(103 nodes) Embryonic skeletal system development network (Delphinapterus leucas)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	SCX	Basic helix-loop-helix transcription factor scleraxis isoform X2. (203 aa)
	EXT1	Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
	MKS1	Meckel syndrome type 1 protein isoform X3. (618 aa)
	LHX1	LIM/homeobox protein Lhx1. (406 aa)
	IRX5	Iroquois-class homeodomain protein IRX-5. (484 aa)
	HOXB8	Homeobox protein Hox-B8. (243 aa)
	HOXB3	LOW QUALITY PROTEIN: homeobox protein Hox-B3. (421 aa)
	MMP14	Matrix metalloproteinase-14. (582 aa)
	HOXB5	Homeobox protein Hox-B5. (269 aa)
	HOXB1	Homeobox protein Hox-B1. (298 aa)
	HOXB7	Homeobox protein Hox-B7. (217 aa)
	HOXB9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
	HOXB2	Homeobox protein Hox-B2. (353 aa)
	HOXB4	Homeobox protein Hox-B4. (251 aa)
	MTHFD1L	Monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1. (975 aa)
	SLC39A1	Zinc transporter ZIP1. (324 aa)
	DSCAML1	Down syndrome cell adhesion molecule-like protein 1. (2113 aa)
	PCGF2	Polycomb group RING finger protein 2. (411 aa)
	HOXB6	Homeobox protein Hox-B6. (224 aa)
	COL1A1	Collagen alpha-1(I) chain. (1463 aa)
	MYF5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
	CTNNB1	Catenin beta-1. (781 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	SLC2A10	Solute carrier family 2, facilitated glucose transporter member 10 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (572 aa)
	MED12	Mediator of RNA polymerase II transcription subunit 12. (2177 aa)
	WDR19	WD repeat-containing protein 19 isoform X1. (1342 aa)
	MMP16	Matrix metalloproteinase-16. (548 aa)
	TAPT1	Transmembrane anterior posterior transformation protein 1 homolog. (759 aa)
	NKX3-2	Homeobox protein Nkx-3.2. (327 aa)
	FGFR2	Fibroblast growth factor receptor. (841 aa)
	DLG1	Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	HOXD10	Homeobox protein Hox-D10. (340 aa)
	BMP4	Bone morphogenetic protein 4 isoform X2. (408 aa)
	HOXD9	Homeobox protein Hox-D9. (343 aa)
	HOXD4	Homeobox protein Hox-D4. (255 aa)
	SATB2	DNA-binding protein SATB. (733 aa)
	SIX4	Homeobox protein SIX4 isoform X1. (790 aa)
	SLC39A3	Zinc transporter ZIP3. (314 aa)
	HOXC11	Homeobox protein Hox-C11. (305 aa)
	DLX2	Homeobox protein DLX-2 isoform X1. (333 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	HOXD1	Homeobox protein Hox-D1. (326 aa)
	HOXC4	Homeobox protein Hox-C4. (264 aa)
	SETD2	Histone-lysine N-methyltransferase SETD2 isoform X1. (2570 aa)
	DMRT2	Doublesex- and mab-3-related transcription factor 2 isoform X1. (230 aa)
	COL2A1	Collagen alpha-1(II) chain. (1487 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	HYAL1	Hyaluronidase. (448 aa)
	HOXC9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	SHOX2	Short stature homeobox protein 2 isoform X1. (329 aa)
	SP3	Transcription factor Sp3 isoform X1. (796 aa)
	ALX1	ALX homeobox protein 1. (326 aa)
	HOXD3	Homeobox protein Hox-D3. (432 aa)
	SIX2	Homeobox protein SIX2. (296 aa)
	DLX1	Homeobox protein DLX-1 isoform X1. (255 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
	HOXC6	Homeobox protein Hox-C6 isoform X1. (235 aa)
	GSC	Homeobox protein goosecoid. (256 aa)
	PCSK5	Proprotein convertase subtilisin/kexin type 5 isoform X2; Belongs to the peptidase S8 family. (1877 aa)
	TULP3	Tubby-like protein; Belongs to the TUB family. (465 aa)
	WDR60	WD repeat-containing protein 60 isoform X1. (1053 aa)
	BMI1	Polycomb complex protein BMI-1. (326 aa)
	RUNX2	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (524 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	UCMA	Unique cartilage matrix-associated protein. (138 aa)
	ALX3	Homeobox protein aristaless-like 3. (343 aa)
	KIAA1217	Sickle tail protein homolog isoform X1. (1982 aa)
	HOXA2	Homeobox protein Hox-A2. (372 aa)
	MEGF8	LOW QUALITY PROTEIN: multiple epidermal growth factor-like domains protein 8. (2784 aa)
	ZEB1	Zinc finger E-box-binding homeobox 1 isoform X2. (1110 aa)
	HOXA9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
	HOXA6	Homeobox protein Hox-A6. (233 aa)
	HOXA5	Homeobox protein Hox-A5. (381 aa)
	OSR2	Protein odd-skipped-related 2 isoform X1. (312 aa)
	TFAP2A	Transcription factor AP-2-alpha isoform X1. (439 aa)
	HOXA3	Homeobox protein Hox-A3. (443 aa)
	TBX15	T-box transcription factor TBX15. (602 aa)
	FUZ	Protein fuzzy homolog isoform X1. (474 aa)
	HOXA7	Homeobox protein Hox-A7. (233 aa)
	EIF4A3	Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family. (411 aa)
	HOXA11	Homeobox protein Hox-A11. (313 aa)
	NDST1	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform X1. (882 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	ALX4	Homeobox protein aristaless-like 4. (406 aa)
	TWIST1	Twist-related protein 1. (205 aa)
	DLG2	Disks large homolog 2 isoform X1. (994 aa)
	IFT140	Intraflagellar transport protein 140 homolog isoform X1. (1489 aa)
	HAND2	LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2. (217 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (589 aa)
	GLI3	Transcriptional activator GLI3 isoform X1. (1587 aa)
	FLVCR1	Feline leukemia virus subgroup C receptor-related protein 1 isoform X1. (555 aa)
	SULF1	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (882 aa)
	CHST11	Carbohydrate sulfotransferase. (418 aa)
	BMP7	Bone morphogenetic protein 7. (431 aa)
	EDNRA	Endothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	PAX5	Paired box protein Pax-5 isoform X2. (391 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
	NIPBL	Nipped-B protein. (2803 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX1	HAND2	A0A2Y9LER6	A0A2Y9PZH1	ALX homeobox protein 1.	LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2.	0.449
ALX3	PCSK5	A0A2Y9P0U9	A0A2Y9NIS5	Homeobox protein aristaless-like 3.	Proprotein convertase subtilisin/kexin type 5 isoform X2; Belongs to the peptidase S8 family.	0.440
ALX4	GLI3	A0A2Y9PRZ1	A0A2Y9Q038	Homeobox protein aristaless-like 4.	Transcriptional activator GLI3 isoform X1.	0.464
ALX4	HAND2	A0A2Y9PRZ1	A0A2Y9PZH1	Homeobox protein aristaless-like 4.	LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2.	0.446
ALX4	RUNX2	A0A2Y9PRZ1	A0A2Y9NUN3	Homeobox protein aristaless-like 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.406
BMI1	CTNNB1	A0A2Y9NM47	A0A2Y9MAY9	Polycomb complex protein BMI-1.	Catenin beta-1.	0.525
BMI1	HOXA7	A0A2Y9NM47	A0A2Y9PFB2	Polycomb complex protein BMI-1.	Homeobox protein Hox-A7.	0.405
BMI1	PCGF2	A0A2Y9NM47	A0A2Y9M2C8	Polycomb complex protein BMI-1.	Polycomb group RING finger protein 2.	0.931
BMI1	RUNX2	A0A2Y9NM47	A0A2Y9NUN3	Polycomb complex protein BMI-1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.416
BMI1	SHH	A0A2Y9NM47	A0A2Y9NDZ2	Polycomb complex protein BMI-1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.447
BMI1	TWIST1	A0A2Y9NM47	A0A2Y9PS80	Polycomb complex protein BMI-1.	Twist-related protein 1.	0.598
BMI1	ZEB1	A0A2Y9NM47	A0A2Y9P2L6	Polycomb complex protein BMI-1.	Zinc finger E-box-binding homeobox 1 isoform X2.	0.504
BMP4	BMP7	A0A2Y9MV04	A0A2Y9QCJ3	Bone morphogenetic protein 4 isoform X2.	Bone morphogenetic protein 7.	0.802
BMP4	COL1A1	A0A2Y9MV04	A0A2Y9M8V2	Bone morphogenetic protein 4 isoform X2.	Collagen alpha-1(I) chain.	0.477
BMP4	COL2A1	A0A2Y9MV04	A0A2Y9N4L6	Bone morphogenetic protein 4 isoform X2.	Collagen alpha-1(II) chain.	0.413
BMP4	CTNNB1	A0A2Y9MV04	A0A2Y9MAY9	Bone morphogenetic protein 4 isoform X2.	Catenin beta-1.	0.619
BMP4	FGF8	A0A2Y9MV04	A0A2Y9N7L2	Bone morphogenetic protein 4 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.605
BMP4	FGF9	A0A2Y9MV04	A0A2Y9N649	Bone morphogenetic protein 4 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.587
BMP4	FGFR2	A0A2Y9MV04	A0A2Y9MQL8	Bone morphogenetic protein 4 isoform X2.	Fibroblast growth factor receptor.	0.476
BMP4	HAND2	A0A2Y9MV04	A0A2Y9PZH1	Bone morphogenetic protein 4 isoform X2.	LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2.	0.495