(16 nodes) Paraxial mesoderm development network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TEAD2	Transcriptional enhancer factor TEF-4 isoform X3. (239 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	EXOC4	Exocyst complex component 4. (975 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
	LEF1	Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
	YAP1	Transcriptional coactivator YAP1 isoform X1. (511 aa)
	EPB41L5	Band 4.1-like protein 5 isoform X1. (726 aa)
	POGLUT1	Protein O-glucosyltransferase 1 isoform X1. (392 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	DLL3	Delta-like protein 3. (586 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	NUP133	Nuclear pore complex protein Nup133. (1156 aa)
	ZIC3	Zinc finger protein ZIC 3 isoform X1. (464 aa)
	HNF1A	Hepatocyte nuclear factor 1-alpha. (632 aa)
	TCF15	Transcription factor 15. (197 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMPR1A	LEF1	A0A2Y9M7N1	A0A2Y9MLC4	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Lymphoid enhancer-binding factor 1 isoform X1.	0.615
BMPR1A	SMAD3	A0A2Y9M7N1	A0A2Y9NWL7	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.958
BMPR1A	YAP1	A0A2Y9M7N1	A0A2Y9MKS8	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transcriptional coactivator YAP1 isoform X1.	0.438
DLL3	WNT3A	A0A2Y9P5M5	A0A2Y9MBH2	Delta-like protein 3.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.466
LEF1	BMPR1A	A0A2Y9MLC4	A0A2Y9M7N1	Lymphoid enhancer-binding factor 1 isoform X1.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.615
LEF1	SMAD3	A0A2Y9MLC4	A0A2Y9NWL7	Lymphoid enhancer-binding factor 1 isoform X1.	Mothers against decapentaplegic homolog.	0.673
LEF1	TEAD2	A0A2Y9MLC4	A0A2Y9PBZ9	Lymphoid enhancer-binding factor 1 isoform X1.	Transcriptional enhancer factor TEF-4 isoform X3.	0.820
LEF1	WNT11	A0A2Y9MLC4	A0A2Y9PRI0	Lymphoid enhancer-binding factor 1 isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.557
LEF1	WNT3A	A0A2Y9MLC4	A0A2Y9MBH2	Lymphoid enhancer-binding factor 1 isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.654
LEF1	WNT5A	A0A2Y9MLC4	A0A2Y9N641	Lymphoid enhancer-binding factor 1 isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.570
LEF1	YAP1	A0A2Y9MLC4	A0A2Y9MKS8	Lymphoid enhancer-binding factor 1 isoform X1.	Transcriptional coactivator YAP1 isoform X1.	0.837
SMAD3	BMPR1A	A0A2Y9NWL7	A0A2Y9M7N1	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.958
SMAD3	LEF1	A0A2Y9NWL7	A0A2Y9MLC4	Mothers against decapentaplegic homolog.	Lymphoid enhancer-binding factor 1 isoform X1.	0.673
SMAD3	YAP1	A0A2Y9NWL7	A0A2Y9MKS8	Mothers against decapentaplegic homolog.	Transcriptional coactivator YAP1 isoform X1.	0.960
TEAD2	LEF1	A0A2Y9PBZ9	A0A2Y9MLC4	Transcriptional enhancer factor TEF-4 isoform X3.	Lymphoid enhancer-binding factor 1 isoform X1.	0.820
TEAD2	YAP1	A0A2Y9PBZ9	A0A2Y9MKS8	Transcriptional enhancer factor TEF-4 isoform X3.	Transcriptional coactivator YAP1 isoform X1.	0.998
WNT11	LEF1	A0A2Y9PRI0	A0A2Y9MLC4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Lymphoid enhancer-binding factor 1 isoform X1.	0.557
WNT11	WNT3A	A0A2Y9PRI0	A0A2Y9MBH2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.522
WNT11	WNT5A	A0A2Y9PRI0	A0A2Y9N641	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.440
WNT3A	DLL3	A0A2Y9MBH2	A0A2Y9P5M5	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Delta-like protein 3.	0.466