STRINGSTRING
SELPLG SELPLG EXT1 EXT1 PODXL2 PODXL2 SELP SELP SELE SELE CX3CR1 CX3CR1 SELL SELL ADD2 ADD2 ITGA4 ITGA4 MADCAM1 MADCAM1 ITGB7 ITGB7 JAM2 JAM2 GCNT1 GCNT1 ROCK1 ROCK1 GOLPH3 GOLPH3 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SELPLGP-selectin glycoprotein ligand 1. (450 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (746 aa)
PODXL2Podocalyxin-like protein 2 isoform X1. (607 aa)
SELPP-selectin isoform X1. (768 aa)
SELEE-selectin. (531 aa)
CX3CR1CX3C chemokine receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (372 aa)
ADD2Beta-adducin isoform X1. (836 aa)
ITGA4Integrin alpha-4 isoform X1; Belongs to the integrin alpha chain family. (1033 aa)
MADCAM1Mucosal addressin cell adhesion molecule 1. (406 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (819 aa)
JAM2Junctional adhesion molecule B isoform X1. (350 aa)
GCNT1beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase isoform X1. (485 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.