1 LRRTM1 LOC111165935 LOC111165935 RASGRF1 RASGRF1 GIPC3 GIPC3 SORCS2 SORCS2 CBLN1 CBLN1 RAB3A RAB3A NTRK2 NTRK2 RAB5A RAB5A IGSF11 IGSF11 DRD2 DRD2 ADGRB1 ADGRB1 NETO1 NETO1 NRGN NRGN KAT2A KAT2A NEUROD2 NEUROD2 TNR TNR CHRDL1 CHRDL1 NCSTN NCSTN KCNJ10 KCNJ10 GIPC1 GIPC1 SQSTM1 SQSTM1 KMT2A KMT2A LZTS1 LZTS1 CX3CR1 CX3CR1 DBN1 DBN1 MPP2 MPP2 GFAP GFAP HRAS HRAS SYAP1 SYAP1 SNAP47 SNAP47 SCT SCT AGER AGER SYP SYP MECP2 MECP2 SCGN SCGN RGS14 RGS14 SERPINE2 SERPINE2 NEURL1 NEURL1 SLC4A10 SLC4A10 AKAP5 AKAP5 PRRT1 PRRT1 SORCS3 SORCS3 DRD5 DRD5 EPHA4 EPHA4 SLC24A2 SLC24A2 ABHD6 ABHD6 LOC111175442 LOC111175442 NCDN NCDN ERC2 ERC2 KRAS KRAS LOC111176091 LOC111176091 SYNPR SYNPR STXBP1 STXBP1 ANAPC2 ANAPC2 APP APP UNC13C UNC13C LGMN LGMN PTN PTN ERC1 ERC1 NPTN NPTN RIMS3 RIMS3 CDC20 CDC20 GRIN2B GRIN2B CDK5 CDK5 BRAF BRAF NSMF NSMF SRF SRF PSEN1 PSEN1 CALB2 CALB2 GRID2 GRID2 LOC111179149 LOC111179149 SYNGAP1 SYNGAP1 ABL1 ABL1 JPH3 JPH3 CRHR2 CRHR2 RIMS2 RIMS2 DGKI DGKI GRIN2D GRIN2D ITPR3 ITPR3 CALB1 CALB1 GIPC2 GIPC2 GRID2IP GRID2IP PRRT2 PRRT2 SLC8A2 SLC8A2 SHISA7 SHISA7 ACE ACE EIF4EBP2 EIF4EBP2 GRIN2C GRIN2C VGF VGF ITPKA ITPKA GRIA1 GRIA1 CLN3 CLN3 YWHAG YWHAG LRRTM2 LRRTM2 BAIAP2 BAIAP2 STX3 STX3 CNTN2 CNTN2 NPAS4 NPAS4 RIMS1 RIMS1 ADCY1 ADCY1 SYT12 SYT12 P2RX3 P2RX3 ZZEF1 ZZEF1 ATF4 ATF4 DLG4 DLG4 SYNGR1 SYNGR1 RASGRF2 RASGRF2 GRM5 GRM5 SHANK3 SHANK3 PICK1 PICK1 SHISA8 SHISA8 S100B S100B CPLX2 CPLX2 PLK2 PLK2 KCNB1 KCNB1 SHISA6 SHISA6 NF1 NF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHISA9Protein shisa-9 isoform X1. (466 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1464 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
EPHB2Ephrin type-B receptor 2 isoform X1. (987 aa)
GRIK2Glutamate receptor ionotropic, kainate 2 isoform X2. (908 aa)
JPH4Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (699 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
RELNReelin isoform X1. (3460 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (901 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1 isoform X1. (385 aa)
LRRTM1Leucine-rich repeat transmembrane neuronal protein 1. (522 aa)
LOC111165935Ras-like protein isoform X1. (285 aa)
RASGRF1Ras-specific guanine nucleotide-releasing factor 1 isoform X1. (1278 aa)
GIPC3PDZ domain-containing protein GIPC3. (318 aa)
SORCS2VPS10 domain-containing receptor SorCS2 isoform X1. (1171 aa)
CBLN1Cerebellin-1. (193 aa)
RAB3ARas-related protein Rab-3A. (220 aa)
NTRK2Tyrosine-protein kinase receptor. (822 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
IGSF11Immunoglobulin superfamily member 11 isoform X1. (373 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
ADGRB1Brain-specific angiogenesis inhibitor 1 isoform X1. (888 aa)
NETO1Neuropilin and tolloid-like protein 1 isoform X1. (532 aa)
NRGNNeurogranin. (78 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (878 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
TNRtenascin-R isoform X1. (1358 aa)
CHRDL1Chordin-like protein 1 isoform X1. (527 aa)
NCSTNNicastrin. (709 aa)
KCNJ10ATP-sensitive inward rectifier potassium channel 10. (379 aa)
GIPC1PDZ domain-containing protein GIPC1. (333 aa)
SQSTM1Sequestosome-1. (440 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4012 aa)
LZTS1Leucine zipper putative tumor suppressor 1. (591 aa)
CX3CR1CX3C chemokine receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
DBN1Drebrin isoform X1. (699 aa)
MPP2MAGUK p55 subfamily member 2 isoform X5; Belongs to the MAGUK family. (569 aa)
GFAPGlial fibrillary acidic protein isoform X1; Belongs to the intermediate filament family. (470 aa)
HRASGTPase HRas isoform X1. (189 aa)
SYAP1Synapse-associated protein 1 isoform X1. (358 aa)
SNAP47Synaptosomal-associated protein 47 isoform X3. (420 aa)
SCTSecretin. (134 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
SYPSynaptophysin. (313 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
SCGNSecretagogin. (276 aa)
RGS14Regulator of G-protein signaling 14 isoform X1. (604 aa)
SERPINE2Glia-derived nexin isoform X2; Belongs to the serpin family. (397 aa)
NEURL1E3 ubiquitin-protein ligase NEURL1 isoform X1. (574 aa)
SLC4A10Anion exchange protein. (1147 aa)
AKAP5A-kinase anchor protein 5. (428 aa)
PRRT1Proline-rich transmembrane protein 1. (305 aa)
SORCS3VPS10 domain-containing receptor SorCS3 isoform X1. (1222 aa)
DRD5LOW QUALITY PROTEIN: D(1B) dopamine receptor. (217 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
SLC24A2Sodium/potassium/calcium exchanger 2 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (665 aa)
ABHD6Monoacylglycerol lipase ABHD6. (337 aa)
LOC11117544214-3-3 protein gamma-like; Belongs to the 14-3-3 family. (153 aa)
NCDNNeurochondrin isoform X1. (729 aa)
ERC2ERC protein 2 isoform X2. (957 aa)
KRASGTPase KRas. (188 aa)
LOC111176091Cholesterol 24-hydroxylase isoform X1; Belongs to the cytochrome P450 family. (501 aa)
SYNPRSynaptoporin isoform X1. (285 aa)
STXBP1Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (820 aa)
APPAmyloid beta A4 protein isoform X1. (767 aa)
UNC13CProtein unc-13 homolog C isoform X1. (2217 aa)
LGMNLegumain. (433 aa)
PTNPleiotrophin isoform X1. (168 aa)
ERC1ELKS/Rab6-interacting/CAST family member 1 isoform X1. (1123 aa)
NPTNNeuroplastin isoform X1. (398 aa)
RIMS3Regulating synaptic membrane exocytosis protein 3. (308 aa)
CDC20Cell division cycle protein 20 homolog. (499 aa)
GRIN2BGlutamate receptor ionotropic, NMDA 2B. (1499 aa)
CDK5Cyclin-dependent-like kinase 5; Belongs to the protein kinase superfamily. (292 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor isoform X1. (532 aa)
SRFSerum response factor isoform X2. (535 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
CALB2Calretinin. (272 aa)
GRID2Glutamate receptor ionotropic, delta-2 isoform X1. (1007 aa)
LOC11117914914-3-3 protein gamma-like; Belongs to the 14-3-3 family. (246 aa)
SYNGAP1ras/Rap GTPase-activating protein SynGAP isoform X1. (1345 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
JPH3Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (739 aa)
CRHR2Corticotropin-releasing factor receptor 2 isoform X1; Belongs to the G-protein coupled receptor 2 family. (537 aa)
RIMS2Regulating synaptic membrane exocytosis protein 2 isoform X2. (1549 aa)
DGKIDiacylglycerol kinase. (1079 aa)
GRIN2DLOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D. (1334 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3 isoform X1. (2671 aa)
CALB1Calbindin. (261 aa)
GIPC2PDZ domain-containing protein GIPC2. (311 aa)
GRID2IPLOW QUALITY PROTEIN: delphilin. (1214 aa)
PRRT2Proline-rich transmembrane protein 2 isoform X1. (448 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
SHISA7Protein shisa-7 isoform X1. (677 aa)
ACEAngiotensin-converting enzyme. (1310 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E-binding protein 2. (120 aa)
GRIN2CGlutamate receptor ionotropic, NMDA 2C isoform X1. (1265 aa)
VGFNeurosecretory protein VGF. (616 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (460 aa)
GRIA1Glutamate receptor 1 isoform X1. (906 aa)
CLN3Battenin. (436 aa)
YWHAG14-3-3 protein gamma; Belongs to the 14-3-3 family. (247 aa)
LRRTM2Leucine-rich repeat transmembrane neuronal protein 2 isoform X1. (516 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2. (522 aa)
STX3Syntaxin-3 isoform X1; Belongs to the syntaxin family. (289 aa)
CNTN2Contactin-2. (1043 aa)
NPAS4Neuronal PAS domain-containing protein 4. (798 aa)
RIMS1Regulating synaptic membrane exocytosis protein 1 isoform X44. (1678 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
SYT12Synaptotagmin-12 isoform X1. (422 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (397 aa)
ZZEF1Zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform X1. (3008 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (350 aa)
DLG4Disks large homolog 4 isoform X1; Belongs to the MAGUK family. (752 aa)
SYNGR1Synaptogyrin. (232 aa)
RASGRF2Ras-specific guanine nucleotide-releasing factor 2 isoform X1. (1240 aa)
GRM5Metabotropic glutamate receptor 5 isoform X1. (1208 aa)
SHANK3SH3 and multiple ankyrin repeat domains protein 3 isoform X1. (1733 aa)
PICK1PRKCA-binding protein isoform X1. (417 aa)
SHISA8Uncharacterized protein. (399 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
CPLX2Complexin-2. (134 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
SHISA6LOW QUALITY PROTEIN: protein shisa-6 homolog. (554 aa)
NF1Neurofibromin isoform X1. (2873 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.