STRINGSTRING
LOC111165853 LOC111165853 TNF TNF Ob Ob H6PD H6PD SNAI1 SNAI1 SEC14L5 SEC14L5 SF1 SF1 PROX1 PROX1 INSIG2 INSIG2 PDE8B PDE8B FGF1 FGF1 STARD4 STARD4 SIRT1 SIRT1 LEP LEP EGR1 EGR1 DDX20 DDX20 BMP6 BMP6 NFKB1 NFKB1 DKKL1 DKKL1 MALRD1 MALRD1 ATP1A1 ATP1A1 BMP5 BMP5 INSIG1 INSIG1 SCAP SCAP LPCAT3 LPCAT3 IFNG IFNG STAR STAR PODN PODN APOB APOB LHCGR LHCGR DHH DHH CLCN2 CLCN2 LOC111173503 LOC111173503 ERLIN1 ERLIN1 FGFR4 FGFR4 LOC111169240 LOC111169240 NR0B1 NR0B1 SREBF1 SREBF1 LOC111169295 LOC111169295 IGFBP7 IGFBP7 CGA CGA ABCG4 ABCG4 SNAI2 SNAI2 BMP2 BMP2 NR1D1 NR1D1 DGKQ DGKQ DKK3 DKK3 GFI1 GFI1 LOC111162655 LOC111162655 LOC111162830 LOC111162830 LOC111162829 LOC111162829
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111165853Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (501 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
ObLeptin isoform X1. (167 aa)
H6PDGDH/6PGL endoplasmic bifunctional protein isoform X1. (822 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
SEC14L5SEC14-like protein 5. (694 aa)
SF1Splicing factor 1 isoform X1. (667 aa)
PROX1Prospero homeobox protein 1 isoform X1. (738 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (229 aa)
PDE8BPhosphodiesterase. (885 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
STARD4stAR-related lipid transfer protein 4 isoform X1. (241 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (735 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
DDX20Probable ATP-dependent RNA helicase DDX20. (824 aa)
BMP6Bone morphogenetic protein 6. (496 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
DKKL1Dickkopf-like protein 1. (235 aa)
MALRD1MAM and LDL-receptor class A domain-containing protein 1. (2150 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
BMP5Bone morphogenetic protein 5 isoform X1. (454 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (294 aa)
SCAPSterol regulatory element-binding protein cleavage-activating protein isoform X1. (1280 aa)
LPCAT3Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (487 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
PODNPodocan. (607 aa)
APOBApolipoprotein B-100. (4566 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
CLCN2Chloride channel protein 2 isoform X1. (908 aa)
LOC111173503Erlin-2 isoform X1. (368 aa)
ERLIN1Erlin-1 isoform X1. (369 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
LOC111169240RE1-silencing transcription factor-like isoform X2. (976 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (464 aa)
SREBF1Sterol regulatory element-binding protein 1 isoform X1. (1213 aa)
LOC111169295RE1-silencing transcription factor-like isoform X1. (981 aa)
IGFBP7Insulin-like growth factor-binding protein 7. (282 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
ABCG4ATP-binding cassette sub-family G member 4 isoform X1. (646 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
DGKQDiacylglycerol kinase. (976 aa)
DKK3Dickkopf-related protein 3. (349 aa)
GFI1Zinc finger protein Gfi-1 isoform X1. (420 aa)
LOC111162655LOW QUALITY PROTEIN: SEC14-like protein 3. (445 aa)
LOC111162830SEC14-like protein 2 isoform X1. (372 aa)
LOC111162829SEC14-like protein 2 isoform X1. (403 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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