STRINGSTRING
CCL19 CCL19 PLA2G2F PLA2G2F TWSG1 TWSG1 EPHB2 EPHB2 MYD88 MYD88 GLMN GLMN PLA2G2D PLA2G2D CD40LG CD40LG FGF10 FGF10 TYK2 TYK2 CD320 CD320 IKZF3 IKZF3 LOC111166170 LOC111166170 STAT5A STAT5A LOC111166483 LOC111166483 DHPS DHPS PKN1 PKN1 LOC111166997 LOC111166997 IL27RA IL27RA IL12RB1 IL12RB1 RASAL3 RASAL3 IL7 IL7 LYN LYN PAWR PAWR TMIGD2 TMIGD2 IL18 IL18 ERBB2 ERBB2 CRTAM CRTAM SASH3 SASH3 PTPRC PTPRC ATM ATM TNFSF9 TNFSF9 ZBTB7B ZBTB7B SLAMF1 SLAMF1 SPTA1 SPTA1 CTNNB1 CTNNB1 WNT3A WNT3A VSIG4 VSIG4 FOXP3 FOXP3 CD40 CD40 CD80 CD80 TNFSF18 TNFSF18 SYK SYK TNFRSF13B TNFRSF13B LOC111167809 LOC111167809 IL12B IL12B ZNF335 ZNF335 AIF1 AIF1 SOX11 SOX11 CARD11 CARD11 AGER AGER CD86 CD86 BST1 BST1 TNFSF4 TNFSF4 RC3H1 RC3H1 MAD1L1 MAD1L1 CD28 CD28 DLG1 DLG1 GPAM GPAM IHH IHH MARCH7 MARCH7 BCL6 BCL6 BMP4 BMP4 CTLA4 CTLA4 IGFBP2 IGFBP2 TFRC TFRC INPP5D INPP5D SOS2 SOS2 CD38 CD38 NCKAP1L NCKAP1L HES1 HES1 ANXA1 ANXA1 ARG2 ARG2 SOS1 SOS1 TLR9 TLR9 SLC7A1 SLC7A1 CD274 CD274 LGALS3 LGALS3 IRS2 IRS2 LOC111176429 LOC111176429 IDO1 IDO1 LOC111175407 LOC111175407 PDCD1LG2 PDCD1LG2 SHH SHH IL12A IL12A PTPN6 PTPN6 BMI1 BMI1 TNFSF13B TNFSF13B LOC111178657 LOC111178657 LOC111178664 LOC111178664 BTK BTK LRRC1 LRRC1 HMCN2 HMCN2 PRKCQ PRKCQ NCK1 NCK1 CDKN1A CDKN1A IL20RB IL20RB IL12RB2 IL12RB2 VAV3 VAV3 CD22 CD22 BTNL2 BTNL2 TGFB1 TGFB1 IL4I1 IL4I1 TNFRSF21 TNFRSF21 PPP3CA PPP3CA BCL2 BCL2 TRAF6 TRAF6 PYCARD PYCARD PTPN22 PTPN22 IRF1 IRF1 GPNMB GPNMB FOXJ1 FOXJ1 ZP3 ZP3 SIGLEC10 SIGLEC10 LEP LEP TYROBP TYROBP LOC111182867 LOC111182867 CD81 CD81 CD74 CD74 IL27 IL27 CLCF1 CLCF1 CORO1A CORO1A IGF2 IGF2 FADD FADD MZB1 MZB1 MEF2C MEF2C PRKAR1A PRKAR1A RPS3 RPS3 NDFIP1 NDFIP1 VSIR VSIR DLG5 DLG5 TSPAN32 TSPAN32 BLK BLK IL10 IL10 RASSF5 RASSF5 LRRC32 LRRC32 DLG2 DLG2 CD6 CD6 CCDC88B CCDC88B MAPK8IP1 MAPK8IP1 CBLB CBLB ADA ADA ITCH ITCH SH3RF1 SH3RF1 RAC2 RAC2 TNFRSF9 TNFRSF9 TNFRSF13C TNFRSF13C IL6ST IL6ST LGALS9 LGALS9 CEBPB CEBPB ATAD5 ATAD5 TNFRSF1B TNFRSF1B IL21 IL21 HHLA2 HHLA2 NCK2 NCK2 PELI1 PELI1 TMEM131L TMEM131L NFATC2 NFATC2 IGF1 IGF1 IL15 IL15 Ob Ob IL1B IL1B AHR AHR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCL19C-C motif chemokine. (159 aa)
PLA2G2FPhospholipase A(2). (300 aa)
TWSG1Twisted gastrulation protein homolog 1. (223 aa)
EPHB2Ephrin type-B receptor 2 isoform X1. (987 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
GLMNGlomulin. (592 aa)
PLA2G2DPhospholipase A(2). (161 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
CD320CD320 antigen. (265 aa)
IKZF3Zinc finger protein Aiolos isoform X1. (509 aa)
LOC111166170C-type lectin domain family 4 member G-like isoform X1. (313 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
DHPSDeoxyhypusine synthase. (369 aa)
PKN1Serine/threonine-protein kinase N1 isoform X1. (950 aa)
LOC111166997Fc receptor-like protein 3 isoform X2. (726 aa)
IL27RAInterleukin-27 receptor subunit alpha isoform X1. (656 aa)
IL12RB1Interleukin-12 receptor subunit beta-1 isoform X1. (726 aa)
RASAL3RAS protein activator like-3 isoform X1. (1035 aa)
IL7Interleukin-7 isoform X1. (226 aa)
LYNTyrosine-protein kinase. (518 aa)
PAWRPRKC apoptosis WT1 regulator protein. (345 aa)
TMIGD2Transmembrane and immunoglobulin domain-containing protein 2. (231 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
CRTAMCytotoxic and regulatory T-cell molecule isoform X1. (391 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
TNFSF9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (252 aa)
ZBTB7BZinc finger and BTB domain-containing protein 7B. (541 aa)
SLAMF1Signaling lymphocytic activation molecule isoform X1. (378 aa)
SPTA1Spectrin alpha chain, erythrocytic 1 isoform X1. (2417 aa)
CTNNB1Catenin beta-1. (781 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
VSIG4V-set and immunoglobulin domain-containing protein 4. (399 aa)
FOXP3Forkhead box protein P3. (431 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (284 aa)
CD80T-lymphocyte activation antigen CD80 isoform X1. (295 aa)
TNFSF18Tumor necrosis factor ligand superfamily member 18. (178 aa)
SYKTyrosine-protein kinase. (626 aa)
TNFRSF13BTumor necrosis factor receptor superfamily member 13B isoform X1. (284 aa)
LOC111167809ephrin-B1 isoform X1; Belongs to the ephrin family. (346 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
ZNF335Zinc finger protein 335 isoform X1. (1346 aa)
AIF1Allograft inflammatory factor 1 isoform X1. (162 aa)
SOX11Transcription factor SOX. (454 aa)
CARD11Caspase recruitment domain-containing protein 11 isoform X1. (1154 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (344 aa)
BST1ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1. (320 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (182 aa)
RC3H1Roquin-1 isoform X1. (1135 aa)
MAD1L1Mitotic spindle assembly checkpoint protein MAD1 isoform X2. (735 aa)
CD28T-cell-specific surface glycoprotein CD28. (265 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (877 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
MARCH7E3 ubiquitin-protein ligase MARCH7 isoform X1. (717 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
BMP4Bone morphogenetic protein 4 isoform X2. (408 aa)
CTLA4Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
IGFBP2Insulin-like growth factor-binding protein 2 isoform X1. (320 aa)
TFRCTransferrin receptor protein 1 isoform X1. (772 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
CD38ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1. (307 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1156 aa)
HES1Transcription factor HES-1. (280 aa)
ANXA1Annexin. (346 aa)
ARG2Arginase. (354 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
TLR9LOW QUALITY PROTEIN: toll-like receptor 9. (1323 aa)
SLC7A1High affinity cationic amino acid transporter 1. (629 aa)
CD274Programmed cell death 1 ligand 1 isoform X2. (312 aa)
LGALS3Galectin. (256 aa)
IRS2Insulin receptor substrate 2. (1347 aa)
LOC111176429G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (360 aa)
IDO1Indoleamine 2,3-dioxygenase 1 isoform X1. (410 aa)
LOC111175407Amine oxidase. (524 aa)
PDCD1LG2Programmed cell death 1 ligand 2 isoform X1. (337 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
BMI1Polycomb complex protein BMI-1. (326 aa)
TNFSF13BTumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (283 aa)
LOC111178657Leucine-rich repeat-containing protein 1-like isoform X1. (174 aa)
LOC111178664HLA class II histocompatibility antigen, DM beta chain isoform X1. (263 aa)
BTKTyrosine-protein kinase. (687 aa)
LRRC1Leucine-rich repeat-containing protein 1. (395 aa)
HMCN2Hemicentin-2 isoform X2. (5072 aa)
PRKCQProtein kinase C. (665 aa)
NCK1Cytoplasmic protein. (377 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
IL20RBInterleukin-20 receptor subunit beta isoform X1. (342 aa)
IL12RB2Interleukin-12 receptor subunit beta-2 isoform X1. (861 aa)
VAV3Guanine nucleotide exchange factor VAV3. (954 aa)
CD22B-cell receptor CD22. (843 aa)
BTNL2Butyrophilin-like protein 2. (454 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
IL4I1L-amino-acid oxidase isoform X1. (653 aa)
TNFRSF21Tumor necrosis factor receptor superfamily member 21 isoform X3. (701 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
BCL2Apoptosis regulator Bcl-2. (233 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
IRF1Interferon regulatory factor. (322 aa)
GPNMBTransmembrane glycoprotein NMB. (553 aa)
FOXJ1Forkhead box protein J1. (422 aa)
ZP3Zona pellucida sperm-binding protein 3. (421 aa)
SIGLEC10Sialic acid-binding Ig-like lectin 10 isoform X1. (706 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
TYROBPTYRO protein tyrosine kinase-binding protein isoform X1. (126 aa)
LOC111182867CMRF35-like molecule 8 isoform X1. (313 aa)
CD81Tetraspanin. (236 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
IL27Interleukin-27 subunit alpha. (237 aa)
CLCF1Cardiotrophin-like cytokine factor 1 isoform X1. (281 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
IGF2Insulin-like growth factor II isoform X3. (237 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
MZB1Marginal zone B- and B1-cell-specific protein. (188 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X6. (483 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (380 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
NDFIP1NEDD4 family-interacting protein 1. (221 aa)
VSIRV-type immunoglobulin domain-containing suppressor of T-cell activation. (311 aa)
DLG5Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (1980 aa)
TSPAN32Tetraspanin-32 isoform X1; Belongs to the tetraspanin (TM4SF) family. (571 aa)
BLKTyrosine-protein kinase. (501 aa)
IL10Interleukin-10. (178 aa)
RASSF5Ras association domain-containing protein 5 isoform X1. (422 aa)
LRRC32Leucine-rich repeat-containing protein 32 isoform X1. (676 aa)
DLG2Disks large homolog 2 isoform X1. (994 aa)
CD6T-cell differentiation antigen CD6 isoform X1. (675 aa)
CCDC88BCoiled-coil domain-containing protein 88B isoform X1. (1463 aa)
MAPK8IP1C-Jun-amino-terminal kinase-interacting protein 1 isoform X1. (718 aa)
CBLBE3 ubiquitin-protein ligase CBL-B. (983 aa)
ADAAdenosine deaminase isoform X1. (416 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
SH3RF1E3 ubiquitin-protein ligase SH3RF1 isoform X1. (872 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
TNFRSF9Tumor necrosis factor receptor superfamily member 9. (260 aa)
TNFRSF13CTumor necrosis factor receptor superfamily member 13C isoform X1. (221 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
LGALS9Galectin. (356 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
ATAD5ATPase family AAA domain-containing protein 5 isoform X1. (1898 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (454 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
HHLA2HERV-H LTR-associating protein 2 isoform X1. (414 aa)
NCK2Cytoplasmic protein. (376 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
TMEM131LTransmembrane protein 131-like isoform X1. (1608 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (180 aa)
ObLeptin isoform X1. (167 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
AHRAryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...] (845 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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