106 items (Delphinapterus leucas) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TP53BP1	TP53-binding protein 1 isoform X1. (1976 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	SLAMF8	SLAM family member 8 isoform X1. (318 aa)
	FOXP3	Forkhead box protein P3. (431 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5 isoform X1. (284 aa)
	SYK	Tyrosine-protein kinase. (626 aa)
	TNFRSF13B	Tumor necrosis factor receptor superfamily member 13B isoform X1. (284 aa)
	IL2RG	Cytokine receptor common subunit gamma isoform X1. (381 aa)
	CARD11	Caspase recruitment domain-containing protein 11 isoform X1. (1154 aa)
	BST1	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1. (320 aa)
	HMCES	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (350 aa)
	RC3H1	Roquin-1 isoform X1. (1135 aa)
	LOC111169335	Uncharacterized protein C20orf196 homolog. (46 aa)
	SH3KBP1	SH3 domain-containing kinase-binding protein 1 isoform X1. (628 aa)
	CD28	T-cell-specific surface glycoprotein CD28. (265 aa)
	BCL6	B-cell lymphoma 6 protein. (706 aa)
	PPP2R3C	Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa)
	CTLA4	Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
	SFRP1	Secreted frizzled-related protein 1. (308 aa)
	TFRC	Transferrin receptor protein 1 isoform X1. (772 aa)
	INPP5D	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1150 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	CD38	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1. (307 aa)
	NCKAP1L	Nck-associated protein 1-like isoform X1. (1156 aa)
	RIF1	Telomere-associated protein RIF1 isoform X1. (2467 aa)
	PARP3	Poly [ADP-ribose] polymerase. (586 aa)
	TLR9	LOW QUALITY PROTEIN: toll-like receptor 9. (1323 aa)
	ZFP36L1	mRNA decay activator protein ZFP36L1. (338 aa)
	IRS2	Insulin receptor substrate 2. (1347 aa)
	LOC111176429	G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	CD27	CD27 antigen isoform X1. (251 aa)
	PCID2	PCI domain-containing protein 2 isoform X2. (399 aa)
	SAMSN1	SAM domain-containing protein SAMSN-1. (373 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	ZFP36L2	mRNA decay activator protein ZFP36L2. (493 aa)
	PAXIP1	PAX-interacting protein 1 isoform X1. (1030 aa)
	BMI1	Polycomb complex protein BMI-1. (326 aa)
	TNFSF13B	Tumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (283 aa)
	MORN5	MORN repeat-containing protein 5 isoform X1. (172 aa)
	BTK	Tyrosine-protein kinase. (687 aa)
	HMCN2	Hemicentin-2 isoform X2. (5072 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (164 aa)
	BANK1	B-cell scaffold protein with ankyrin repeats isoform X1. (785 aa)
	VAV3	Guanine nucleotide exchange factor VAV3. (954 aa)
	CD22	B-cell receptor CD22. (843 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	TNFRSF21	Tumor necrosis factor receptor superfamily member 21 isoform X3. (701 aa)
	KMT5C	Histone-lysine N-methyltransferase KMT5C isoform X1. (455 aa)
	THOC1	THO complex subunit 1. (657 aa)
	EXOSC6	Exosome complex component MTR3. (272 aa)
	BCL2	Apoptosis regulator Bcl-2. (233 aa)
	CD19	B-lymphocyte antigen CD19 isoform X1. (570 aa)
	FAM35A	Protein FAM35A isoform X1. (905 aa)
	FOXJ1	Forkhead box protein J1. (422 aa)
	SIGLEC10	Sialic acid-binding Ig-like lectin 10 isoform X1. (706 aa)
	TYROBP	TYRO protein tyrosine kinase-binding protein isoform X1. (126 aa)
	LOC111182867	CMRF35-like molecule 8 isoform X1. (313 aa)
	CD81	Tetraspanin. (236 aa)
	CD74	HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
	CLCF1	Cardiotrophin-like cytokine factor 1 isoform X1. (281 aa)
	KMT5B	Histone-lysine N-methyltransferase KMT5B isoform X1. (883 aa)
	TBC1D10C	Carabin isoform X1. (458 aa)
	MZB1	Marginal zone B- and B1-cell-specific protein. (188 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform X6. (483 aa)
	NDFIP1	NEDD4 family-interacting protein 1. (221 aa)
	BLK	Tyrosine-protein kinase. (501 aa)
	IL10	Interleukin-10. (178 aa)
	BAD	Bcl2-associated agonist of cell death. (168 aa)
	ADA	Adenosine deaminase isoform X1. (416 aa)
	SUPT6H	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
	NFAM1	NFAT activation molecule 1. (264 aa)
	LOC111186997	Solute carrier family 15 member 4-like. (90 aa)
	TNFRSF13C	Tumor necrosis factor receptor superfamily member 13C isoform X1. (221 aa)
	TNFSF13	Tumor necrosis factor ligand superfamily member 13 isoform X1; Belongs to the tumor necrosis factor family. (247 aa)
	ATAD5	ATPase family AAA domain-containing protein 5 isoform X1. (1898 aa)
	MAD2L2	Mitotic spindle assembly checkpoint protein MAD2B. (211 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
	LOC111186993	LOW QUALITY PROTEIN: solute carrier family 15 member 4-like. (615 aa)
	EXOSC3	Exosome complex component RRP40. (275 aa)
	AHR	Aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...] (845 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
	SASH3	SAM and SH3 domain-containing protein 3. (380 aa)
	CUNH20orf196	Uncharacterized protein C20orf196 homolog isoform X1. (225 aa)
	PAWR	PRKC apoptosis WT1 regulator protein. (345 aa)
	LYN	Tyrosine-protein kinase. (518 aa)
	IL7	Interleukin-7 isoform X1. (226 aa)
	IL27RA	Interleukin-27 receptor subunit alpha isoform X1. (656 aa)
	LOC111166997	Fc receptor-like protein 3 isoform X2. (726 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (785 aa)
	PKN1	Serine/threonine-protein kinase N1 isoform X1. (950 aa)
	LOC111166483	Signal transducer and activator of transcription. (787 aa)
	STAT5A	Signal transducer and activator of transcription. (818 aa)
	MMP14	Matrix metalloproteinase-14. (582 aa)
	TBX21	T-box transcription factor TBX21. (535 aa)
	IKZF3	Zinc finger protein Aiolos isoform X1. (509 aa)
	CD320	CD320 antigen. (265 aa)
	NSD2	Histone-lysine N-methyltransferase NSD2 isoform X1. (1375 aa)
	THEMIS2	Protein THEMIS2 isoform X1. (648 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
	XBP1	LOW QUALITY PROTEIN: X-box-binding protein 1. (392 aa)
	EPHB2	Ephrin type-B receptor 2 isoform X1. (987 aa)
	AKIRIN2	Akirin-2. (203 aa)

Your Current Organism:

Delphinapterus leucas

NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	ATM	A0A2Y9Q7U1	A0A2Y9M6F8	ATPase family AAA domain-containing protein 5 isoform X1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.559
ATAD5	MAD2L2	A0A2Y9Q7U1	A0A2Y9Q938	ATPase family AAA domain-containing protein 5 isoform X1.	Mitotic spindle assembly checkpoint protein MAD2B.	0.587
ATAD5	PAXIP1	A0A2Y9Q7U1	A0A2Y9NM26	ATPase family AAA domain-containing protein 5 isoform X1.	PAX-interacting protein 1 isoform X1.	0.407
ATM	ATAD5	A0A2Y9M6F8	A0A2Y9Q7U1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATPase family AAA domain-containing protein 5 isoform X1.	0.559
ATM	BCL2	A0A2Y9M6F8	A0A2Y9P9P5	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Apoptosis regulator Bcl-2.	0.535
ATM	BMI1	A0A2Y9M6F8	A0A2Y9NM47	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Polycomb complex protein BMI-1.	0.442
ATM	CDKN1A	A0A2Y9M6F8	A0A2Y9NTU9	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase inhibitor 1.	0.438
ATM	MSH2	A0A2Y9M6F8	A0A2Y9NJZ7	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.596
ATM	NSD2	A0A2Y9M6F8	A0A2Y9LU27	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone-lysine N-methyltransferase NSD2 isoform X1.	0.610
ATM	PAXIP1	A0A2Y9M6F8	A0A2Y9NM26	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PAX-interacting protein 1 isoform X1.	0.934
ATM	RIF1	A0A2Y9M6F8	A0A2Y9N1Z8	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Telomere-associated protein RIF1 isoform X1.	0.820
ATM	TP53BP1	A0A2Y9M6F8	A0A2Y9PCI2	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TP53-binding protein 1 isoform X1.	0.955
BAD	BCL2	A0A2Y9PW98	A0A2Y9P9P5	Bcl2-associated agonist of cell death.	Apoptosis regulator Bcl-2.	0.998
BANK1	BTK	A0A2Y9NYV9	A0A2Y9NR66	B-cell scaffold protein with ankyrin repeats isoform X1.	Tyrosine-protein kinase.	0.430
BANK1	CD22	A0A2Y9NYV9	A0A2Y9P4I8	B-cell scaffold protein with ankyrin repeats isoform X1.	B-cell receptor CD22.	0.411
BANK1	LYN	A0A2Y9NYV9	A0A2Y9LZZ2	B-cell scaffold protein with ankyrin repeats isoform X1.	Tyrosine-protein kinase.	0.533
BCL2	ATM	A0A2Y9P9P5	A0A2Y9M6F8	Apoptosis regulator Bcl-2.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.535
BCL2	BAD	A0A2Y9P9P5	A0A2Y9PW98	Apoptosis regulator Bcl-2.	Bcl2-associated agonist of cell death.	0.998
BCL2	BCL6	A0A2Y9P9P5	A0A2Y9MT32	Apoptosis regulator Bcl-2.	B-cell lymphoma 6 protein.	0.614
BCL2	BMI1	A0A2Y9P9P5	A0A2Y9NM47	Apoptosis regulator Bcl-2.	Polycomb complex protein BMI-1.	0.514