STRINGSTRING
HBEGF HBEGF BTC BTC IL15 IL15 RICTOR RICTOR PTPN11 PTPN11 IGF1 IGF1 PTPN1 PTPN1 FBXW7 FBXW7 CASS4 CASS4 EPGN EPGN EREG EREG MTOR MTOR TNFRSF18 TNFRSF18 IL21 IL21 AREG AREG VTN VTN DVL2 DVL2 IL6ST IL6ST LRRK1 LRRK1 IL31RA IL31RA HES5 HES5 PTK2B PTK2B GRM5 GRM5 UNC119 UNC119 EGFR EGFR PDGFB PDGFB MLST8 MLST8 LRP4 LRP4 NOX4 NOX4 ADRA1A ADRA1A SRC SRC CSF1R CSF1R THBS4 THBS4 EFNA5 EFNA5 ANGPT4 ANGPT4 PECAM1 PECAM1 IGF2 IGF2 CLCF1 CLCF1 IL5 IL5 EPO EPO LOC111182135 LOC111182135 CNTF CNTF CD74 CD74 FGF7 FGF7 CD81 CD81 CSF2 CSF2 LOC111182630 LOC111182630 LIF LIF AGT AGT OSM OSM HGF HGF RELN RELN FYN FYN DOK7 DOK7 NOD2 NOD2 ISL1 ISL1 FGF10 FGF10 ARL2BP ARL2BP FGFR3 FGFR3 PRNP PRNP DGKQ DGKQ SRCIN1 SRCIN1 CSF3 CSF3 LOC111166071 LOC111166071 LYN LYN FBXW9 FBXW9 ENPP2 ENPP2 ARHGEF2 ARHGEF2 HAX1 HAX1 SEMA4D SEMA4D CRLF1 CRLF1 TGFA TGFA ALKAL1 ALKAL1 PTPRC PTPRC WNT3A WNT3A KIT KIT IL6R IL6R EFNA1 EFNA1 HPX HPX ERCC6 ERCC6 GATA1 GATA1 HCLS1 HCLS1 CD40 CD40 CD80 CD80 TNFSF18 TNFSF18 SYK SYK SH2D1B SH2D1B IL12B IL12B ALKAL2 ALKAL2 PARP9 PARP9 GFRA1 GFRA1 NEURL1 NEURL1 ERBB4 ERBB4 PAK2 PAK2 AFAP1L2 AFAP1L2 ADRA2A ADRA2A ERBB3 ERBB3 HES1 HES1 EPHA4 EPHA4 NRG1 NRG1 FGF8 FGF8 IFNG IFNG PLPP3 PLPP3 HTR2A HTR2A PIBF1 PIBF1 IL12A IL12A TAL1 TAL1 ABI1 ABI1 GAS6 GAS6 LRP8 LRP8 VEGFA VEGFA NRP1 NRP1 TNFRSF1A TNFRSF1A ABL1 ABL1 PLCG2 PLCG2 BANK1 BANK1 IL34 IL34 CSPG4 CSPG4 TREM2 TREM2 BMP6 BMP6 CD44 CD44 LTK LTK NEDD9 NEDD9 IL11 IL11 GREM1 GREM1 NCF1 NCF1 ITGB3 ITGB3 LOC111182131 LOC111182131
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
BTCProbetacellulin. (178 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (180 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (623 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (451 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (707 aa)
CASS4Cas scaffolding protein family member 4 isoform X1. (821 aa)
EPGNEpigen. (153 aa)
EREGProepiregulin. (163 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
TNFRSF18LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 18. (231 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
AREGAmphiregulin isoform X1. (254 aa)
VTNVitronectin. (565 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (736 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1. (2015 aa)
IL31RALOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha. (520 aa)
HES5Transcription factor HES-5 isoform X1. (205 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
GRM5Metabotropic glutamate receptor 5 isoform X1. (1208 aa)
UNC119Protein unc-119 homolog A. (242 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X1. (326 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1905 aa)
NOX4NADPH oxidase 4. (530 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (466 aa)
SRCTyrosine-protein kinase. (562 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
THBS4Thrombospondin-4. (961 aa)
EFNA5ephrin-A5 isoform X1; Belongs to the ephrin family. (228 aa)
ANGPT4Angiopoietin-4. (498 aa)
PECAM1Platelet endothelial cell adhesion molecule isoform X1. (701 aa)
IGF2Insulin-like growth factor II isoform X3. (237 aa)
CLCF1Cardiotrophin-like cytokine factor 1 isoform X1. (281 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (193 aa)
LOC111182135Cardiotrophin-2. (202 aa)
CNTFCiliary neurotrophic factor. (200 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CD81Tetraspanin. (236 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
LOC111182630Platelet endothelial cell adhesion molecule-like isoform X2. (305 aa)
LIFLeukemia inhibitory factor. (202 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
OSMoncostatin-M. (246 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
RELNReelin isoform X1. (3460 aa)
FYNTyrosine-protein kinase. (537 aa)
DOK7Protein Dok-7 isoform X4. (356 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ARL2BPADP-ribosylation factor-like protein 2-binding protein isoform X1. (163 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
DGKQDiacylglycerol kinase. (976 aa)
SRCIN1SRC kinase signaling inhibitor 1 isoform X1. (1578 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
LOC111166071Phospholipid phosphatase 3-like. (264 aa)
LYNTyrosine-protein kinase. (518 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (461 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1. (955 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (1032 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (276 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (863 aa)
CRLF1Cytokine receptor-like factor 1. (446 aa)
TGFAProtransforming growth factor alpha isoform X1. (176 aa)
ALKAL1ALK and LTK ligand 1. (121 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
IL6RInterleukin-6 receptor subunit alpha isoform X1. (465 aa)
EFNA1ephrin-A1 isoform X3; Belongs to the ephrin family. (211 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (455 aa)
ERCC6DNA excision repair protein ERCC-6. (1485 aa)
GATA1Erythroid transcription factor isoform X1. (426 aa)
HCLS1Hematopoietic lineage cell-specific protein. (481 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X1. (284 aa)
CD80T-lymphocyte activation antigen CD80 isoform X1. (295 aa)
TNFSF18Tumor necrosis factor ligand superfamily member 18. (178 aa)
SYKTyrosine-protein kinase. (626 aa)
SH2D1BSH2 domain-containing protein 1B isoform X1. (138 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
ALKAL2ALK and LTK ligand 2 isoform X1. (152 aa)
PARP9Poly [ADP-ribose] polymerase 9 isoform X1. (847 aa)
GFRA1GDNF family receptor alpha; Belongs to the GDNFR family. (468 aa)
NEURL1E3 ubiquitin-protein ligase NEURL1 isoform X1. (574 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
AFAP1L2Actin filament-associated protein 1-like 2 isoform X1. (938 aa)
ADRA2Aalpha-2A adrenergic receptor. (465 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
HES1Transcription factor HES-1. (280 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (986 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X1. (852 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
PIBF1Progesterone-induced-blocking factor 1 isoform X1. (757 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
TAL1T-cell acute lymphocytic leukemia protein 1 isoform X1. (328 aa)
ABI1Abl interactor 1 isoform X1. (508 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
LRP8Low-density lipoprotein receptor-related protein 8 isoform X1. (996 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
BANK1B-cell scaffold protein with ankyrin repeats isoform X1. (785 aa)
IL34Interleukin-34. (235 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2315 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
CD44CD44 antigen isoform X1. (742 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (922 aa)
NEDD9Enhancer of filamentation 1 isoform X1. (829 aa)
IL11Interleukin-11. (199 aa)
GREM1Gremlin. (184 aa)
NCF1Neutrophil cytosol factor 1 isoform X2. (405 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
LOC111182131Cardiotrophin-1-like isoform X1. (264 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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