STRINGSTRING
ANXA6 ANXA6 TCOF1 TCOF1 EDN1 EDN1 CDH2 CDH2 LOC111182889 LOC111182889 MAPK3 MAPK3 SEMA6D SEMA6D ROCK1 ROCK1 BCL2 BCL2 WNT16 WNT16 CORO1C CORO1C TBX3 TBX3 PHACTR4 PHACTR4 MAPK1 MAPK1 ALX1 ALX1 TMEM100 TMEM100 NOG NOG RET RET HAS2 HAS2 TGFBR3 TGFBR3 ISL1 ISL1 FGF10 FGF10 HEY2 HEY2 EXT1 EXT1 SEMA3C SEMA3C SEMA6B SEMA6B TCF21 TCF21 BMP2 BMP2 SNAI2 SNAI2 SEMA4D SEMA4D JAG1 JAG1 TGFBR3L TGFBR3L NRTN NRTN BMPR1A BMPR1A SEMA4A SEMA4A CITED2 CITED2 KLHL12 KLHL12 SEMA4F SEMA4F AKNA AKNA NRP1 NRP1 ALDH1A2 ALDH1A2 SMO SMO SEMA7A SEMA7A EDNRB EDNRB TGFB2 TGFB2 ENG ENG SEMA3G SEMA3G GSC GSC LRP6 LRP6 SHH SHH SEMA3B SEMA3B KBTBD8 KBTBD8 HEYL HEYL SIX2 SIX2 PEF1 PEF1 FGF8 FGF8 HMGA2 HMGA2 LOC111172488 LOC111172488 FGFR1 FGFR1 WNT5A WNT5A FAM208A FAM208A HTR2B HTR2B SEMA3F SEMA3F FN1 FN1 LOC111168867 LOC111168867 OTUD5 OTUD5 SEMA4B SEMA4B LOXL3 LOXL3 SEMA6C SEMA6C ADAM15 ADAM15 EFNA1 EFNA1 GSK3B GSK3B LOC111168869 LOC111168869 FOLR1 FOLR1 FLNA FLNA LOC111167809 LOC111167809 EPB41L5 EPB41L5 NOTCH4 NOTCH4 MSX1 MSX1 LEF1 LEF1 PHOX2B PHOX2B SEMA3D SEMA3D SEMA3E SEMA3E LOC111168870 LOC111168870 TRIM28 TRIM28 FRZB FRZB WNT10A WNT10A RADIL RADIL NRP2 NRP2 ERBB4 ERBB4 SEMA4G SEMA4G AMER1 AMER1 ACVR1 ACVR1 BMP4 BMP4 HES1 HES1 SEMA5B SEMA5B SIX1 SIX1 NOLC1 NOLC1 HIF1A HIF1A GBX2 GBX2 SFRP1 SFRP1 SEMA6A SEMA6A MEF2C MEF2C DDX5 DDX5 WNT11 WNT11 TWIST1 TWIST1 FAM172A FAM172A SOX8 SOX8 DLG5 DLG5 FAM83D FAM83D LOXL2 LOXL2 HAND2 HAND2 RDH10 RDH10 DDX17 DDX17 RFLNB RFLNB SNAI1 SNAI1 LAMA5 LAMA5 SEMA4C SEMA4C CUL7 CUL7 GDNF GDNF SOX10 SOX10 RTN4 RTN4 PPP3R1 PPP3R1 BMP7 BMP7 EDNRA EDNRA TGFBR1 TGFBR1 PPP3R2 PPP3R2 RANBP3L RANBP3L TGFB1 TGFB1 WNT2 WNT2 TBX20 TBX20 SEMA5A SEMA5A SMAD4 SMAD4 WWTR1 WWTR1 NOTCH1 NOTCH1 PDCD6 PDCD6 LOC111176792 LOC111176792
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANXA6Annexin. (673 aa)
TCOF1Treacle protein isoform X1. (1491 aa)
EDN1Endothelin-1. (202 aa)
CDH2Cadherin-2 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SEMA6Dsemaphorin-6D isoform X1; Belongs to the semaphorin family. (1073 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
TBX3T-box transcription factor TBX3 isoform X1. (745 aa)
PHACTR4Phosphatase and actin regulator. (740 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
ALX1ALX homeobox protein 1. (326 aa)
TMEM100Transmembrane protein 100. (134 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
HAS2Hyaluronan synthase 2. (552 aa)
TGFBR3Transforming growth factor beta receptor type 3 isoform X1. (851 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (880 aa)
TCF21Transcription factor 21. (179 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (863 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
TGFBR3LTransforming growth factor-beta receptor type 3-like protein isoform X1. (348 aa)
NRTNNeurturin. (197 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (762 aa)
CITED2Cbp/p300-interacting transactivator 2. (272 aa)
KLHL12Kelch-like protein 12 isoform X3. (606 aa)
SEMA4Fsemaphorin-4F isoform X1; Belongs to the semaphorin family. (789 aa)
AKNAAT-hook-containing transcription factor isoform X1. (1416 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
ALDH1A2Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (518 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (665 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ENGEndoglin. (652 aa)
SEMA3Gsemaphorin-3G isoform X1; Belongs to the semaphorin family. (773 aa)
GSCHomeobox protein goosecoid. (256 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
SEMA3Bsemaphorin-3B isoform X1; Belongs to the semaphorin family. (748 aa)
KBTBD8Kelch repeat and BTB domain-containing protein 8. (601 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (357 aa)
SIX2Homeobox protein SIX2. (296 aa)
PEF1Peflin. (290 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
HMGA2High mobility group protein HMGI-C. (109 aa)
LOC111172488Cytochrome P450 26C1; Belongs to the cytochrome P450 family. (523 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
FAM208AProtein TASOR isoform X5. (1624 aa)
HTR2B5-hydroxytryptamine receptor 2B. (490 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (785 aa)
FN1Fibronectin isoform X5. (2478 aa)
LOC111168867semaphorin-3A isoform X1. (306 aa)
OTUD5OTU domain-containing protein 5 isoform X1. (566 aa)
SEMA4Bsemaphorin-4B; Belongs to the semaphorin family. (822 aa)
LOXL3Lysyl oxidase homolog 3 isoform X1. (772 aa)
SEMA6Csemaphorin-6C isoform X5; Belongs to the semaphorin family. (966 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (866 aa)
EFNA1ephrin-A1 isoform X3; Belongs to the ephrin family. (211 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC111168869semaphorin-3A-like; Belongs to the semaphorin family. (273 aa)
FOLR1Folate receptor alpha. (251 aa)
FLNAfilamin-A isoform X1. (2647 aa)
LOC111167809ephrin-B1 isoform X1; Belongs to the ephrin family. (346 aa)
EPB41L5Band 4.1-like protein 5 isoform X1. (726 aa)
NOTCH4Neurogenic locus notch homolog protein 4 isoform X1. (1993 aa)
MSX1Homeobox protein MSX-1. (303 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (311 aa)
SEMA3Dsemaphorin-3D isoform X1; Belongs to the semaphorin family. (777 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
LOC111168870semaphorin-3A-like; Belongs to the semaphorin family. (249 aa)
TRIM28Transcription intermediary factor 1-beta. (837 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
RADILRas-associating and dilute domain-containing protein. (1072 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
SEMA4Gsemaphorin-4G isoform X1; Belongs to the semaphorin family. (843 aa)
AMER1APC membrane recruitment protein 1. (1129 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
HES1Transcription factor HES-1. (280 aa)
SEMA5Bsemaphorin-5B isoform X1. (1093 aa)
SIX1Homeobox protein SIX1. (284 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (710 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
GBX2Homeobox protein GBX-2 isoform X1. (348 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1044 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X6. (483 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (614 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TWIST1Twist-related protein 1. (205 aa)
FAM172AProtein FAM172A isoform X1. (416 aa)
SOX8Transcription factor SOX-8. (463 aa)
DLG5Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (1980 aa)
FAM83DProtein FAM83D. (560 aa)
LOXL2Lysyl oxidase homolog 2. (774 aa)
HAND2LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2. (217 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
DDX17Probable ATP-dependent RNA helicase DDX17 isoform X1; Belongs to the DEAD box helicase family. (652 aa)
RFLNBrefilin-B. (217 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
LAMA5Laminin subunit alpha-5. (3687 aa)
SEMA4Csemaphorin-4C isoform X1; Belongs to the semaphorin family. (945 aa)
CUL7Cullin-7; Belongs to the cullin family. (1693 aa)
GDNFGlial cell line-derived neurotrophic factor. (185 aa)
SOX10Transcription factor SOX-10. (468 aa)
RTN4Reticulon. (1192 aa)
PPP3R1Calcineurin subunit B type 1. (170 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (231 aa)
RANBP3LRan-binding protein 3-like isoform X1. (491 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TBX20T-box transcription factor TBX20. (449 aa)
SEMA5Asemaphorin-5A isoform X1. (1079 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
LOC111176792LOW QUALITY PROTEIN: hyaluronan synthase 2-like. (318 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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