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AIF1 AIF1 TMEM102 TMEM102 AGER AGER SLIT2 SLIT2 BST1 BST1 BMPR2 BMPR2 SEMA3D SEMA3D SEMA3E SEMA3E LOC111168870 LOC111168870 MSTN MSTN LOC111171403 LOC111171403 PRSS56 PRSS56 SEMA4G SEMA4G KDR KDR CXCL12 CXCL12 MPP1 MPP1 TNFAIP6 TNFAIP6 PLXNA3 PLXNA3 LOC111172293 LOC111172293 LOC111171267 LOC111171267 DPP4 DPP4 STK39 STK39 GPSM3 GPSM3 VEGFC VEGFC NCKAP1L NCKAP1L SEMA5B SEMA5B CXCR4 CXCR4 SEMA3F SEMA3F MST1 MST1 CCR1 CCR1 SCG2 SCG2 WNT5A WNT5A ADGRA2 ADGRA2 FGFR1 FGFR1 HABP2 HABP2 TBR1 TBR1 EDN2 EDN2 FEZF2 FEZF2 SEMA3B SEMA3B ANGPT2 ANGPT2 LOC111176429 LOC111176429 PGF PGF MYCBP2 MYCBP2 DNM1L DNM1L ANO6 ANO6 SEMA3G SEMA3G CCR2 CCR2 IL12A IL12A RARRES2 RARRES2 LGMN LGMN PTN PTN CAMK1D CAMK1D GAS6 GAS6 EFNB2 EFNB2 GPR18 GPR18 C5 C5 SEMA7A SEMA7A AKIRIN1 AKIRIN1 C3AR1 C3AR1 DEF6 DEF6 ADAM10 ADAM10 FGF16 FGF16 RIN3 RIN3 PLA2G7 PLA2G7 SWAP70 SWAP70 CCR7 CCR7 OXSR1 OXSR1 S100A14 S100A14 LYN LYN XCL1 XCL1 JAM3 JAM3 SEMA4D SEMA4D CXCR3 CXCR3 CCR6 CCR6 RIPOR2 RIPOR2 SEMA4A SEMA4A SLAMF1 SLAMF1 SEMA4F SEMA4F TRPV4 TRPV4 CREB3 CREB3 POU4F2 POU4F2 CXCL13 CXCL13 PADI2 PADI2 CMKLR1 CMKLR1 CXCL10 CXCL10 P2RX4 P2RX4 SEMA4C SEMA4C FGF18 FGF18 DUSP1 DUSP1 PTK2B PTK2B C1QBP C1QBP LOC111185731 LOC111185731 PDGFB PDGFB RAC2 RAC2 DEFB124 DEFB124 LBP LBP VEGFB VEGFB MCU MCU CSF1R CSF1R THBS4 THBS4 FGF1 FGF1 STX3 STX3 FGF4 FGF4 SEMA6A SEMA6A CD74 CD74 THBS1 THBS1 TPBG TPBG CORO1B CORO1B ATOH7 ATOH7 CXCL14 CXCL14 TUBB2A TUBB2A WNT3 WNT3 HSPB1 HSPB1 LOC111181895 LOC111181895 ZNF580 ZNF580 MAPK3 MAPK3 SEMA6D SEMA6D CCL26 CCL26 CSF1 CSF1 NEDD9 NEDD9 LOC111181312 LOC111181312 LOC111181277 LOC111181277 TGFB1 TGFB1 RYK RYK C5AR2 C5AR2 C5AR1 C5AR1 PLXNA4 PLXNA4 TNFSF14 TNFSF14 TREM2 TREM2 MEGF8 MEGF8 PRKD2 PRKD2 SEMA5A SEMA5A IL34 IL34 ROBO1 ROBO1 MET MET NOTCH1 NOTCH1 CDH13 CDH13 SUCNR1 SUCNR1 WNK1 WNK1 F7 F7 LOC111168867 LOC111168867 MOSPD2 MOSPD2 CALR CALR NTRK3 NTRK3 WNT3A WNT3A SEMA4B SEMA4B PDGFRA PDGFRA CX3CR1 CX3CR1 SEMA6C SEMA6C SMOC2 SMOC2 LOC111168869 LOC111168869 VEGFD VEGFD CCL19 CCL19 F2RL1 F2RL1 MAPK1 MAPK1 CCL21 CCL21 LOC111163731 LOC111163731 PRKD1 PRKD1 MMP28 MMP28 PPM1F PPM1F FAM49B FAM49B PTPN2 PTPN2 CCL27 CCL27 IL16 IL16 CCL5 CCL5 NOD2 NOD2 FGF10 FGF10 NOV NOV SEMA3C SEMA3C DSCAM DSCAM SEMA6B SEMA6B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AIF1Allograft inflammatory factor 1 isoform X1. (162 aa)
TMEM102LOW QUALITY PROTEIN: transmembrane protein 102. (506 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (631 aa)
SLIT2Slit homolog 2 protein isoform X1. (1534 aa)
BST1ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 isoform X1. (320 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SEMA3Dsemaphorin-3D isoform X1; Belongs to the semaphorin family. (777 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (775 aa)
LOC111168870semaphorin-3A-like; Belongs to the semaphorin family. (249 aa)
MSTNGrowth/differentiation factor 8. (375 aa)
LOC111171403LOW QUALITY PROTEIN: transmembrane protein 102-like. (288 aa)
PRSS56LOW QUALITY PROTEIN: serine protease 56; Belongs to the peptidase S1 family. (606 aa)
SEMA4Gsemaphorin-4G isoform X1; Belongs to the semaphorin family. (843 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
CXCL12Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
MPP155 kDa erythrocyte membrane protein; Belongs to the MAGUK family. (466 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein isoform X1. (284 aa)
PLXNA3plexin-A3. (1872 aa)
LOC111172293Hyaluronan-binding protein 2. (553 aa)
LOC111171267Ubiquitin carboxyl-terminal hydrolase 14-like. (97 aa)
DPP4Dipeptidyl peptidase 4 isoform X1; Belongs to the peptidase S9B family. (804 aa)
STK39STE20/SPS1-related proline-alanine-rich protein kinase isoform X1. (539 aa)
GPSM3G-protein-signaling modulator 3. (162 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
NCKAP1LNck-associated protein 1-like isoform X1. (1156 aa)
SEMA5Bsemaphorin-5B isoform X1. (1093 aa)
CXCR4C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (785 aa)
MST1Hepatocyte growth factor-like protein isoform X1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
CCR1C-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
SCG2Secretogranin-2. (615 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (458 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1337 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
HABP2Hyaluronan-binding protein 2. (433 aa)
TBR1T-box brain protein 1. (681 aa)
EDN2Endothelin-2. (147 aa)
FEZF2Fez family zinc finger protein 2. (458 aa)
SEMA3Bsemaphorin-3B isoform X1; Belongs to the semaphorin family. (748 aa)
ANGPT2Angiopoietin-2 isoform X1. (496 aa)
LOC111176429G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (360 aa)
PGFPlacenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (170 aa)
MYCBP2E3 ubiquitin-protein ligase MYCBP2 isoform X1. (4763 aa)
DNM1LDynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (763 aa)
ANO6Anoctamin. (951 aa)
SEMA3Gsemaphorin-3G isoform X1; Belongs to the semaphorin family. (773 aa)
CCR2C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
RARRES2Retinoic acid receptor responder protein 2. (166 aa)
LGMNLegumain. (433 aa)
PTNPleiotrophin isoform X1. (168 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D isoform X1. (435 aa)
GAS6Growth arrest-specific protein 6. (671 aa)
EFNB2ephrin-B2; Belongs to the ephrin family. (333 aa)
GPR18N-arachidonyl glycine receptor; Belongs to the G-protein coupled receptor 1 family. (338 aa)
C5Complement C5 isoform X1. (1677 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (665 aa)
AKIRIN1Akirin-1 isoform X1. (206 aa)
C3AR1C3a anaphylatoxin chemotactic receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (498 aa)
DEF6Differentially expressed in FDCP 6 homolog isoform X1. (673 aa)
ADAM10Disintegrin and metalloproteinase domain-containing protein 10. (748 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
RIN3Ras and Rab interactor 3 isoform X1. (1010 aa)
PLA2G7Platelet-activating factor acetylhydrolase. (443 aa)
SWAP70Switch-associated protein 70. (585 aa)
CCR7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
OXSR1Serine/threonine-protein kinase OSR1. (523 aa)
S100A14Protein S100-A14; Belongs to the S-100 family. (104 aa)
LYNTyrosine-protein kinase. (518 aa)
XCL1Lymphotactin. (111 aa)
JAM3Junctional adhesion molecule C. (301 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (863 aa)
CXCR3C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (366 aa)
CCR6C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
RIPOR2Rho family-interacting cell polarization regulator 2 isoform X2. (1048 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (762 aa)
SLAMF1Signaling lymphocytic activation molecule isoform X1. (378 aa)
SEMA4Fsemaphorin-4F isoform X1; Belongs to the semaphorin family. (789 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (870 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (370 aa)
POU4F2POU domain protein. (407 aa)
CXCL13C-X-C motif chemokine 13. (109 aa)
PADI2Protein-arginine deiminase type-2. (665 aa)
CMKLR1Chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (365 aa)
CXCL10C-X-C motif chemokine. (103 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
SEMA4Csemaphorin-4C isoform X1; Belongs to the semaphorin family. (945 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1015 aa)
C1QBPComplement component 1 Q subcomponent-binding protein, mitochondrial. (278 aa)
LOC111185731C-C motif chemokine. (99 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (278 aa)
RAC2Ras-related C3 botulinum toxin substrate 2 isoform X2. (192 aa)
DEFB124Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (70 aa)
LBPLipopolysaccharide-binding protein isoform X1. (537 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (209 aa)
MCUCalcium uniporter protein, mitochondrial isoform X1. (371 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
THBS4Thrombospondin-4. (961 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
STX3Syntaxin-3 isoform X1; Belongs to the syntaxin family. (289 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1044 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
THBS1Thrombospondin-1. (1170 aa)
TPBGTrophoblast glycoprotein. (419 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (640 aa)
ATOH7Protein atonal homolog 7. (152 aa)
CXCL14C-X-C motif chemokine 14. (99 aa)
TUBB2ATubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
HSPB1Heat shock protein beta-1; Belongs to the small heat shock protein (HSP20) family. (201 aa)
LOC111181895Oncomodulin; Belongs to the parvalbumin family. (132 aa)
ZNF580Zinc finger protein 580 isoform X1. (182 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SEMA6Dsemaphorin-6D isoform X1; Belongs to the semaphorin family. (1073 aa)
CCL26C-C motif chemokine 26. (94 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
NEDD9Enhancer of filamentation 1 isoform X1. (829 aa)
LOC111181312Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
LOC111181277Tubulin beta-4B chain-like. (85 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
RYKTyrosine-protein kinase RYK isoform X1. (609 aa)
C5AR2C5a anaphylatoxin chemotactic receptor 2 isoform X1. (343 aa)
C5AR1C5a anaphylatoxin chemotactic receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (424 aa)
PLXNA4plexin-A4 isoform X1. (1981 aa)
TNFSF14Tumor necrosis factor ligand superfamily member 14 isoform X1. (241 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (294 aa)
MEGF8LOW QUALITY PROTEIN: multiple epidermal growth factor-like domains protein 8. (2784 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
SEMA5Asemaphorin-5A isoform X1. (1079 aa)
IL34Interleukin-34. (235 aa)
ROBO1Roundabout homolog 1 isoform X1. (1685 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
NOTCH1Neurogenic locus notch homolog protein 1 isoform X1. (2521 aa)
CDH13Cadherin-13 isoform X1. (713 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (318 aa)
WNK1Serine/threonine-protein kinase WNK1 isoform X1. (2825 aa)
F7Coagulation factor VII isoform X1. (447 aa)
LOC111168867semaphorin-3A isoform X1. (306 aa)
MOSPD2Motile sperm domain-containing protein 2 isoform X1. (518 aa)
CALRCalreticulin. (417 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SEMA4Bsemaphorin-4B; Belongs to the semaphorin family. (822 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CX3CR1CX3C chemokine receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (475 aa)
SEMA6Csemaphorin-6C isoform X5; Belongs to the semaphorin family. (966 aa)
SMOC2SPARC-related modular calcium-binding protein 2 isoform X1. (456 aa)
LOC111168869semaphorin-3A-like; Belongs to the semaphorin family. (273 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
CCL19C-C motif chemokine. (159 aa)
F2RL1Proteinase-activated receptor 2. (315 aa)
MAPK1Mitogen-activated protein kinase. (380 aa)
CCL21C-C motif chemokine 21 isoform X1. (131 aa)
LOC111163731C-C motif chemokine. (93 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (910 aa)
MMP28Matrix metalloproteinase-28 isoform X1. (520 aa)
PPM1FProtein phosphatase 1F. (433 aa)
FAM49BProtein FAM49B isoform X1. (324 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2 isoform X3. (474 aa)
CCL27LOW QUALITY PROTEIN: C-C motif chemokine 27. (117 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1326 aa)
CCL5C-C motif chemokine. (91 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1086 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
NOVProtein NOV homolog. (359 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
DSCAMDown syndrome cell adhesion molecule isoform X2. (1577 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (880 aa)
Your Current Organism:
Delphinapterus leucas
NCBI taxonomy Id: 9749
Other names: D. leucas, beluga, beluga whale, white whale
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