STRINGSTRING
HNF1A HNF1A CLDN5 CLDN5 AQP7 AQP7 ACACB ACACB GRHL3 GRHL3 UMOD UMOD AQP3 AQP3 SFN SFN KDF1 KDF1 USP45 USP45 TFF3 TFF3 CIDEA CIDEA HAS2 HAS2 GRHL1 GRHL1 TJP1 TJP1 NAPEPLD NAPEPLD CTSH CTSH ADD1 ADD1 ACACA ACACA NOD2 NOD2 TFF1 TFF1 NR1D2 NR1D2 SCX SCX ABCA4 ABCA4 IRX3 IRX3 BBS2 BBS2 EXT1 EXT1 VSIG1 VSIG1 USH1C USH1C POC1B POC1B MKS1 MKS1 RAB3D RAB3D CTGF CTGF ACP5 ACP5 FTO FTO LOC111165064 LOC111165064 NR1D1 NR1D1 STAT3 STAT3 NXNL1 NXNL1 COMP COMP KLHL10 KLHL10 HOMER2 HOMER2 NKIRAS2 NKIRAS2 NKIRAS1 NKIRAS1 DRD2 DRD2 IL7 IL7 TMEM79 TMEM79 BBS10 BBS10 MBP MBP FMO4 FMO4 IL18 IL18 FMO1 FMO1 ACER1 ACER1 SLC35D3 SLC35D3 FMO3 FMO3 ILDR2 ILDR2 PTH PTH FLCN FLCN RP1 RP1 LOC111167902 LOC111167902 NXNL2 NXNL2 CRTC1 CRTC1 SASH3 SASH3 TJP3 TJP3 XIAP XIAP ATP6V1B1 ATP6V1B1 MLLT6 MLLT6 HCRT HCRT LOC111167328 LOC111167328 CTNNB1 CTNNB1 SQSTM1 SQSTM1 KMT2A KMT2A NMU NMU RRP8 RRP8 VSTM4 VSTM4 CRTC3 CRTC3 DLL1 DLL1 CTSK CTSK ERCC6 ERCC6 GATA1 GATA1 MRAP2 MRAP2 IQCB1 IQCB1 TUB TUB PIWIL4 PIWIL4 KIAA1211 KIAA1211 YAP1 YAP1 CYTL1 CYTL1 CDHR1 CDHR1 MUC13 MUC13 GPR55 GPR55 SLC11A1 SLC11A1 NOX3 NOX3 TPP1 TPP1 COL3A1 COL3A1 NANOS1 NANOS1 SUV39H1 SUV39H1 KDR KDR IHH IHH ZNF830 ZNF830 NDN NDN LOC111169978 LOC111169978 MBL2 MBL2 PPARGC1A PPARGC1A PROM1 PROM1 LDB1 LDB1 LIPA LIPA STK11 STK11 CLDN1 CLDN1 STK39 STK39 PASK PASK ILDR1 ILDR1 AQP2 AQP2 TNS2 TNS2 ADRB1 ADRB1 PIK3CA PIK3CA LDB2 LDB2 BAP1 BAP1 PRLH PRLH EPAS1 EPAS1 COL2A1 COL2A1 SH3GL2 SH3GL2 TLR9 TLR9 ADRB3 ADRB3 RBP4 RBP4 TNFSF11 TNFSF11 CXADR CXADR PTH1R PTH1R TP63 TP63 NCDN NCDN EDN2 EDN2 OMA1 OMA1 MFSD2A MFSD2A EIF4G1 EIF4G1 KRAS KRAS SLC11A2 SLC11A2 AKAP11 AKAP11 HYAL2 HYAL2 CRB2 CRB2 MTF1 MTF1 TRIM32 TRIM32 ALDH1A1 ALDH1A1 USH2A USH2A TJP2 TJP2 AKT3 AKT3 FH FH BBS4 BBS4 SPATA7 SPATA7 UGCG UGCG SCNN1A SCNN1A SLC2A1 SLC2A1 SMO SMO CRB1 CRB1 TFAP2B TFAP2B IL17A IL17A SRF SRF LEPR LEPR LOC111176792 LOC111176792 STRAP STRAP RPE65 RPE65 SLC39A8 SLC39A8 LOC111176900 LOC111176900 NOTCH1 NOTCH1 DBH DBH MET MET WWTR1 WWTR1 BTBD9 BTBD9 WHRN WHRN CDH3 CDH3 CLRN1 CLRN1 IL20RB IL20RB CFTR CFTR SNX10 SNX10 SGIP1 SGIP1 LPCAT1 LPCAT1 COL11A2 COL11A2 TULP1 TULP1 ADGRF5 ADGRF5 DRAM2 DRAM2 TNFRSF11A TNFRSF11A WFS1 WFS1 TGFB1 TGFB1 BMP6 BMP6 FA2H FA2H NPHP3 NPHP3 LTK LTK AQP1 AQP1 AQP4 AQP4 BCL2 BCL2 LSR LSR TRAF6 TRAF6 GCNT2 GCNT2 CSF1 CSF1 EGR1 EGR1 MEX3C MEX3C PPP1R13L PPP1R13L RCN3 RCN3 LOC111182889 LOC111182889 HOXA13 HOXA13 HAMP HAMP LOC111181354 LOC111181354 MAK MAK SLC28A2 SLC28A2 LRRC45 LRRC45 LOC111183561 LOC111183561 USH1G USH1G SIRT1 SIRT1 SCNN1G SCNN1G LOC111183400 LOC111183400 CORO1A CORO1A SCNN1B SCNN1B BPIFA1 BPIFA1 BBS1 BBS1 CD7 CD7 ADRB2 ADRB2 SRC SRC ARRDC3 ARRDC3 ADGRV1 ADGRV1 SFTPD SFTPD PBLD PBLD CDH23 CDH23 TCIRG1 TCIRG1 PRCP PRCP NOX4 NOX4 TSKU TSKU ATP1B2 ATP1B2 EXT2 EXT2 ALOX12 ALOX12 TP53INP2 TP53INP2 CLCN3 CLCN3 PRDM14 PRDM14 TRPM2 TRPM2 PM20D1 PM20D1 AIPL1 AIPL1 TRPV1 TRPV1 HOMER1 HOMER1 CCDC154 CCDC154 P2RX7 P2RX7 F2R F2R PTK2B PTK2B LRRK1 LRRK1 ACADVL ACADVL IL1A IL1A BBS12 BBS12 CROCC CROCC VPS54 VPS54 PTPN11 PTPN11 NPHP4 NPHP4 STARD7 STARD7 TRPV4 TRPV4 IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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HNF1AHepatocyte nuclear factor 1-alpha. (632 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
AQP7LOW QUALITY PROTEIN: aquaporin-7; Belongs to the MIP/aquaporin (TC 1.A.8) family. (330 aa)
ACACBacetyl-CoA carboxylase 2 isoform X1. (2456 aa)
GRHL3Grainyhead-like protein 3 homolog. (602 aa)
UMODUromodulin. (643 aa)
AQP3Aquaporin-3; Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
USP45Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (816 aa)
TFF3Trefoil factor 3. (80 aa)
CIDEACell death activator CIDE-A. (219 aa)
HAS2Hyaluronan synthase 2. (552 aa)
GRHL1Grainyhead-like protein 1 homolog. (630 aa)
TJP1Tight junction protein ZO-1 isoform X1; Belongs to the MAGUK family. (1914 aa)
NAPEPLDN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1. (478 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (335 aa)
ADD1Alpha-adducin isoform X1. (785 aa)
ACACAacetyl-CoA carboxylase 1 isoform X1. (2383 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
TFF1Trefoil factor 1. (127 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2 isoform X1. (575 aa)
SCXBasic helix-loop-helix transcription factor scleraxis isoform X2. (203 aa)
ABCA4Retinal-specific ATP-binding cassette transporter. (2205 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (502 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
VSIG1V-set and immunoglobulin domain-containing protein 1. (378 aa)
USH1CHarmonin isoform X1. (741 aa)
POC1BPOC1 centriolar protein homolog B isoform X1. (478 aa)
MKS1Meckel syndrome type 1 protein isoform X3. (618 aa)
RAB3DRas-related protein Rab-3D. (219 aa)
CTGFConnective tissue growth factor isoform X1. (349 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (349 aa)
FTOAlpha-ketoglutarate-dependent dioxygenase FTO isoform X1. (505 aa)
LOC111165064Plectin isoform X1. (4685 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
NXNL1Nucleoredoxin-like protein 1. (218 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
KLHL10LOW QUALITY PROTEIN: kelch-like protein 10. (614 aa)
HOMER2Homer protein homolog 2 isoform X1. (343 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1. (191 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1. (192 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
IL7Interleukin-7 isoform X1. (226 aa)
TMEM79Transmembrane protein 79. (395 aa)
BBS10Bardet-Biedl syndrome 10 protein; Belongs to the TCP-1 chaperonin family. (721 aa)
MBPMyelin basic protein isoform X1. (326 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (557 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
FMO1Dimethylaniline monooxygenase [N-oxide-forming]. (537 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
SLC35D3Solute carrier family 35 member D3. (422 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
ILDR2Immunoglobulin-like domain-containing receptor 2. (639 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
FLCNFolliculin isoform X1. (591 aa)
RP1Oxygen-regulated protein 1. (2137 aa)
LOC111167902Cytochrome P450 26B1 isoform X1; Belongs to the cytochrome P450 family. (512 aa)
NXNL2LOW QUALITY PROTEIN: nucleoredoxin-like protein 2. (156 aa)
CRTC1CREB-regulated transcription coactivator 1 isoform X1. (655 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
TJP3Tight junction protein ZO-3 isoform X1; Belongs to the MAGUK family. (922 aa)
XIAPE3 ubiquitin-protein ligase XIAP isoform X1. (497 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
MLLT6Protein AF-17 isoform X1. (1083 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
LOC111167328Dimethylaniline monooxygenase [N-oxide-forming]. (537 aa)
CTNNB1Catenin beta-1. (781 aa)
SQSTM1Sequestosome-1. (440 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4012 aa)
NMUneuromedin-U. (89 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (482 aa)
VSTM4V-set and transmembrane domain-containing protein 4 isoform X1. (353 aa)
CRTC3CREB-regulated transcription coactivator 3 isoform X1. (619 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (799 aa)
CTSKCathepsin K isoform X1; Belongs to the peptidase C1 family. (358 aa)
ERCC6DNA excision repair protein ERCC-6. (1485 aa)
GATA1Erythroid transcription factor isoform X1. (426 aa)
MRAP2Melanocortin-2 receptor accessory protein 2. (206 aa)
IQCB1IQ calmodulin-binding motif-containing protein 1 isoform X1. (598 aa)
TUBTubby-like protein; Belongs to the TUB family. (511 aa)
PIWIL4Piwi-like protein 4; Belongs to the argonaute family. (852 aa)
KIAA1211Uncharacterized protein KIAA1211 homolog isoform X1. (1277 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (511 aa)
CYTL1Cytokine-like protein 1. (162 aa)
CDHR1Cadherin-related family member 1 isoform X1. (930 aa)
MUC13Mucin-13. (397 aa)
GPR55G-protein coupled receptor 55 isoform X1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
SLC11A1Natural resistance-associated macrophage protein 1 isoform X1. (546 aa)
NOX3NADPH oxidase 3. (568 aa)
TPP1Tripeptidyl-peptidase 1. (572 aa)
COL3A1Collagen alpha-1(III) chain. (1464 aa)
NANOS1Nanos homolog 1; Belongs to the nanos family. (288 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (419 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
ZNF830Zinc finger protein 830. (380 aa)
NDNNecdin. (325 aa)
LOC111169978Von Hippel-Lindau disease tumor suppressor. (166 aa)
MBL2LOW QUALITY PROTEIN: mannose-binding protein C. (244 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
PROM1Prominin-1 isoform X1. (887 aa)
LDB1LIM domain-binding protein 1 isoform X3. (436 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
STK11Serine/threonine-protein kinase STK11 isoform X1. (544 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
STK39STE20/SPS1-related proline-alanine-rich protein kinase isoform X1. (539 aa)
PASKPAS domain-containing serine/threonine-protein kinase. (1325 aa)
ILDR1Immunoglobulin-like domain-containing receptor 1. (459 aa)
AQP2Aquaporin-2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (309 aa)
TNS2Tensin-2 isoform X2. (1415 aa)
ADRB1Beta-1 adrenergic receptor. (470 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LDB2LIM domain-binding protein 2 isoform X1. (373 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
PRLHProlactin-releasing peptide. (79 aa)
EPAS1Endothelial PAS domain-containing protein 1 isoform X1. (866 aa)
COL2A1Collagen alpha-1(II) chain. (1487 aa)
SH3GL2endophilin-A1. (352 aa)
TLR9LOW QUALITY PROTEIN: toll-like receptor 9. (1323 aa)
ADRB3LOW QUALITY PROTEIN: beta-3 adrenergic receptor. (391 aa)
RBP4Retinol-binding protein 4 isoform X1; Belongs to the calycin superfamily. Lipocalin family. (119 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
CXADRCoxsackievirus and adenovirus receptor isoform X1. (365 aa)
PTH1RParathyroid hormone/parathyroid hormone-related peptide receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (602 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
NCDNNeurochondrin isoform X1. (729 aa)
EDN2Endothelin-2. (147 aa)
OMA1Metalloendopeptidase OMA1, mitochondrial isoform X1. (543 aa)
MFSD2ASodium-dependent lysophosphatidylcholine symporter 1 isoform X1. (565 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1 isoform X1. (1608 aa)
KRASGTPase KRas. (188 aa)
SLC11A2Natural resistance-associated macrophage protein 2 isoform X1. (579 aa)
AKAP11A-kinase anchor protein 11 isoform X1. (1909 aa)
HYAL2Hyaluronidase. (476 aa)
CRB2Protein crumbs homolog 2. (1281 aa)
MTF1Metal regulatory transcription factor 1 isoform X1. (751 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32 isoform X1. (699 aa)
ALDH1A1Retinal dehydrogenase 1; Belongs to the aldehyde dehydrogenase family. (501 aa)
USH2AUsherin. (5204 aa)
TJP2Tight junction protein ZO-2 isoform X2; Belongs to the MAGUK family. (1187 aa)
AKT3Non-specific serine/threonine protein kinase. (541 aa)
FHFumarate hydratase, mitochondrial. (510 aa)
BBS4Bardet-Biedl syndrome 4 protein isoform X1. (528 aa)
SPATA7Spermatogenesis-associated protein 7 isoform X1. (600 aa)
UGCGCeramide glucosyltransferase. (394 aa)
SCNN1AAmiloride-sensitive sodium channel subunit alpha; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (648 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
CRB1Protein crumbs homolog 1 isoform X1. (1457 aa)
TFAP2BTranscription factor AP-2-beta isoform X1. (467 aa)
IL17Ainterleukin-17A. (155 aa)
SRFSerum response factor isoform X2. (535 aa)
LEPRLeptin receptor isoform X1. (917 aa)
LOC111176792LOW QUALITY PROTEIN: hyaluronan synthase 2-like. (318 aa)
STRAPSerine-threonine kinase receptor-associated protein isoform X1. (350 aa)
RPE65Retinoid isomerohydrolase. (533 aa)
SLC39A8Zinc transporter ZIP8 isoform X1. (461 aa)
LOC111176900GTPase IMAP family member 5-like isoform X1. (332 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
DBHDopamine beta-hydroxylase. (610 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
BTBD9BTB/POZ domain-containing protein 9 isoform X1. (637 aa)
WHRNWhirlin isoform X1. (919 aa)
CDH3Cadherin-3 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (834 aa)
CLRN1Clarin-1 isoform X2. (246 aa)
IL20RBInterleukin-20 receptor subunit beta isoform X1. (342 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1482 aa)
SNX10Sorting nexin-10 isoform X1. (201 aa)
SGIP1SH3-containing GRB2-like protein 3-interacting protein 1 isoform X1. (854 aa)
LPCAT1Lysophosphatidylcholine acyltransferase 1 isoform X1. (534 aa)
COL11A2LOW QUALITY PROTEIN: collagen alpha-2(XI) chain. (1736 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (537 aa)
ADGRF5Adhesion G protein-coupled receptor F5 isoform X1; Belongs to the G-protein coupled receptor 2 family. (1408 aa)
DRAM2DNA damage-regulated autophagy modulator protein 2 isoform X1. (266 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A isoform X1. (551 aa)
WFS1Wolframin. (889 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (396 aa)
NPHP3Nephrocystin-3 isoform X1. (1345 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (922 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
AQP4Aquaporin-4 isoform X1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (338 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
LSRLipolysis-stimulated lipoprotein receptor isoform X3. (634 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
GCNT2N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform X1. (419 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
MEX3CRNA-binding E3 ubiquitin-protein ligase MEX3C. (653 aa)
PPP1R13LrelA-associated inhibitor isoform X1. (818 aa)
RCN3Reticulocalbin-3 isoform X1. (360 aa)
LOC111182889LOW QUALITY PROTEIN: transcription factor SOX-9-like. (510 aa)
HOXA13Homeobox protein Hox-A13. (387 aa)
HAMPHepcidin isoform X2. (108 aa)
LOC111181354N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase-like. (321 aa)
MAKSerine/threonine-protein kinase MAK. (648 aa)
SLC28A2Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (658 aa)
LRRC45Leucine-rich repeat-containing protein 45 isoform X1. (703 aa)
LOC111183561Mannose-binding protein A-like isoform X1. (265 aa)
USH1GUsher syndrome type-1G protein isoform X1. (461 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
SCNN1GAmiloride-sensitive sodium channel subunit gamma; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (651 aa)
LOC111183400CREB-regulated transcription coactivator 3-like. (208 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
SCNN1BAmiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (641 aa)
BPIFA1BPI fold-containing family A member 1. (263 aa)
BBS1Bardet-Biedl syndrome 1 protein. (593 aa)
CD7T-cell antigen CD7. (208 aa)
ADRB2Beta-2 adrenergic receptor isoform X1. (400 aa)
SRCTyrosine-protein kinase. (562 aa)
ARRDC3Arrestin domain-containing protein 3 isoform X1. (414 aa)
ADGRV1G-protein coupled receptor 98 isoform X1; Belongs to the G-protein coupled receptor 2 family. (6312 aa)
SFTPDPulmonary surfactant-associated protein D. (375 aa)
PBLDPhenazine biosynthesis-like domain-containing protein. (288 aa)
CDH23Cadherin-23 isoform X1. (3358 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (873 aa)
PRCPLysosomal Pro-X carboxypeptidase. (499 aa)
NOX4NADPH oxidase 4. (530 aa)
TSKUTsukushin isoform X1. (367 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
EXT2Exostosin-2 isoform X1; Belongs to the glycosyltransferase 47 family. (718 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S-type. (663 aa)
TP53INP2Tumor protein p53-inducible nuclear protein 2 isoform X1. (263 aa)
CLCN3Chloride channel protein. (866 aa)
PRDM14PR domain zinc finger protein 14. (571 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1497 aa)
PM20D1N-fatty-acyl-amino acid synthase/hydrolase PM20D1. (505 aa)
AIPL1Aryl-hydrocarbon-interacting protein-like 1. (328 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. (864 aa)
HOMER1Homer protein homolog 1 isoform X1. (354 aa)
CCDC154LOW QUALITY PROTEIN: coiled-coil domain-containing protein 154. (697 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1. (2015 aa)
ACADVLVery long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1. (655 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
BBS12Bardet-Biedl syndrome 12 protein. (715 aa)
CROCCRootletin isoform X1. (2013 aa)
VPS54Vacuolar protein sorting-associated protein 54 isoform X1. (1001 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
NPHP4Nephrocystin-4 isoform X1. (1430 aa)
STARD7stAR-related lipid transfer protein 7, mitochondrial. (382 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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