(17 nodes) Sympathetic nervous system development network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NTRK1	Tyrosine-protein kinase receptor. (795 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	PHOX2B	Paired mesoderm homeobox protein 2B. (311 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (931 aa)
	PHOX2A	Paired mesoderm homeobox protein 2A. (285 aa)
	SEMA3F	semaphorin-3F isoform X1; Belongs to the semaphorin family. (785 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	TFAP2B	Transcription factor AP-2-beta isoform X1. (467 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	PLXNA4	plexin-A4 isoform X1. (1981 aa)
	SOX4	Transcription factor SOX. (477 aa)
	FZD3	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	HAND2	LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2. (217 aa)
	NF1	Neurofibromin isoform X1. (2873 aa)
	GDNF	Glial cell line-derived neurotrophic factor. (185 aa)
	EDNRA	Endothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	ASCL1	Achaete-scute homolog 1. (225 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	GDNF	A0A2Y9QJY2	A0A2Y9QAQ2	Achaete-scute homolog 1.	Glial cell line-derived neurotrophic factor.	0.438
ASCL1	PHOX2A	A0A2Y9QJY2	A0A2Y9MR39	Achaete-scute homolog 1.	Paired mesoderm homeobox protein 2A.	0.633
ASCL1	PHOX2B	A0A2Y9QJY2	A0A2Y9MLH6	Achaete-scute homolog 1.	Paired mesoderm homeobox protein 2B.	0.518
ASCL1	SOX4	A0A2Y9QJY2	A0A2Y9P5V4	Achaete-scute homolog 1.	Transcription factor SOX.	0.440
CTNNB1	FZD3	A0A2Y9MAY9	A0A2Y9PYV8	Catenin beta-1.	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.683
CTNNB1	SOX4	A0A2Y9MAY9	A0A2Y9P5V4	Catenin beta-1.	Transcription factor SOX.	0.657
FZD3	CTNNB1	A0A2Y9PYV8	A0A2Y9MAY9	Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family.	Catenin beta-1.	0.683
GATA3	HAND2	A0A2Y9P1J9	A0A2Y9PZH1	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2.	0.567
GATA3	PHOX2B	A0A2Y9P1J9	A0A2Y9MLH6	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Paired mesoderm homeobox protein 2B.	0.514
GDNF	ASCL1	A0A2Y9QAQ2	A0A2Y9QJY2	Glial cell line-derived neurotrophic factor.	Achaete-scute homolog 1.	0.438
HAND2	GATA3	A0A2Y9PZH1	A0A2Y9P1J9	LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.567
HAND2	PHOX2A	A0A2Y9PZH1	A0A2Y9MR39	LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2.	Paired mesoderm homeobox protein 2A.	0.687
HAND2	PHOX2B	A0A2Y9PZH1	A0A2Y9MLH6	LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2.	Paired mesoderm homeobox protein 2B.	0.624
HAND2	SOX4	A0A2Y9PZH1	A0A2Y9P5V4	LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2.	Transcription factor SOX.	0.426
NRP2	PLXNA4	A0A2Y9MQJ7	A0A2Y9P2Z6	Neuropilin; Belongs to the neuropilin family.	plexin-A4 isoform X1.	0.631
NRP2	SEMA3F	A0A2Y9MQJ7	A0A2Y9N266	Neuropilin; Belongs to the neuropilin family.	semaphorin-3F isoform X1; Belongs to the semaphorin family.	0.878
PHOX2A	ASCL1	A0A2Y9MR39	A0A2Y9QJY2	Paired mesoderm homeobox protein 2A.	Achaete-scute homolog 1.	0.633
PHOX2A	HAND2	A0A2Y9MR39	A0A2Y9PZH1	Paired mesoderm homeobox protein 2A.	LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2.	0.687
PHOX2B	ASCL1	A0A2Y9MLH6	A0A2Y9QJY2	Paired mesoderm homeobox protein 2B.	Achaete-scute homolog 1.	0.518
PHOX2B	GATA3	A0A2Y9MLH6	A0A2Y9P1J9	Paired mesoderm homeobox protein 2B.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.514