STRINGSTRING
CD80 CD80 IGLL1 IGLL1 CCL19 CCL19 SOCS1 SOCS1 XBP1 XBP1 FAM49B FAM49B CD40LG CD40LG FOXO3 FOXO3 NOD2 NOD2 VNN1 VNN1 MYB MYB TNFSF14 TNFSF14 TYK2 TYK2 RARA RARA STAT5A STAT5A LOC111166483 LOC111166483 CCR7 CCR7 DHPS DHPS FCHO1 FCHO1 IL27RA IL27RA IL12RB1 IL12RB1 RASAL3 RASAL3 IL7 IL7 TMIGD2 TMIGD2 IL18 IL18 SASH3 SASH3 ZBTB16 ZBTB16 PTPRC PTPRC TNFSF9 TNFSF9 ZBTB7B ZBTB7B SLAMF1 SLAMF1 SPTA1 SPTA1 EGR3 EGR3 FOXP3 FOXP3 THY1 THY1 SYK SYK IL2RG IL2RG LOC111167809 LOC111167809 IL12B IL12B LOC111169054 LOC111169054 AIF1 AIF1 CARD11 CARD11 AGER AGER CD86 CD86 LEF1 LEF1 ICOS ICOS TNFSF4 TNFSF4 CD28 CD28 GPAM GPAM IHH IHH BCL6 BCL6 DPP4 DPP4 HSPD1 HSPD1 RHOH RHOH IGFBP2 IGFBP2 TFRC TFRC ZBTB1 ZBTB1 NCKAP1L NCKAP1L HES1 HES1 ANXA1 ANXA1 ADAM8 ADAM8 SOCS5 SOCS5 TNFSF11 TNFSF11 SLC7A1 SLC7A1 CD274 CD274 WNT10B WNT10B RHOA RHOA LOC111175407 LOC111175407 PDCD1LG2 PDCD1LG2 IFNG IFNG SHH SHH CD27 CD27 IL12A IL12A DOCK8 DOCK8 ITPKB ITPKB BMI1 BMI1 TNFSF13B TNFSF13B LCK LCK HLX HLX LOC111178664 LOC111178664 LOC111178928 LOC111178928 LOC111178931 LOC111178931 PRKCQ PRKCQ LOC111178668 LOC111178668 NCK1 NCK1 LOC111178925 LOC111178925 LOC111178929 LOC111178929 LOC111176900 LOC111176900 ABL1 ABL1 EPHB6 EPHB6 DUSP10 DUSP10 CAV1 CAV1 IL12RB2 IL12RB2 GATA3 GATA3 LOC111178666 LOC111178666 BCL10 BCL10 BTNL2 BTNL2 TGFB1 TGFB1 IL4I1 IL4I1 LOC111178927 LOC111178927 PPP3CA PPP3CA CD83 CD83 MALT1 MALT1 TRAF6 TRAF6 PYCARD PYCARD PTPN22 PTPN22 RASGRP1 RASGRP1 ZP3 ZP3 LEP LEP CD81 CD81 KAT5 KAT5 CD74 CD74 AMBRA1 AMBRA1 CORO1A CORO1A IGF2 IGF2 FADD FADD LOC111184361 LOC111184361 SART1 SART1 RPS3 RPS3 VSIR VSIR ZMIZ1 ZMIZ1 CD6 CD6 CCDC88B CCDC88B BAD BAD CD5 CD5 EFNB3 EFNB3 ADA ADA AP3B1 AP3B1 SIRPA SIRPA SOX12 SOX12 GLI3 GLI3 SOX13 SOX13 NFKBIZ NFKBIZ TNFRSF13C TNFRSF13C IL6ST IL6ST LOC111187417 LOC111187417 FLOT2 FLOT2 IL7R IL7R PIK3R6 PIK3R6 IL21 IL21 PRKCZ PRKCZ HHLA2 HHLA2 LOC111187428 LOC111187428 NCK2 NCK2 PCK1 PCK1 IGF1 IGF1 IL1RL2 IL1RL2 IL15 IL15 SHB SHB Ob Ob IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD80T-lymphocyte activation antigen CD80 isoform X1. (295 aa)
IGLL1Immunoglobulin lambda-like polypeptide 1 isoform X1. (212 aa)
CCL19C-C motif chemokine. (159 aa)
SOCS1Suppressor of cytokine signaling 1. (215 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (392 aa)
FAM49BProtein FAM49B isoform X1. (324 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
FOXO3Forkhead box protein O3. (672 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
VNN1Pantetheinase. (514 aa)
MYBTranscriptional activator Myb isoform X3. (761 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14 isoform X1. (241 aa)
TYK2Tyrosine-protein kinase. (1188 aa)
RARARetinoic acid receptor alpha isoform X5. (584 aa)
STAT5ASignal transducer and activator of transcription. (818 aa)
LOC111166483Signal transducer and activator of transcription. (787 aa)
CCR7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
DHPSDeoxyhypusine synthase. (369 aa)
FCHO1F-BAR domain only protein 1. (887 aa)
IL27RAInterleukin-27 receptor subunit alpha isoform X1. (656 aa)
IL12RB1Interleukin-12 receptor subunit beta-1 isoform X1. (726 aa)
RASAL3RAS protein activator like-3 isoform X1. (1035 aa)
IL7Interleukin-7 isoform X1. (226 aa)
TMIGD2Transmembrane and immunoglobulin domain-containing protein 2. (231 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (673 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1258 aa)
TNFSF9Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (252 aa)
ZBTB7BZinc finger and BTB domain-containing protein 7B. (541 aa)
SLAMF1Signaling lymphocytic activation molecule isoform X1. (378 aa)
SPTA1Spectrin alpha chain, erythrocytic 1 isoform X1. (2417 aa)
EGR3Early growth response protein 3 isoform X1. (387 aa)
FOXP3Forkhead box protein P3. (431 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
SYKTyrosine-protein kinase. (626 aa)
IL2RGCytokine receptor common subunit gamma isoform X1. (381 aa)
LOC111167809ephrin-B1 isoform X1; Belongs to the ephrin family. (346 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
LOC111169054NF-kappa-B-activating protein. (417 aa)
AIF1Allograft inflammatory factor 1 isoform X1. (162 aa)
CARD11Caspase recruitment domain-containing protein 11 isoform X1. (1154 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (344 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
ICOSInducible T-cell costimulator isoform X1. (227 aa)
TNFSF4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (182 aa)
CD28T-cell-specific surface glycoprotein CD28. (265 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (877 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
DPP4Dipeptidyl peptidase 4 isoform X1; Belongs to the peptidase S9B family. (804 aa)
HSPD160 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (573 aa)
RHOHRho-related GTP-binding protein RhoH. (191 aa)
IGFBP2Insulin-like growth factor-binding protein 2 isoform X1. (320 aa)
TFRCTransferrin receptor protein 1 isoform X1. (772 aa)
ZBTB1Zinc finger and BTB domain-containing protein 1. (713 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1156 aa)
HES1Transcription factor HES-1. (280 aa)
ANXA1Annexin. (346 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8 isoform X1. (838 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
SLC7A1High affinity cationic amino acid transporter 1. (629 aa)
CD274Programmed cell death 1 ligand 1 isoform X2. (312 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
RHOATransforming protein RhoA. (193 aa)
LOC111175407Amine oxidase. (524 aa)
PDCD1LG2Programmed cell death 1 ligand 2 isoform X1. (337 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
CD27CD27 antigen isoform X1. (251 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
DOCK8Dedicator of cytokinesis protein 8 isoform X1; Belongs to the DOCK family. (2098 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (941 aa)
BMI1Polycomb complex protein BMI-1. (326 aa)
TNFSF13BTumor necrosis factor ligand superfamily member 13B; Belongs to the tumor necrosis factor family. (283 aa)
LCKTyrosine-protein kinase. (509 aa)
HLXH2.0-like homeobox protein. (488 aa)
LOC111178664HLA class II histocompatibility antigen, DM beta chain isoform X1. (263 aa)
LOC111178928DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
LOC111178931HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
PRKCQProtein kinase C. (665 aa)
LOC111178668HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
NCK1Cytoplasmic protein. (377 aa)
LOC111178925boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X2. (276 aa)
LOC111178929HLA class II histocompatibility antigen, DRB1-4 beta chain-like isoform X1. (231 aa)
LOC111176900GTPase IMAP family member 5-like isoform X1. (332 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
EPHB6Ephrin type-B receptor 6 isoform X1. (1010 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
IL12RB2Interleukin-12 receptor subunit beta-2 isoform X1. (861 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
LOC111178666HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (261 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
BTNL2Butyrophilin-like protein 2. (454 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
IL4I1L-amino-acid oxidase isoform X1. (653 aa)
LOC111178927HLA class II histocompatibility antigen, DQ alpha 2 chain; Belongs to the MHC class II family. (255 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CD83CD83 antigen isoform X1. (195 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (850 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (561 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD. (195 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (801 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (870 aa)
ZP3Zona pellucida sperm-binding protein 3. (421 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
CD81Tetraspanin. (236 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
AMBRA1Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1295 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
IGF2Insulin-like growth factor II isoform X3. (237 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
LOC111184361Signal-regulatory protein beta-1-like isoform X1. (412 aa)
SART1U4/U6.U5 tri-snRNP-associated protein 1. (803 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
VSIRV-type immunoglobulin domain-containing suppressor of T-cell activation. (311 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1 isoform X1. (1071 aa)
CD6T-cell differentiation antigen CD6 isoform X1. (675 aa)
CCDC88BCoiled-coil domain-containing protein 88B isoform X1. (1463 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CD5T-cell surface glycoprotein CD5 isoform X1. (500 aa)
EFNB3ephrin-B3 isoform X1; Belongs to the ephrin family. (340 aa)
ADAAdenosine deaminase isoform X1. (416 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1087 aa)
SIRPATyrosine-protein phosphatase non-receptor type substrate 1 isoform X1. (504 aa)
SOX12Transcription factor SOX. (312 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1587 aa)
SOX13Transcription factor SOX-13. (644 aa)
NFKBIZNF-kappa-B inhibitor zeta. (726 aa)
TNFRSF13CTumor necrosis factor receptor superfamily member 13C isoform X1. (221 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
LOC111187417Tyrosine-protein kinase. (612 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
IL7RInterleukin-7 receptor subunit alpha isoform X1. (459 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6 isoform X1. (881 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa)
HHLA2HERV-H LTR-associating protein 2 isoform X1. (414 aa)
LOC111187428Interleukin-1. (118 aa)
NCK2Cytoplasmic protein. (376 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1. (687 aa)
IGF1Insulin-like growth factor I isoform X1. (186 aa)
IL1RL2Interleukin-1 receptor-like 2 isoform X1. (570 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (180 aa)
SHBSH2 domain-containing adapter protein B. (507 aa)
ObLeptin isoform X1. (167 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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