(32 nodes) Animal organ formation network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	GLI3	Transcriptional activator GLI3 isoform X1. (1587 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
	SMARCD3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D. (483 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	LEMD2	LEM domain-containing protein 2 isoform X1. (515 aa)
	HOXA3	Homeobox protein Hox-A3. (443 aa)
	GATA6	Transcription factor GATA-6. (592 aa)
	NTF4	Neurotrophin-4; Belongs to the NGF-beta family. (247 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
	TBR1	T-box brain protein 1. (681 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
	LRP2	Low-density lipoprotein receptor-related protein 2. (4838 aa)
	BMP4	Bone morphogenetic protein 4 isoform X2. (408 aa)
	NKX3-2	Homeobox protein Nkx-3.2. (327 aa)
	FOLR1	Folate receptor alpha. (251 aa)
	MESP1	Mesoderm posterior protein 1. (265 aa)
	AXIN2	Axin-2 isoform X1. (843 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	AR	Androgen receptor. (893 aa)
	FOXH1	Forkhead box protein H1. (360 aa)
	EMP2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
	EXT1	Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform X6. (483 aa)
	ISL1	Insulin gene enhancer protein ISL-1. (349 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	MAPK1	Mitogen-activated protein kinase. (380 aa)
	SELENOH	Selenoprotein H. (122 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CTNNB1	A0A2Y9M4V8	A0A2Y9MAY9	Androgen receptor.	Catenin beta-1.	0.865
AXIN2	BMP4	A0A2Y9PJS0	A0A2Y9MV04	Axin-2 isoform X1.	Bone morphogenetic protein 4 isoform X2.	0.515
AXIN2	CTNNB1	A0A2Y9PJS0	A0A2Y9MAY9	Axin-2 isoform X1.	Catenin beta-1.	0.994
AXIN2	LRP2	A0A2Y9PJS0	A0A2Y9MVK7	Axin-2 isoform X1.	Low-density lipoprotein receptor-related protein 2.	0.529
AXIN2	NOG	A0A2Y9PJS0	A0A2Y9LFG3	Axin-2 isoform X1.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.506
AXIN2	SHH	A0A2Y9PJS0	A0A2Y9NDZ2	Axin-2 isoform X1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.495
AXIN2	WNT11	A0A2Y9PJS0	A0A2Y9PRI0	Axin-2 isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.621
AXIN2	WNT5A	A0A2Y9PJS0	A0A2Y9N641	Axin-2 isoform X1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.694
BMP4	AXIN2	A0A2Y9MV04	A0A2Y9PJS0	Bone morphogenetic protein 4 isoform X2.	Axin-2 isoform X1.	0.515
BMP4	BMPR1A	A0A2Y9MV04	A0A2Y9M7N1	Bone morphogenetic protein 4 isoform X2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.994
BMP4	CTNNB1	A0A2Y9MV04	A0A2Y9MAY9	Bone morphogenetic protein 4 isoform X2.	Catenin beta-1.	0.619
BMP4	FGF10	A0A2Y9MV04	A0A2Y9LQ50	Bone morphogenetic protein 4 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.765
BMP4	GATA6	A0A2Y9MV04	A0A2Y9PB94	Bone morphogenetic protein 4 isoform X2.	Transcription factor GATA-6.	0.597
BMP4	ISL1	A0A2Y9MV04	A0A2Y9LQ30	Bone morphogenetic protein 4 isoform X2.	Insulin gene enhancer protein ISL-1.	0.510
BMP4	NOG	A0A2Y9MV04	A0A2Y9LFG3	Bone morphogenetic protein 4 isoform X2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.995
BMP4	SHH	A0A2Y9MV04	A0A2Y9NDZ2	Bone morphogenetic protein 4 isoform X2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.683
BMP4	WNT11	A0A2Y9MV04	A0A2Y9PRI0	Bone morphogenetic protein 4 isoform X2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.418
BMP4	WNT5A	A0A2Y9MV04	A0A2Y9N641	Bone morphogenetic protein 4 isoform X2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.539
BMPR1A	BMP4	A0A2Y9M7N1	A0A2Y9MV04	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4 isoform X2.	0.994
BMPR1A	NOG	A0A2Y9M7N1	A0A2Y9LFG3	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.661