STRINGSTRING
PCK2 PCK2 ID2 ID2 ZIC3 ZIC3 HGF HGF RPGRIP1L RPGRIP1L TBX2 TBX2 DKK3 DKK3 TPH1 TPH1 ISL1 ISL1 FGF10 FGF10 EXT1 EXT1 SEMA3C SEMA3C PRKCSH PRKCSH RB1CC1 RB1CC1 TCF21 TCF21 ELK1 ELK1 PLAG1 PLAG1 SALL1 SALL1 HOXB3 HOXB3 CDK5RAP3 CDK5RAP3 STAT5A STAT5A LOC111166483 LOC111166483 SEC63 SEC63 HOXB9 HOXB9 MED1 MED1 LATS1 LATS1 HOXB13 HOXB13 PTCH1 PTCH1 BMP2 BMP2 APOA1 APOA1 HNF1B HNF1B XBP1 XBP1 POU3F2 POU3F2 NOG NOG SOCS2 SOCS2 MAPK1 MAPK1 TWSG1 TWSG1 RHBDD3 RHBDD3 LAMA1 LAMA1 OTP OTP CRKL CRKL SMARCB1 SMARCB1 TBX3 TBX3 HNF1A HNF1A PDX1 PDX1 WNT5A WNT5A TNFSF11 TNFSF11 FGF8 FGF8 CSMD2 CSMD2 TP63 TP63 SP3 SP3 ATF2 ATF2 HOXD3 HOXD3 NKX2-1 NKX2-1 PCSK9 PCSK9 JUN JUN FGL1 FGL1 IRS2 IRS2 POLB POLB NFIB NFIB AGAP2 AGAP2 ZMPSTE24 ZMPSTE24 GLI1 GLI1 SHH SHH NR5A1 NR5A1 BCL11B BCL11B PHB2 PHB2 SLC46A2 SLC46A2 ZDHHC21 ZDHHC21 ONECUT1 ONECUT1 GSX1 GSX1 TGFB2 TGFB2 LHX3 LHX3 SMO SMO HLX HLX LOC111178657 LOC111178657 BRAF BRAF SRF SRF PML PML LRRC1 LRRC1 TGFB3 TGFB3 PSEN1 PSEN1 ATP2C2 ATP2C2 CDKN1B CDKN1B PKD2 PKD2 FOXB1 FOXB1 SLC6A3 SLC6A3 NOTCH1 NOTCH1 SMAD3 SMAD3 E2F8 E2F8 ABL1 ABL1 FOXF1 FOXF1 IGSF3 IGSF3 DNAAF1 DNAAF1 EZH2 EZH2 TNC TNC ESRP2 ESRP2 SMAD4 SMAD4 STRA6 STRA6 CAV1 CAV1 MAP2K1 MAP2K1 FEM1B FEM1B GATA3 GATA3 UPF2 UPF2 ONECUT2 ONECUT2 CEBPG CEBPG LOC111180037 LOC111180037 ACADM ACADM RXFP1 RXFP1 SERPINB5 SERPINB5 TNFRSF11A TNFRSF11A NFKB1 NFKB1 WNT2 WNT2 HOXA9 HOXA9 HOXA5 HOXA5 TGFB1 TGFB1 JARID2 JARID2 FA2H FA2H ARHGAP35 ARHGAP35 NPHP3 NPHP3 PAX6 PAX6 BCL2 BCL2 LSR LSR WT1 WT1 HOXA3 HOXA3 NOTCH2 NOTCH2 GATA6 GATA6 CSF1 CSF1 PITX1 PITX1 CRHR1 CRHR1 FASN FASN MAPK3 MAPK3 SLC9A3R1 SLC9A3R1 LOC111182889 LOC111182889 GHRHR GHRHR HOXA13 HOXA13 WNT3 WNT3 USF2 USF2 PRL PRL EDN1 EDN1 FGF7 FGF7 TFCP2L1 TFCP2L1 FADD FADD CCND1 CCND1 CCDC40 CCDC40 RELA RELA SELENOH SELENOH WNT11 WNT11 SOSTDC1 SOSTDC1 MAFB MAFB SRC SRC PAX1 PAX1 GFER GFER NRG3 NRG3 LRP5 LRP5 LOC111184719 LOC111184719 MAN2A1 MAN2A1 PROX1 PROX1 NKX2-5 NKX2-5 HNF4A HNF4A TGM2 TGM2 ADA ADA PKD1 PKD1 ASXL1 ASXL1 HAND2 HAND2 GHRH GHRH COBL COBL GLI3 GLI3 SERPINF1 SERPINF1 CTC1 CTC1 LOC111184716 LOC111184716 FOXN1 FOXN1 LOC111185794 LOC111185794 AIRE AIRE NKX3-1 NKX3-1 ALDH1A3 ALDH1A3 NTN1 NTN1 PTCD2 PTCD2 NF1 NF1 CEBPB CEBPB BCL2L11 BCL2L11 LAMA5 LAMA5 ORAI1 ORAI1 AREG AREG EPHA2 EPHA2 SOX10 SOX10 BMP7 BMP7 PCK1 PCK1 EDNRA EDNRA DDX55 DDX55 TGFBR1 TGFBR1 LOC111187154 LOC111187154 UBE3A UBE3A PAX8 PAX8 ZNF330 ZNF330 ASCL1 ASCL1 FOXE1 FOXE1 TNF TNF IL6 IL6 DRD2 DRD2 PYGO2 PYGO2 CADM1 CADM1 ACER1 ACER1 ESR1 ESR1 ARID5B ARID5B TGFA TGFA AR AR CUNH6orf58 CUNH6orf58 LOC111168242 LOC111168242 ATM ATM CSN3 CSN3 KDM5B KDM5B ZBTB7B ZBTB7B BMPR1A BMPR1A PLXNA1 PLXNA1 PLXND1 PLXND1 CITED2 CITED2 LOC111166328 LOC111166328 ASH1L ASH1L CSN2 CSN2 E2F7 E2F7 CTNNB1 CTNNB1 WNT3A WNT3A PDGFRA PDGFRA MSN MSN NR0B1 NR0B1 BSX BSX EDA EDA DDR1 DDR1 EAF2 EAF2 NOTCH4 NOTCH4 ELF3 ELF3 MSX1 MSX1 LEF1 LEF1 RAF1 RAF1 SERPINE2 SERPINE2 FRZB FRZB WNT10A WNT10A TAF10 TAF10 MAD1L1 MAD1L1 MKI67 MKI67 NEURL1 NEURL1 ERBB4 ERBB4 NKX2-3 NKX2-3 CUL3 CUL3 PROP1 PROP1 CACNB4 CACNB4 BTRC BTRC BMP4 BMP4 HOXD9 HOXD9 GDF7 GDF7 SRP54 SRP54 FOXA1 FOXA1 VDR VDR ANXA1 ANXA1 MST1 MST1 GPAT4 GPAT4 HES1 HES1 STAT6 STAT6 SIX1 SIX1 PIK3CA PIK3CA CLCN2 CLCN2 EPHB3 EPHB3 RARG RARG CCDC39 CCDC39 HIF1A HIF1A ZBTB1 ZBTB1 ZNF703 ZNF703 FRS2 FRS2 CSMD1 CSMD1 SFRP1 SFRP1 ARF6 ARF6 STK11 STK11 CREB1 CREB1 SIX4 SIX4 HOXD13 HOXD13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1. (655 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
ZIC3Zinc finger protein ZIC 3 isoform X1. (464 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
RPGRIP1LProtein fantom. (1269 aa)
TBX2T-box transcription factor TBX2. (713 aa)
DKK3Dickkopf-related protein 3. (349 aa)
TPH1Tryptophan 5-hydroxylase 1. (455 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
PRKCSHGlucosidase 2 subunit beta isoform X1. (535 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1589 aa)
TCF21Transcription factor 21. (179 aa)
ELK1LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1. (442 aa)
PLAG1Zinc finger protein PLAG1 isoform X1. (499 aa)
SALL1Sal-like protein 1. (1317 aa)
HOXB3LOW QUALITY PROTEIN: homeobox protein Hox-B3. (421 aa)
CDK5RAP3CDK5 regulatory subunit-associated protein 3 isoform X1. (544 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
SEC63Translocation protein SEC63 homolog. (760 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
LATS1Serine/threonine-protein kinase LATS1. (1128 aa)
HOXB13Homeobox protein Hox-B13. (285 aa)
PTCH1Protein patched homolog 1 isoform X1. (1447 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
APOA1Apolipoprotein A-I. (265 aa)
HNF1BHepatocyte nuclear factor 1-beta isoform X1. (558 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (392 aa)
POU3F2POU domain protein. (438 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
RHBDD3Rhomboid domain-containing protein 3. (386 aa)
LAMA1Laminin subunit alpha-1 isoform X1. (3081 aa)
OTPHomeobox protein orthopedia. (325 aa)
CRKLCrk-like protein. (303 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
TBX3T-box transcription factor TBX3 isoform X1. (745 aa)
HNF1AHepatocyte nuclear factor 1-alpha. (632 aa)
PDX1Pancreas/duodenum homeobox protein 1. (289 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CSMD2CUB and sushi domain-containing protein 2. (3609 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SP3Transcription factor Sp3 isoform X1. (796 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
HOXD3Homeobox protein Hox-D3. (432 aa)
NKX2-1Homeobox protein Nkx-2.1 isoform X1. (396 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9 isoform X1. (692 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (343 aa)
FGL1Fibrinogen-like protein 1. (315 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
AGAP2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1. (1192 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (473 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1106 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
NR5A1Steroidogenic factor 1 isoform X1. (461 aa)
BCL11BB-cell lymphoma/leukemia 11B isoform X1. (903 aa)
PHB2Prohibitin. (299 aa)
SLC46A2Thymic stromal cotransporter homolog. (475 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
ONECUT1One cut domain family member. (465 aa)
GSX1GS homeobox 1. (263 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LHX3LIM/homeobox protein Lhx3 isoform X1. (403 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
HLXH2.0-like homeobox protein. (488 aa)
LOC111178657Leucine-rich repeat-containing protein 1-like isoform X1. (174 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (762 aa)
SRFSerum response factor isoform X2. (535 aa)
PMLProtein PML isoform X1. (861 aa)
LRRC1Leucine-rich repeat-containing protein 1. (395 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (955 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
PKD2Polycystin-2 isoform X1. (975 aa)
FOXB1Forkhead box protein B1. (325 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
E2F8Transcription factor E2F8. (866 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
FOXF1Forkhead box protein F1. (375 aa)
IGSF3Immunoglobulin superfamily member 3. (1191 aa)
DNAAF1Dynein assembly factor 1, axonemal. (680 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (747 aa)
TNCTenascin isoform X1. (2201 aa)
ESRP2Epithelial splicing regulatory protein 2 isoform X3. (717 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
STRA6Stimulated by retinoic acid gene 6 protein homolog. (668 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
FEM1BProtein fem-1 homolog B. (627 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
UPF2Regulator of nonsense transcripts 2. (1270 aa)
ONECUT2One cut domain family member. (509 aa)
CEBPGCCAAT/enhancer-binding protein gamma. (149 aa)
LOC111180037Methylosome protein 50-like. (290 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial. (421 aa)
RXFP1Relaxin receptor 1 isoform X1. (785 aa)
SERPINB5Serpin B5; Belongs to the serpin family. (375 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A isoform X1. (551 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
HOXA5Homeobox protein Hox-A5. (381 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
JARID2Protein Jumonji isoform X1. (1235 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (396 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
NPHP3Nephrocystin-3 isoform X1. (1345 aa)
PAX6Paired box protein Pax-6 isoform X1. (493 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
LSRLipolysis-stimulated lipoprotein receptor isoform X3. (634 aa)
WT1Wilms tumor protein isoform X1. (450 aa)
HOXA3Homeobox protein Hox-A3. (443 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2471 aa)
GATA6Transcription factor GATA-6. (592 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
PITX1Homeobox protein. (314 aa)
CRHR1Corticotropin-releasing factor receptor 1 isoform X1; Belongs to the G-protein coupled receptor 2 family. (475 aa)
FASNFatty acid synthase isoform X1. (2680 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
GHRHRGrowth hormone-releasing hormone receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (427 aa)
HOXA13Homeobox protein Hox-A13. (387 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
USF2Upstream stimulatory factor 2. (347 aa)
PRLProlactin isoform X1. (230 aa)
EDN1Endothelin-1. (202 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TFCP2L1Transcription factor CP2-like protein 1 isoform X1. (493 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CCDC40Coiled-coil domain-containing protein 40 isoform X1. (1132 aa)
RELATranscription factor p65 isoform X1. (562 aa)
SELENOHSelenoprotein H. (122 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SOSTDC1Sclerostin domain-containing protein 1. (206 aa)
MAFBTranscription factor MafB. (323 aa)
SRCTyrosine-protein kinase. (562 aa)
PAX1Paired box protein Pax-1. (448 aa)
GFERSulfhydryl oxidase. (206 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform isoform X2. (725 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1622 aa)
LOC111184719Interferon regulatory factor 6 isoform X1. (467 aa)
MAN2A1Alpha-mannosidase. (1145 aa)
PROX1Prospero homeobox protein 1 isoform X1. (738 aa)
NKX2-5Homeobox protein Nkx-2.5. (323 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (484 aa)
TGM2Protein-glutamine gamma-glutamyltransferase 2. (687 aa)
ADAAdenosine deaminase isoform X1. (416 aa)
PKD1Polycystin-1 isoform X1. (4335 aa)
ASXL1LOW QUALITY PROTEIN: putative Polycomb group protein ASXL1. (1545 aa)
HAND2LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2. (217 aa)
GHRHSomatoliberin. (106 aa)
COBLProtein cordon-bleu isoform X3. (1381 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1587 aa)
SERPINF1Pigment epithelium-derived factor isoform X1; Belongs to the serpin family. (416 aa)
CTC1CST complex subunit CTC1 isoform X1. (1210 aa)
LOC111184716Interferon regulatory factor 6 isoform X2. (485 aa)
FOXN1Forkhead box protein N1. (645 aa)
LOC111185794C-C motif chemokine. (97 aa)
AIREAutoimmune regulator. (553 aa)
NKX3-1Homeobox protein Nkx-3.1. (241 aa)
ALDH1A3Aldehyde dehydrogenase family 1 member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
NTN1Netrin-1. (604 aa)
PTCD2Pentatricopeptide repeat-containing protein 2, mitochondrial isoform X1. (384 aa)
NF1Neurofibromin isoform X1. (2873 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
BCL2L11Bcl-2-like protein 11 isoform X1. (288 aa)
LAMA5Laminin subunit alpha-5. (3687 aa)
ORAI1Calcium release-activated calcium channel protein 1. (410 aa)
AREGAmphiregulin isoform X1. (254 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
SOX10Transcription factor SOX-10. (468 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (687 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
DDX55RNA helicase. (599 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
LOC111187154Ephrin type-A receptor 2-like. (171 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
PAX8Paired box protein Pax-8. (457 aa)
ZNF330Zinc finger protein 330. (320 aa)
ASCL1Achaete-scute homolog 1. (225 aa)
FOXE1Forkhead box protein E1. (373 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (208 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PYGO2LOW QUALITY PROTEIN: pygopus homolog 2. (406 aa)
CADM1Cell adhesion molecule 1 isoform X1. (469 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
ARID5BAT-rich interactive domain-containing protein 5B isoform X1. (1184 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
ARAndrogen receptor. (893 aa)
CUNH6orf58Protein LEG1 homolog. (356 aa)
LOC111168242Protein LEG1 homolog. (216 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
CSN3Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family. (187 aa)
KDM5BLysine-specific demethylase 5B. (1539 aa)
ZBTB7BZinc finger and BTB domain-containing protein 7B. (541 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PLXNA1plexin-A1 isoform X1. (1954 aa)
PLXND1plexin-D1. (1927 aa)
CITED2Cbp/p300-interacting transactivator 2. (272 aa)
LOC111166328Nucleoside diphosphate kinase. (152 aa)
ASH1LHistone-lysine N-methyltransferase ASH1L isoform X1. (2964 aa)
CSN2Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family. (239 aa)
E2F7Transcription factor E2F7. (868 aa)
CTNNB1Catenin beta-1. (781 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
MSNMoesin isoform X1. (579 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (464 aa)
BSXBrain-specific homeobox protein homolog. (232 aa)
EDAectodysplasin-A isoform X1; Belongs to the tumor necrosis factor family. (391 aa)
DDR1Tyrosine-protein kinase receptor. (917 aa)
EAF2ELL-associated factor 2. (264 aa)
NOTCH4Neurogenic locus notch homolog protein 4 isoform X1. (1993 aa)
ELF3ETS-related transcription factor Elf-3. (372 aa)
MSX1Homeobox protein MSX-1. (303 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
SERPINE2Glia-derived nexin isoform X2; Belongs to the serpin family. (397 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1 isoform X2. (735 aa)
MKI67Proliferation marker protein Ki-67 isoform X1. (1527 aa)
NEURL1E3 ubiquitin-protein ligase NEURL1 isoform X1. (574 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
NKX2-3Homeobox protein Nkx-2.3. (366 aa)
CUL3Cullin-3 isoform X1; Belongs to the cullin family. (768 aa)
PROP1Homeobox protein prophet of Pit-1. (226 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (519 aa)
BTRCF-box/WD repeat-containing protein 1A isoform X1. (607 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
HOXD9Homeobox protein Hox-D9. (343 aa)
GDF7Growth/differentiation factor 7. (449 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (466 aa)
VDRVitamin D3 receptor isoform X1. (503 aa)
ANXA1Annexin. (346 aa)
MST1Hepatocyte growth factor-like protein isoform X1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
GPAT4Glycerol-3-phosphate acyltransferase 4. (456 aa)
HES1Transcription factor HES-1. (280 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
SIX1Homeobox protein SIX1. (284 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CLCN2Chloride channel protein 2 isoform X1. (908 aa)
EPHB3Ephrin type-B receptor 3. (997 aa)
RARGRetinoic acid receptor gamma isoform X1. (458 aa)
CCDC39Coiled-coil domain-containing protein 39. (941 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
ZBTB1Zinc finger and BTB domain-containing protein 1. (713 aa)
ZNF703Zinc finger protein 703. (585 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
CSMD1CUB and sushi domain-containing protein 1. (3564 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (544 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
SIX4Homeobox protein SIX4 isoform X1. (790 aa)
HOXD13Homeobox protein Hox-D13. (341 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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