STRINGSTRING
CORO1C CORO1C TBX3 TBX3 PHACTR4 PHACTR4 LIF LIF MAPK1 MAPK1 ALX1 ALX1 NOG NOG SLC9A1 SLC9A1 UFL1 UFL1 RET RET ZIC3 ZIC3 MSI2 MSI2 TBX2 TBX2 MTF2 MTF2 ISL1 ISL1 SETD6 SETD6 EXT1 EXT1 SEMA3C SEMA3C SEMA6B SEMA6B HOXB4 HOXB4 MED1 MED1 SNAI2 SNAI2 ESR1 ESR1 EPOP EPOP SEMA4D SEMA4D JAG1 JAG1 SOX17 SOX17 PTPRC PTPRC NRTN NRTN BMPR1A BMPR1A ZNF281 ZNF281 SEMA4A SEMA4A CITED2 CITED2 KLHL12 KLHL12 SEMA4F SEMA4F LOC111168867 LOC111168867 LOC111169295 LOC111169295 CTNNB1 CTNNB1 OTUD5 OTUD5 SEMA4B SEMA4B KIT KIT FOXO4 FOXO4 SEMA6C SEMA6C LOC111168869 LOC111168869 FOLR1 FOLR1 MYOCD MYOCD LOC111167809 LOC111167809 LOC111169240 LOC111169240 MSX1 MSX1 PHOX2B PHOX2B SEMA3D SEMA3D SEMA3E SEMA3E LOC111168870 LOC111168870 FRZB FRZB WNT10A WNT10A RADIL RADIL NRP2 NRP2 ERBB4 ERBB4 SEMA4G SEMA4G XRCC5 XRCC5 ACVR1 ACVR1 HOXD4 HOXD4 SFRP1 SFRP1 GBX2 GBX2 HIF1A HIF1A NOLC1 NOLC1 SIX1 SIX1 ECE2 ECE2 GPM6A GPM6A SEMA5B SEMA5B HES1 HES1 LMBR1L LMBR1L FN1 FN1 SEMA3F SEMA3F METTL5 METTL5 HTR2B HTR2B SETD2 SETD2 FOXA1 FOXA1 LOC111172488 LOC111172488 CDX2 CDX2 HMGA2 HMGA2 TP63 TP63 SP7 SP7 PEF1 PEF1 KBTBD8 KBTBD8 SEMA3B SEMA3B SHH SHH LOC111176725 LOC111176725 LRP6 LRP6 GSC GSC PUM1 PUM1 SEMA3G SEMA3G SOX21 SOX21 NELFB NELFB TAL1 TAL1 PHF19 PHF19 TGFB2 TGFB2 EDNRB EDNRB DMRTA2 DMRTA2 SEMA7A SEMA7A SMO SMO ALDH1A2 ALDH1A2 SRF SRF BATF BATF NRP1 NRP1 LOC111176553 LOC111176553 RUNX2 RUNX2 PDCD6 PDCD6 NOTCH1 NOTCH1 EZH2 EZH2 ITGB1 ITGB1 SMAD4 SMAD4 SEMA5A SEMA5A ERCC2 ERCC2 ZFP36 ZFP36 CDK6 CDK6 FZD1 FZD1 JARID2 JARID2 BCL2 BCL2 GREM1 GREM1 GATA6 GATA6 SEMA6D SEMA6D ELL3 ELL3 MAPK3 MAPK3 LOC111182889 LOC111182889 HOXA7 HOXA7 WNT3 WNT3 CDH2 CDH2 EDN1 EDN1 TCOF1 TCOF1 ANXA6 ANXA6 SHC4 SHC4 SEMA6A SEMA6A MEF2C MEF2C TWIST1 TWIST1 FAM172A FAM172A SOX8 SOX8 HAND2 HAND2 RDH10 RDH10 SH2B3 SH2B3 LAMA5 LAMA5 SEMA4C SEMA4C PSMD11 PSMD11 BBS12 BBS12 GDNF GDNF PHF5A PHF5A SOX10 SOX10 EDNRA EDNRA SOX18 SOX18 SFRP2 SFRP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
TBX3T-box transcription factor TBX3 isoform X1. (745 aa)
PHACTR4Phosphatase and actin regulator. (740 aa)
LIFLeukemia inhibitory factor. (202 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
ALX1ALX homeobox protein 1. (326 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
UFL1E3 UFM1-protein ligase 1. (791 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
ZIC3Zinc finger protein ZIC 3 isoform X1. (464 aa)
MSI2RNA-binding protein Musashi homolog 2 isoform X1. (354 aa)
TBX2T-box transcription factor TBX2. (713 aa)
MTF2Metal-response element-binding transcription factor 2 isoform X1. (593 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
SETD6N-lysine methyltransferase SETD6 isoform X7. (565 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (880 aa)
HOXB4Homeobox protein Hox-B4. (251 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
EPOPElongin BC and Polycomb repressive complex 2-associated protein. (379 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (863 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1221 aa)
SOX17Transcription factor SOX-17. (408 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
NRTNNeurturin. (197 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZNF281Zinc finger protein 281. (870 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (762 aa)
CITED2Cbp/p300-interacting transactivator 2. (272 aa)
KLHL12Kelch-like protein 12 isoform X3. (606 aa)
SEMA4Fsemaphorin-4F isoform X1; Belongs to the semaphorin family. (789 aa)
LOC111168867semaphorin-3A isoform X1. (306 aa)
LOC111169295RE1-silencing transcription factor-like isoform X1. (981 aa)
CTNNB1Catenin beta-1. (781 aa)
OTUD5OTU domain-containing protein 5 isoform X1. (566 aa)
SEMA4Bsemaphorin-4B; Belongs to the semaphorin family. (822 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
FOXO4Forkhead box protein O4. (512 aa)
SEMA6Csemaphorin-6C isoform X5; Belongs to the semaphorin family. (966 aa)
LOC111168869semaphorin-3A-like; Belongs to the semaphorin family. (273 aa)
FOLR1Folate receptor alpha. (251 aa)
MYOCDMyocardin isoform X1. (985 aa)
LOC111167809ephrin-B1 isoform X1; Belongs to the ephrin family. (346 aa)
LOC111169240RE1-silencing transcription factor-like isoform X2. (976 aa)
MSX1Homeobox protein MSX-1. (303 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (311 aa)
SEMA3Dsemaphorin-3D isoform X1; Belongs to the semaphorin family. (777 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
LOC111168870semaphorin-3A-like; Belongs to the semaphorin family. (249 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
RADILRas-associating and dilute domain-containing protein. (1072 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
SEMA4Gsemaphorin-4G isoform X1; Belongs to the semaphorin family. (843 aa)
XRCC5X-ray repair cross-complementing protein 5. (733 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
HOXD4Homeobox protein Hox-D4. (255 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
GBX2Homeobox protein GBX-2 isoform X1. (348 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X1. (823 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (710 aa)
SIX1Homeobox protein SIX1. (284 aa)
ECE2Endothelin-converting enzyme 2 isoform X6. (912 aa)
GPM6ANeuronal membrane glycoprotein M6-a isoform X1. (293 aa)
SEMA5Bsemaphorin-5B isoform X1. (1093 aa)
HES1Transcription factor HES-1. (280 aa)
LMBR1LProtein LMBR1L isoform X1; Belongs to the LIMR family. (521 aa)
FN1Fibronectin isoform X5. (2478 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (785 aa)
METTL5Methyltransferase-like protein 5 isoform X1. (209 aa)
HTR2B5-hydroxytryptamine receptor 2B. (490 aa)
SETD2Histone-lysine N-methyltransferase SETD2 isoform X1. (2570 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (466 aa)
LOC111172488Cytochrome P450 26C1; Belongs to the cytochrome P450 family. (523 aa)
CDX2Homeobox protein CDX-2. (303 aa)
HMGA2High mobility group protein HMGI-C. (109 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SP7Transcription factor Sp7. (431 aa)
PEF1Peflin. (290 aa)
KBTBD8Kelch repeat and BTB domain-containing protein 8. (601 aa)
SEMA3Bsemaphorin-3B isoform X1; Belongs to the semaphorin family. (748 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
LOC111176725Homeobox protein NANOG-like. (245 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
GSCHomeobox protein goosecoid. (256 aa)
PUM1Pumilio homolog 1 isoform X1. (1193 aa)
SEMA3Gsemaphorin-3G isoform X1; Belongs to the semaphorin family. (773 aa)
SOX21Transcription factor SOX-21. (276 aa)
NELFBNegative elongation factor B isoform X2. (580 aa)
TAL1T-cell acute lymphocytic leukemia protein 1 isoform X1. (328 aa)
PHF19PHD finger protein 19 isoform X1. (601 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
DMRTA2Doublesex- and mab-3-related transcription factor A2 isoform X1. (555 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (665 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
ALDH1A2Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (518 aa)
SRFSerum response factor isoform X2. (535 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
LOC111176553Homeobox protein NANOG-like. (306 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (524 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (747 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SEMA5Asemaphorin-5A isoform X1. (1079 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit isoform X1. (823 aa)
ZFP36mRNA decay activator protein ZFP36. (325 aa)
CDK6Cyclin-dependent kinase 6 isoform X1; Belongs to the protein kinase superfamily. (326 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
JARID2Protein Jumonji isoform X1. (1235 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
GREM1Gremlin. (184 aa)
GATA6Transcription factor GATA-6. (592 aa)
SEMA6Dsemaphorin-6D isoform X1; Belongs to the semaphorin family. (1073 aa)
ELL3RNA polymerase II elongation factor ELL3 isoform X2. (397 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
HOXA7Homeobox protein Hox-A7. (233 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
CDH2Cadherin-2 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
EDN1Endothelin-1. (202 aa)
TCOF1Treacle protein isoform X1. (1491 aa)
ANXA6Annexin. (673 aa)
SHC4SHC-transforming protein 4. (630 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1044 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X6. (483 aa)
TWIST1Twist-related protein 1. (205 aa)
FAM172AProtein FAM172A isoform X1. (416 aa)
SOX8Transcription factor SOX-8. (463 aa)
HAND2LOW QUALITY PROTEIN: heart- and neural crest derivatives-expressed protein 2. (217 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
SH2B3SH2B adapter protein 3 isoform X1. (618 aa)
LAMA5Laminin subunit alpha-5. (3687 aa)
SEMA4Csemaphorin-4C isoform X1; Belongs to the semaphorin family. (945 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (422 aa)
BBS12Bardet-Biedl syndrome 12 protein. (715 aa)
GDNFGlial cell line-derived neurotrophic factor. (185 aa)
PHF5APHD finger-like domain-containing protein 5A isoform X1. (110 aa)
SOX10Transcription factor SOX-10. (468 aa)
EDNRAEndothelin-1 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SOX18Transcription factor SOX-18. (390 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (12%) [HD]